Results 51 to 60 of about 54,272 (286)

CXCL12 promotes endometrial repair through MSC homing in a mouse model of intrauterine adhesions: Multimechanistic study based on angiogenesis, cell proliferation and Sirt1 upregulation

陆军军医大学学报
Objective To investigate CXCL12 therapeutic potential in endometrial repair post intrauterine adhesion (IUA) surgery. Methods A murine model of IUA was established using mechanical curettage.
SHAO Kangning, WANG Yaqin
doaj   +1 more source

Association of CXCL12 and CXCR4 Genes Polymorphism with Proliferative Diabetic Retinopathy in Diabetic Patients

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2022
Introduction: Patients with diabetes are prone to develop complications related to the retina. So far, several genes have been reported in connection with the progression of retinopathy, and a group of these genes is genes involved in angiogenesis ...
Saba Gharibi, Shiva Aghaei, Ensieh Shahvazian, Mohammad Bagher Mahmoodi, Mohammad Hossein Sahami-Fard, Parisa kolahdouz, Ehsan Farashahi Yazd   +6 more
doaj  

The clinical usefulness of chemokine C-X-C Motif Ligand 12 as a diagnostic marker for Papillary Thyroid Carcinoma

Indian Journal of Pathology and Microbiology, 2020
Background: Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer worldwide. It is essential to develop methods for the accurate diagnosis of PTC to avoid unnecessary surgery.
Sang Ah Lee, Jae Hyuck Choi, Suk Ju Cho, Jee Won Chang, Young Hee Maeng   +4 more
doaj   +1 more source

Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration [PDF]

, 2009
FLT3-ITD-mediated leukemogenesis is associated with increased expression of oncogenic PIM serine/threonine kinases. To dissect their role in FLT3-ITD-mediated transformation, we performed bone marrow reconstitution assays.
Spoo, A, Bullock, AN, Spoo, Anke Cornelia, Duyster, Justus, Pogacic, Vanda, Dechow, Tobias, Andrea Biondi, Grundler, R, Sabine Ehret, Spoo, Anke, Vanda Pogacic, Anke Spoo, Bullock, Alex N., Villa, A, Pogacic, V, Ehret, S, Georgina Berridge, Knapp, S, Dechow, T, Berridge, G, Tobias Dechow, Juerg Schwaller, Christine Dierks, Grundler, Rebekka, Schwaller, J, Duyster, J, Laurent Brault, Bullock, Alexander, Woetzel, S, Antonello Villa, Dierks, Christine, Brault, Laurent, Stefan Knapp, Justus Duyster, Villa, Antonello, Gasser, C, Gasser, Christelle, Rebekka Grundler, Biondi, A, Sabine Woetzel, Brault, L, Woetzel, Sabine, Knapp, Stefan, Schwaller, Juerg, Biondi, Andrea, Dierks, C, Alex N. Bullock, Christelle Gasser, Ehret, Sabine, Wötzel, Sabine, Berridge, Georgina   +50 more
core   +1 more source

Advances in CXCR7 Modulators

Pharmaceuticals, 2020
CXC chemokine receptor 7 (CXCR7) is a G-protein-coupled receptor that signals through the β-arrestin pathway. Its ligands include interferon-inducible T cell α chemoattractant (CXCL11) and stromal cell-derived factor-1 (CXCL12).
Nicole Lounsbury
doaj   +1 more source

Effects of cognate, non-cognate and synthetic CXCR4 and ACKR3 ligands on human lung endothelial cell barrier function. [PDF]

PLoS ONE, 2017
Recent evidence suggests that chemokine CXCL12, the cognate agonist of chemokine receptors CXCR4 and ACKR3, reduces thrombin-mediated impairment of endothelial barrier function.
You-Hong Cheng, Jonathan M Eby, Heather M LaPorte, Brian F Volkman, Matthias Majetschak   +4 more
doaj   +1 more source

CXCL12-inudced ERK1/2 phosphorylation in HEK293 cells is augmented after transfection with CXCR4 and ACKR3.

, 2018
HEK293 cells were transfected with empty vector (left), CXCR4 (center) or ACKR3 (right) and stimulated with 100 nM of CXCL12 for various time periods as indicated.
Hazem Abdelkarim (1883086), Vadim Gaponenko (1883077), Lauren J. Albee (5782589), Matthias Majetschak (2848619), Xianlong Gao (3746263), Brian F. Volkman (502457)   +5 more
core   +1 more source

CXCL12 Signaling Is Independent of Jak2 and Jak3 [PDF]

Journal of Biological Chemistry, 2005
Janus kinases (Jaks) are a small family of cytoplasmic tyrosine kinases, critical for signaling by Type I and II cytokine receptors. The importance of Jaks in signaling by these receptors has been firmly established by analysis of mutant cell lines, the generation of Jak knock-out mice, and the identification of patients with Jak3 mutations.
Masato, Moriguchi, Bruce D, Hissong, Massimo, Gadina, Kunihiro, Yamaoka, H Lee, Tiffany, Philip M, Murphy, Fabio, Candotti, John J, O'Shea   +7 more
openaire   +3 more sources

NLRP3 Regulated CXCL12 Expression in Acute Neutrophilic Lung Injury

Journal of Inflammation Research, 2020
Yanwen Peng,1 Qiongli Wu,2 Hao Tang,3 Jingrou Chen,1 Qili Wu,1 Xiaofeng Yuan,4 Shiqiu Xiong,5 Yujin Ye,6 Haijin Lv7 1The Biotherapy Center, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, People’s Republic of China ...
Peng Y, Wu Q, Tang H, Chen J, Wu Q, Yuan X, Xiong S, Ye Y, Lv H   +8 more
doaj  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source