Results 21 to 30 of about 44,475 (230)

Fragment-Based Optimization of Small Molecule CXCL12 Inhibitors for Antagonizing the CXCL12/CXCR4 Interaction [PDF]

Current Topics in Medicinal Chemistry, 2013
The chemokine CXCL12 and its G protein-coupled receptor (GPCR) CXCR4 are high-priority clinical targets because of their involvement in metastatic cancers (also implicated in autoimmune disease and cardiovascular disease). Because chemokines interact with two distinct sites to bind and activate their receptors, both the GPCRs and chemokines are ...
Joshua J, Ziarek, Yan, Liu, Emmanuel, Smith, Guolin, Zhang, Francis C, Peterson, Jun, Chen, Yongping, Yu, Yu, Chen, Brian F, Volkman, Rongshi, Li   +9 more
openaire   +2 more sources

CXCL12 and CXCR4 as Potential Early Biomarkers for Luminal A and Luminal B Subtypes of Breast Cancer

Cancer Management and Research, 2023
Joanna Motyka,1 Ewa Gacuta,2 Aleksandra Kicman,3 Monika Kulesza,1 Paweł Malinowski,4 Sławomir Ławicki1 1Department of Population Medicine and Lifestyle Diseases Prevention, Medical University of Bialystok, Bialystok, Poland ...
Motyka J, Gacuta E, Kicman A, Kulesza M, Malinowski P, Ławicki S   +5 more
doaj  

MiR-886-3p down regulates CXCL12 (SDF1) expression in human marrow stromal cells. [PDF]

PLoS ONE, 2010
Stromal Derived Factor 1 (SDF1 or CXCL12), is a chemokine known to be critical for the migration of cells in several tissue systems including the homing of the hematopoietic stem cell (HSC) to its niche in the bone marrow. A comparative analysis of miRNA
Manoj M Pillai, Xiaodong Yang, Ilango Balakrishnan, Lynne Bemis, Beverly Torok-Storb   +4 more
doaj   +1 more source

Inhibition of nitric oxide synthase activity and chemokine (CXCL12) supplementation can improve hematopoietic reconstitution in mice lethally irradiated by 60Co gamma radiation

Brazilian Journal of Radiation Sciences, 2019
Reduction of nitric oxide (NO) production is related to increased survival in some models of infection and ionizing radiation (IR) exposure. The work used lethally irradiated (60Co, 8Gy) C57Bl6j mice, treated or not with aminoguanidine (AG), an inhibitor
Daniel Perez Vieira, Andrés Jimenez Galisteo Jr., Heitor Franco de Andrade Jr.   +2 more
doaj   +1 more source

Enrichment of Cxcl12 promoter with TET2: A possible link between promoter demethylation and enhanced gene expression in the absence of PARP-1 [PDF]

Archives of Biological Sciences, 2019
Previously, we described the link between C-X-C motif chemokine 12 (Cxcl12) gene induction and DNA hypomethylation in the absence of poly(ADP-ribose) polymerase 1 (PARP-1).
Tolić Anja Z., Rajić Jovana J., Đorđević Marija B., Đorđević Miloš M., Dinić Svetlana S., Grdović Nevena M., Arambašić-Jovanović Jelena D., Mihailović Mirjana V., Poznanović Goran Đ., Jurkowski Tomasz P., Vidaković Melita S., Uskoković Aleksandra S.   +11 more
doaj   +1 more source

T-ALL: Home Is where the CXCL12 Is [PDF]

Cancer Cell, 2015
T cell acute lymphoblastic leukemia (T-ALL) is caused by mutations affecting cell survival, proliferation, and differentiation. In addition to requiring these mutations, Passaro and colleagues and Pitt and colleagues in this issue of Cancer Cell demonstrate that T-ALL initiating cells residing in bone marrow depend on the CXCR4/CXCL12 signaling axis ...
de Bock, Charles E., Cools, Jan
openaire   +2 more sources

The CXCL12 Crossroads in Cancer Stem Cells and Their Niche [PDF]

Cancers, 2021
Cancer stem cells (CSCs) are defined as a subpopulation of “stem”-like cells within the tumor with unique characteristics that allow them to maintain tumor growth, escape standard anti-tumor therapies and drive subsequent repopulation of the tumor. This is the result of their intrinsic “stem”-like features and the strong driving influence of the CSC ...
Juan Carlos López-Gil, Laura Martin-Hijano, Patrick C. Hermann, Bruno Sainz   +3 more
openaire   +5 more sources

mTORC2 mediates CXCL12-induced angiogenesis [PDF]

Angiogenesis, 2016
The chemokine CXCL12, through its receptor CXCR4, positively regulates angiogenesis by promoting endothelial cell (EC) migration and tube formation. However, the relevant downstream signaling pathways in EC have not been defined. Similarly, the upstream activators of mTORC2 signaling in EC are also poorly defined.
Ziegler, Mary E, Hatch, Michaela MS, Wu, Nan, Muawad, Steven A, Hughes, Christopher CW   +4 more
openaire   +4 more sources

STUDY OF CXCL12, CCR4, EGFR GENE EXPRESSION IN MIGRATING MYELOMONOBLASTIC LEUKEMIA CELLS BEFORE AND AFTER CHEMOTHERAPY

Журнал микробиологии, эпидемиологии и иммунобиологии, 2019
Аim. A study of CXCL12 effect on the migration of mononuclear cells isolated from healthy patients, from patients with myelomonoblastic leukemia before and after chemotherapy and the study of CCR4, EGFR and CXCL12 genes expression after exposure to ...
A. B. Filina, O. A. Svitich, Yu. I. Ammur, A. K. Golenkov, E. F. Klinushkina, V. V. Zverev   +5 more
doaj   +1 more source

Glycosaminoglycan silencing by engineered CXCL12 variants [PDF]

FEBS Letters, 2015
We have engineered GPCR (G protein‐coupled receptor) knock‐out and high GAG‐binding affinity into CXCL12α to inhibit CXCL12α‐induced cell migration. Compared to wtCXCL12, the mutant CXCL12α (Δ8 L29K V39K) exhibited a 5.6‐fold and a 2.2‐fold affinity increase for heparin and heparan sulfate, respectively.
Gschwandtner M, Trinker MU, Hecher B, Adage T, Ali S, Kungl AJ   +5 more
openaire   +3 more sources