Results 61 to 70 of about 54,272 (286)

CXCL12 Signaling in the Development of the Nervous System [PDF]

Journal of Neuroimmune Pharmacology, 2012
Chemokines are small, secreted proteins that have been shown to be important regulators of leukocyte trafficking and inflammation. All the known effects of chemokines are transduced by action at a family of G protein coupled receptors. Two of these receptors, CCR5 and CXCR4, are also known to be the major cellular receptors for HIV-1.
Divakar S, Mithal, Ghazal, Banisadr, Richard J, Miller   +2 more
openaire   +2 more sources

Synoviocyte-Derived CXCL12 Is Displayed on Endothelium and Induces Angiogenesis in Rheumatoid Arthritis

, 2003
CXCL12 (stromal cell-derived factor-1) is a potent CXC chemokine that is constitutively expressed by stromal resident cells. Although it is considered a homeostatic rather than an inflammatory chemokine, CXCL12 has been immunodetected in different ...
Brehmer, María T., Santiago, Begoña, Torres, Carmen, García Lázaro, Francisco J., Galindo Izquierdo, María, Pablos Álvarez, José Luis, Blanco, Francisco J.   +6 more
core   +1 more source

CXCL12-CXCR4 Interplay Facilitates Palatal Osteogenesis in Mice. [PDF]

, 2020
Cranial neural crest cells (CNCCs), identified by expression of transcription factor Sox9, migrate to the first branchial arch and undergo proliferation and differentiation to form the cartilage and bone structures of the orofacial region, including the ...
Suttorp, Christiaan M, van Rheden, Rene E. M., Suttorp, Christiaan M., Kuijpers-Jagtman, Anne Marie; id_orcid, Regan, Raymond F, Helmich, Maria P. A. C., Wagener, Frank A D T G, Wagener, Frank A. D. T. G., Verheijen, Nanne, Helmich, Maria P A C, Regan, Raymond F., Kuijpers-Jagtman, Anne Marie, van Rheden, René E M, Kuijpers-Jagtman, Anne-Marie   +13 more
core   +3 more sources

CXCL12 is expressed by skeletal muscle cells in tongue oral squamous cell carcinoma

Cancer Medicine, 2023
Background The CXCL12/CXCR4 axis plays a pivotal role in the progression of various malignancies, including oral squamous cell carcinoma (OSCC).
Akira Yorozu, Shohei Sekiguchi, Akira Takasawa, Fumika Okazaki, Takeshi Niinuma, Hiroshi Kitajima, Eiichiro Yamamoto, Masahiro Kai, Mutsumi Toyota, Yui Hatanaka, Koyo Nishiyama, Kazuhiro Ogi, Hironari Dehari, Kazufumi Obata, Makoto Kurose, Atsushi Kondo, Makoto Osanai, Akihiro Miyazaki, Kenichi Takano, Hiromu Suzuki   +19 more
doaj   +1 more source

An Integrative Strategy Delineates Modular Metabolic Remodeling and Potential Therapeutic Targets Across Metabolic Diseases

Advanced Science, EarlyView.
An integrative single‐cell atlas across multiple metabolic diseases reveals coordinated metabolic modules and disease‐shared versus disease‐specific pathway activities. By systematically comparing scoring strategies, a robust RankAve framework is established. Coupled with network analysis and drug‐target prediction, this resource uncovers cross‐disease
Kuan Yang, Congxue Hu, Hang Zhao, Xiao Peng, Yiming Yan, Jiasi Wang, Wenqi Jiang, Depeng Mu, Yan Cao, Xia Li, Yunpeng Zhang   +10 more
wiley   +1 more source

Matrix Stiffness Induces Endothelial Network Senescence

Advanced Science, EarlyView.
Using a 3D human in vitro model that decouples mechanical stress from inflammatory or biochemical signals, matrix stiffening induces a senescence phenotype in endothelial networks. This mechano‐induced senescence activates Notch signaling, and pharmacologic Notch inhibition attenuates this stiffness‐induced senescence.
Jiyeon Song, Alexandra N. Rindone, Ya Guan, Connor D. Amelung, Prarthana Sanjay Daswani, Jennifer H. Elisseeff, Sharon Gerecht   +6 more
wiley   +1 more source

Inhibition of CXCR4–CXCL12 chemotaxis in melanoma by AMD11070 [PDF]

British Journal of Cancer, 2013
Despite intensive research and novel adjuvant therapies, there is currently no cure for metastatic melanoma. The chemokine receptor CXCR4 controls metastasis to sites such as the liver; however, the therapeutic blockade with the existing agents has proven difficult.AMD11070, a novel orally bioavailable inhibitor of CXCR4, was tested for its ability to ...
O'Boyle, Graeme, Swidenbank, I, Marshall, H, Barker, CE, Armstrong, Jane, White, SA, Fricker, SP, Plummer, R, Wright, M, Lovat, PE   +9 more
openaire   +4 more sources

CXC receptor-4 mRNA silencing abrogates CXCL12-induced migration of colorectal cancer cells [PDF]

, 2011
Background Interactions between CXCR4 and its ligand CXCL12 have been shown to be involved in cancer progression in colorectal cancer (CRC). We performed a comparative CXCL12/CXCR4 expression analysis and assessed the effect of external CXCL12 ...
Christoph Justinger, Ghadjar, Pirus, Schilling Martin K, Ghadjar Pirus, Frick, Vilma O, Martin K Schilling, Kollmar, Otto, Justinger Christoph, Wagner, Mathias, Kollmar Otto, Pirus Ghadjar, Stefan Gräber, Wagner Mathias, Rubie, Claudia, Claudia Rubie, Faust Sabrina K, Frick Vilma O, Vilma O Frick, Rubie Claudia, Vicinus, Benjamin, Mathias Wagner, Sabrina K Faust, Otto Kollmar, Justinger, Christoph, Gräber Stefan, Faust, Sabrina K, Gräber, Stefan, Schilling, Martin K, Benjamin Vicinus, Vicinus Benjamin   +29 more
core   +2 more sources

CXCL14 antagonizes the CXCL12-CXCR4 signaling axis

Biomolecular Concepts, 2014
CXCL12 and CXCL14 are evolutionarily conserved members of the CXC-type chemokine family. CXCL12 binds specifically to the G-protein-coupled receptor CXCR4 to induce the migration of primordial germ cells, hematopoietic stem cells, and inflammation ...
Hara Takahiko, Tanegashima Kosuke
doaj   +1 more source

Fibroblast-derived CXCL12 increases vascular permeability in a 3-D microfluidic model independent of extracellular matrix contractility

Frontiers in Bioengineering and Biotechnology, 2022
Cancer-associated fibroblasts (CAFs) play an active role in remodeling the local tumor stroma to support tumor initiation, growth, invasion, metastasis, and therapeutic resistance.
Jacob C. Holter, Chia-Wen Chang, Alex Avendano, Ayush A. Garg, Ajeet K. Verma, Ajeet K. Verma, Manish Charan, Dinesh K. Ahirwar, Dinesh K. Ahirwar, Ramesh K. Ganju, Ramesh K. Ganju, Jonathan W. Song, Jonathan W. Song   +12 more
doaj   +1 more source