Results 71 to 80 of about 54,272 (286)

THBS1+ Macrophages Exacerbate Modic Changes via SDC4‐Dependent Activation of NLRP3 Inflammasome

Advanced Science, EarlyView.
The illustration of THBS1+ macrophages exacerbate MCs via SDC4‐dependent activation of the NLRP3 inflammasome. THBS1+ macrophage subpopulation was identified in MCs through single‐cell RNA sequencing. C. acnes and its metabolites activate THBS1 expression in macrophages via the TLR signaling pathway.
Xiangxi Kong, Qize Xue, Xiaoan Wei, Jie Li, Bao Huang, Weishao Chen, Zimin Cai, Tao Yang, Chengjun Yao, Jiayan Jin, Bohan Cai, Xuyang Zhang, Junhui Liu, Haihao Wu, Jian Chen, Zhi Shan, Fengdong Zhao   +16 more
wiley   +1 more source

Functional assays of the S6-tagged CXCL12.

, 2014
(A) Scintillation proximity assay of the CXCR4∶CXCL12-S6 interaction. HEK293s cells expressing CXCR4 were incubated with 125I-labeled CXCL12, and the amount of cell-bound radioactivity was measured in the presence of WT CXCL12 (green), P2G-CXCL12 (blue ...
Bryan Stephens (515767), Irina Kufareva (379208), Neil Grimsey (37852), Tracy M. Handel (245262), Michael R. Dores (515768), Tetsuya Kawamura (515766), Thomas H. Smith (515769), JoAnn Trejo (515770), Ling Qin (68169), Catherina L. Salanga (245254), Mark M. Fuster (515771), Xin Yin (149454), Ruben Abagyan (220938)   +12 more
core   +1 more source

Slc44a2 Deficiency Unveils an IFN‐I–Dependent Feedback Control of pDC Egress

Advanced Science, EarlyView.
Working model of SLC44A2‐mediated maintenance of pDC homeostasis. This model illustrates two central mechanisms by which SLC44A2 regulates pDC homeostasis: (1) SLC44A2 limits IFN‐I production by exporting amino acids (T, N, Q), thereby preventing spontaneous pDC activation.
Ruiqun Chen, Tao Wu, Zhen Shi, Ravi Kumar Verma, Linlin Sheng, Lei Tao, Mingming Yang, Yuchen Wang, Conggang Zhang, Hao Fan, Li Wu, Ligong Chen   +11 more
wiley   +1 more source

Quantitative phosphoproteomics of CXCL12 (SDF-1) signaling. [PDF]

, 2011
CXCL12 (SDF-1) is a chemokine that binds to and signals through the seven transmembrane receptor CXCR4. The CXCL12/CXCR4 signaling axis has been implicated in both cancer metastases and human immunodeficiency virus type 1 (HIV-1) infection and a more ...
Jessica Y Lee, Steven H Seeholzer, Jason A. Wojcechowskyj, Steven H. Seeholzer, Jason A Wojcechowskyj, Jessica Y. Lee, Wojcechowskyj Jason A., Doms Robert W., Lee Jessica Y., Robert W Doms, Robert W. Doms, Seeholzer Steven H.   +11 more
core   +1 more source

C-X-C motif chemokine ligand 12—C-X-C chemokine receptor type 4 signaling axis in cancer and the development of chemotherapeutic molecules

Tzu Chi Medical Journal
Chemokines are small, secreted cytokines crucial in the regulation of a variety of cell functions. The binding of chemokine C-X-C motif chemokine ligand 12 (CXCL12) (stromal cell-derived factor 1) to a G-protein-coupled receptor C-X-C chemokine receptor ...
Jui-Hung Yen, Chun-Chun Chang, Hao-Jen Hsu, Chin-Hao Yang, Hemalatha Mani, Je-Wen Liou   +5 more
doaj   +1 more source

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, EarlyView.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source

A Spatially Directed Microneedle Patch Enables Intratumoral Co‐Delivery of FOLFIRINOX, Surufatinib, and Anti‐PD‐1 for Chemo‐Immunotherapy of Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
A double‐layered shell‐core microneedle patch is developed to co‐deliver FOLFIRINOX, surufatinib, and anti‐PD‐1 for localized chemo‐immunotherapy of PDAC. This strategy achieves sustained tumor suppression, reduces metastasis, and reprograms the TME by enhancing CD8+ T‐cell infiltration and inhibiting Tregs and M2 macrophages infiltration, while ...
Tingting Kong, Ximo Xu, Xiao Zhang, Chuntao Wu, Zhengjun Qiu, Beiyuan Hu, Zihao Qi, Qiang Tian, Yuqin Yang, Hanguang Dong, Fei Wu, Tuo Jin, Yan Zheng, Jiang Long   +13 more
wiley   +1 more source

Nitric oxide inhibits CXCL12 expression in neuroinflammation

, 2013
Chemokine CXCL12 (C-X-C motif chemokine ligand 12) restricts immune cell invasion of the central nervous system (CNS) and limits neuroinflammation in experimental autoimmune encephalomyelitis (EAE), an animal model of inflammatory and demyelinating ...
Blaževski, Jana, Mostarica-Stojković, Marija B, Momčilović, Miljana, Miljković, Đorđe, Petković, Filip   +4 more
core   +5 more sources

CXCR4-CXCL12-CXCR7 and PD-1/PD-L1 in Pancreatic Cancer: CXCL12 Predicts Survival of Radically Resected Patients

, 2022
Pancreatic ductal adenocarcinoma (PDAC) is currently the most deadly cancer. Although characterized by 5–20% of neoplastic cells in the highly fibrotic stroma, immunotherapy is not a valid option in PDAC treatment.
De Vita, Ferdinando, Stefania Scala, Napolitano, Vincenzo, Scala, Stefania, Luigi Portella, D'Alterio, Crescenzo, Giardino, Alessandro, Martignoni, Guido, Tatangelo, Fabiana, Giuseppe Guardascione, Scognamiglio, Giosuè, Alessandro Giardino, Guardascione, Giuseppe, Butturini, Giovanni, Guido Martignoni, Vincenzo Napolitano, Giosuè Scognamiglio, Giovanni Butturini, Montella, Marco, Franco, Renato, Crescenzo D’Alterio, Gobbo, Stefano, Isabella Frigerio, Stefano Gobbo, D’Alterio, Crescenzo, Frigerio, Isabella, Ferdinando De Vita, Marco Montella, Fabiana Tatangelo, Portella, Luigi, Renato Franco   +30 more
core   +2 more sources

Combined detection of CXCR7 and CXCL12 for diagnosing acute myocardial infarction and predicting post-percutaneous coronary intervention major adverse cardiovascular events [PDF]

Journal of Medical Biochemistry
Background: To explore the diagnostic utility of combined CXCR7 and CXCL12 testing in acute myocardial infarction (AMI) and its predictive value for post-percutaneous coronary intervention (PCI) major adverse cardiovascular events (MACE).
Pan Hong, Fan Xiaoli, Liu Yu, Aishan Gulijiakela, Shao Jingwen   +4 more
doaj   +1 more source