Results 41 to 50 of about 44,475 (230)
Pharmaceuticals, 2020 CXC chemokine receptor 7 (CXCR7) is a G-protein-coupled receptor that signals through the β-arrestin pathway. Its ligands include interferon-inducible T cell α chemoattractant (CXCL11) and stromal cell-derived factor-1 (CXCL12).
Nicole Lounsbury
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Effects of cognate, non-cognate and synthetic CXCR4 and ACKR3 ligands on human lung endothelial cell barrier function. [PDF]
PLoS ONE, 2017 Recent evidence suggests that chemokine CXCL12, the cognate agonist of chemokine receptors CXCR4 and ACKR3, reduces thrombin-mediated impairment of endothelial barrier function.
You-Hong Cheng +4 more
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CXCL12 Signaling Is Independent of Jak2 and Jak3 [PDF]
Journal of Biological Chemistry, 2005 Janus kinases (Jaks) are a small family of cytoplasmic tyrosine kinases, critical for signaling by Type I and II cytokine receptors. The importance of Jaks in signaling by these receptors has been firmly established by analysis of mutant cell lines, the generation of Jak knock-out mice, and the identification of patients with Jak3 mutations.
Masato, Moriguchi +7 more
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CXCL12 Signaling in the Development of the Nervous System [PDF]
Journal of Neuroimmune Pharmacology, 2012 Chemokines are small, secreted proteins that have been shown to be important regulators of leukocyte trafficking and inflammation. All the known effects of chemokines are transduced by action at a family of G protein coupled receptors. Two of these receptors, CCR5 and CXCR4, are also known to be the major cellular receptors for HIV-1.
Divakar S, Mithal +2 more
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NLRP3 Regulated CXCL12 Expression in Acute Neutrophilic Lung Injury
Journal of Inflammation Research, 2020 Yanwen Peng,1 Qiongli Wu,2 Hao Tang,3 Jingrou Chen,1 Qili Wu,1 Xiaofeng Yuan,4 Shiqiu Xiong,5 Yujin Ye,6 Haijin Lv7 1The Biotherapy Center, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, People’s Republic of China ...
Peng Y +8 more
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Frontiers in Immunology, 2018 CXCL12 is a chemotactic cytokine that attracts many different cell types for homeostasis and during inflammation. Under stress conditions, macrophages and granulocytes produce factors such as peroxynitrite as a consequence of their oxidative response ...
Rik Janssens +19 more
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陆军军医大学学报Objective To investigate CXCL12 therapeutic potential in endometrial repair post intrauterine adhesion (IUA) surgery. Methods A murine model of IUA was established using mechanical curettage.
SHAO Kangning, WANG Yaqin
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The CXCL12/CXCR7 signaling axis, isoforms, circadian rhythms, and tumor cellular composition dictate gradients in tissue. [PDF]
PLoS ONE, 2017 Chemokine CXCL12 gradients drive chemotaxis in a CXCR4-dependent mechanism and have been implicated in cancer metastasis. While CXCL12 gradients are typically studied in organized, defined environments, the tumor microenvironment is disorganized. In vivo,
Phillip C Spinosa +3 more
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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
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Clinical and Experimental Hypertension, 2017 Objective: We investigated whether the CXCL12-801G/A polymorphism was associated with preeclampsia (PE) susceptibility in a Chinese Han population. Methods: We examined 912 PE women and 1025 controls for the CXCL12-801G/A polymorphism by polymerase chain
Jine Xu +6 more
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