Results 71 to 80 of about 44,475 (230)
Advanced Science, EarlyView.Periprosthetic joint infection establishes a sophisticated immunosuppressive network between CXCR4+ PMN‐MDSCs and Bregs, inducing profound CD8+ T cell paralysis. Alendronate effectively disrupts this CXCR4+ PMN‐MDSC–Breg axis by targeting STAT3, thereby restoring local immune surveillance.
Jintao Wu +9 more
wiley +1 more source
Osteoblast Sorting and Intracellular Staining of CXCL12
BIO-PROTOCOL, 2018 Osteoblasts are bone marrow endosteum-lining niche cells playing important roles in the regulation of hematopoietic stem cells by secreting factors and cell adhesion molecules. Characterization of primary osteoblasts has been achieved through culture of outgrowth of collagenase treated bone.
Weihuan Wang +3 more
openaire +4 more sources
CXCL12, CXCR4 and CXCR7 expression in brain metastases [PDF]
Cancer Biology & Therapy, 2009 Brain metastases occur in about 25% of patients who die of cancer. The most common sources of brain metastases in adults are lung, breast, kidney, colorectal cancer and melanoma. The chemokine/receptor system CXCL12/CXCR4 plays a key role in multiple biological functions; among these, homing of neoplastic cells from the primary site to the target and ...
Paola Gaviani +9 more
openaire +3 more sources
CIRP Regulates BEV-Induced Cell Migration in Gliomas [Corrigendum]
Cancer Management and Research, 2020 Liu Y, Zhou JN, Liu K, et al. Cancer Manag Res. 2019;11:2015–2025. The authors have advised there are errors in Figures 2 and 4 on pages 2019 and 2021, respectively. Figure 2B, mistakes were made in the labelling of the ...
Liu Y +6 more
doaj
miR-135a-5p alleviates morphine tolerance by targeting the regulation of CXCL12 expression [PDF]
Jichu yixue yu linchuangObjective Investigating the effect of miR-135a-5p in regulating of CXCL12 on the formation of morphine tolerance in C57BL/6J mice. Methods Totally 64 mice were randomly divided into the following groups: control (NS) group, morphine tolerance (MT ...
HE Huamei, LU Wei
doaj +1 more source
Cytokine Pathways Driving Diverse Tissue Pathologies in Rheumatoid Arthritis
Arthritis &Rheumatology, EarlyView.Rheumatoid arthritis (RA) is a complex systemic disorder characterized primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra‐articular disease, such as that of the lung, with potentially devastating clinical consequences. The critical importance of comorbidities,
Aurelie Najm +2 more
wiley +1 more source
Arthritis &Rheumatology, EarlyView.Objective The hematopoietic system maintains homeostasis by balancing myeloid and lymphoid cell production in the bone marrow (BM). In response to increased hematopoietic demand, extramedullary hematopoiesis (EMH) may occur in nonlymphoid organs. We investigated the role of EMH and kidney‐resident hematopoietic stem and progenitor cells (HSPCs) in ...
Hansol Yi +9 more
wiley +1 more source
Multiple functions of CXCL12 in a syngeneic model of breast cancer
Molecular Cancer, 2010 Background A growing body of work implicates chemokines, in particular CXCL12 and its receptors, in the progression and site-specific metastasis of various cancers, including breast cancer.
Smyth Mark J +5 more
doaj +1 more source
Human Fibroblast–Myeloid Cell Tissue Atlas Across the Lungs, Synovium, Skin, and Heart
Arthritis &Rheumatology, EarlyView.Objective The availability of single‐cell RNA sequencing (scRNAseq) data in different tissues and disease states provides an opportunity to compare cellular subsets and identify common and unique cellular activation. In this study, we aimed to characterize shared and tissue‐specific myeloid and stromal phenotypes and to uncover key cellular subtypes ...
Lucy MacDonald +9 more
wiley +1 more source
Platelet Indices and CXCL12 Levels in Patients with Intrauterine Growth Restriction
International Journal of Women's Health, 2020 Shole Shahgheibi,1,* Roya Mardani,1,* Erfan Babaei,2 Parastoo Mardani,3 Masomeh Rezaie,1 Fariba Farhadifar,1 Daem Roshani,2 Mobin Naqshbandi,2 Ali Jalili2 1Deparment of Obstetrics and Gynecology, Faculty of Medicine, Kurdistan University of Medical ...
Shahgheibi S +8 more
doaj