CXCL12 is expressed by skeletal muscle cells in tongue oral squamous cell carcinoma
Cancer Medicine, 2023 Background The CXCL12/CXCR4 axis plays a pivotal role in the progression of various malignancies, including oral squamous cell carcinoma (OSCC).
Akira Yorozu +19 more
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CXCL14 antagonizes the CXCL12-CXCR4 signaling axis
Biomolecular Concepts, 2014 CXCL12 and CXCL14 are evolutionarily conserved members of the CXC-type chemokine family. CXCL12 binds specifically to the G-protein-coupled receptor CXCR4 to induce the migration of primordial germ cells, hematopoietic stem cells, and inflammation ...
Hara Takahiko, Tanegashima Kosuke
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Frontiers in Bioengineering and Biotechnology, 2022 Cancer-associated fibroblasts (CAFs) play an active role in remodeling the local tumor stroma to support tumor initiation, growth, invasion, metastasis, and therapeutic resistance.
Jacob C. Holter +12 more
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CXCL12 and [N33A]CXCL12 in 5637 and HeLa cells: regulating HER1 phosphorylation via calmodulin/calcineurin. [PDF]
PLoS ONE, 2012 In the human neoplastic cell lines 5637 and HeLa, recombinant CXCL12 elicited, as expected, downstream signals via both G-protein-dependent and β-arrestin-dependent pathways responsible for inducing a rapid and a late wave, respectively, of ERK1/2 ...
Antonella Rigo +6 more
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Tzu Chi Medical JournalChemokines are small, secreted cytokines crucial in the regulation of a variety of cell functions. The binding of chemokine C-X-C motif chemokine ligand 12 (CXCL12) (stromal cell-derived factor 1) to a G-protein-coupled receptor C-X-C chemokine receptor ...
Jui-Hung Yen +5 more
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Combined detection of CXCR7 and CXCL12 for diagnosing acute myocardial infarction and predicting post-percutaneous coronary intervention major adverse cardiovascular events [PDF]
Journal of Medical BiochemistryBackground: To explore the diagnostic utility of combined CXCR7 and CXCL12 testing in acute myocardial infarction (AMI) and its predictive value for post-percutaneous coronary intervention (PCI) major adverse cardiovascular events (MACE).
Pan Hong +4 more
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M1 macrophage-derived CXCL12 drives neurogenic heterotopic ossification following spinal cord injury
Neural Regeneration ResearchPatients with spinal cord injury frequently develop neurogenic heterotopic ossification, whose pathogenesis remains incompletely understood. Existing research models struggle to accurately simulate the complex pathological process.
Yulei Xie +5 more
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Significance of CXCL12/CXCR4 Ligand/Receptor Axis in Various Aspects of Acute Myeloid Leukemia
Cancer Management and Research, 2020 Zinat Yazdani,1 Zahra Mousavi,2 Alireza Moradabadi,1 Gholamhossein Hassanshahi1,3 1Department of Hematology and Blood Banking, Kerman University of Medical Sciences, Kerman, Iran; 2Department of Hematology and Medical Laboratory Sciences, Iranshahr ...
Yazdani Z +3 more
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CXCL12 Promotes Stem Cell Recruitment and Uterine Repair after Injury in Asherman’s Syndrome
Molecular Therapy: Methods & Clinical Development, 2017 Asherman’s syndrome is an acquired condition of uterine fibrosis and adhesions in response to injury that adversely affects fertility and pregnancy. We have previously demonstrated that bone marrow-derived mesenchymal stem cells (BMDSCs) contribute to ...
Gulcin Sahin Ersoy +5 more
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CIRP Regulates BEV-Induced Cell Migration in Gliomas [Corrigendum]
Cancer Management and Research, 2020 Liu Y, Zhou JN, Liu K, et al. Cancer Manag Res. 2019;11:2015–2025. The authors have advised there are errors in Figures 2 and 4 on pages 2019 and 2021, respectively. Figure 2B, mistakes were made in the labelling of the ...
Liu Y +6 more
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