Results 1 to 10 of about 64,182 (259)

A new variant of lumpy skin disease virus circulating in Vietnam based on sequencing analysis of GPCR gene

Open Veterinary Journal
Background: In 2021, Vietnam experienced an outbreak of Lumpy skin disease (LSD), which infected 207,687 cattle and buffaloes, as officially reported, and resulted in the culling of 29,182 animals.
Ha Thi Thanh Tran, Anh Duc Truong, Anh Tuan Tran, Nhu Thi Chu, Vinh The Nguyen, Hoang Vu Dang   +5 more
doaj   +1 more source

The Application of Artificial Intelligence Accelerates G Protein-Coupled Receptor Ligand Discovery

Engineering
G protein-coupled receptors (GPCRs) are crucial players in various physiological processes, making them attractive candidates for drug discovery. However, traditional approaches to GPCR ligand discovery are time-consuming and resource-intensive.
Wei Chen, Chi Song, Liang Leng, Sanyin Zhang, Shilin Chen   +4 more
doaj   +1 more source

G-protein-coupled receptor diversity and evolution in the closest living relatives of metazoa

eLife
G-protein-coupled receptors (GPCRs) play a pivotal role in the perception of environmental cues across eukaryotic diversity. Although GPCRs have been relatively well characterized in metazoans, GPCR signaling is poorly understood in their sister group ...
Alain Garcia De Las Bayonas, Nicole King
doaj   +1 more source

toGC: A pipeline to correct gene model for functional excavation of dark GPCRs in Phytophthora sojae

Journal of Integrative Agriculture
The accuracy of genomic annotation is crucial for subsequent functional investigations; however, computational protocols used in high-throughput annotation of open reading frames (ORFs) can introduce inconsistencies.
Min Qiu, Chun Yan, Huaibo Li, Haiyang Zhao, Siqun Tu, Yaru Sun, Saijiang Yong, Ming Wang, Yuanchao Wang   +8 more
doaj   +1 more source

P-Rex1 limits the agonist-induced internalization of GPCRs independently of its Rac-GEF activity

Cell Reports
Summary: The guanine-nucleotide exchange factor (GEF) P-Rex1 mediates G protein-coupled receptor (GPCR) signaling by activating the small GTPase Rac. We show here that P-Rex1 also controls GPCR trafficking.
Martin J. Baker, Elizabeth Hampson, Priota Islam, Ruben Pelaez Moral, Eve A. Maunders, Kirsti Hornigold, Elpida Tsonou, Angeliki Malliri, David C. Hornigold, Roderick E. Hubbard, Andrew J. Massey, Heidi C.E. Welch   +11 more
doaj   +1 more source

Genome-wide pan-GPCR cell libraries accelerate drug discovery

Acta Pharmaceutica Sinica B
G protein-coupled receptors (GPCRs) are pivotal in mediating diverse physiological and pathological processes, rendering them promising targets for drug discovery.
Hanting Yang, Yongfu Wang, Wei Liu, Taiping He, Jiayu Liao, Zhongzhi Qian, Jinghao Zhao, Zhaotong Cong, Dan Sun, Zhixiang Liu, Can Wang, Lingping Zhu, Shilin Chen   +12 more
doaj   +1 more source

Structure and Function of GPCR Dimer

Shengwu huaxue yu shengwu wuli jinzhan
G-protein coupled receptors (GPCRs) are an essential family of proteins on the cell membrane, widely distributed in various types of tissues and cells. Typical GPCRs are composed of characteristic 7 transmembrane α-helix domains, extracellular domain ...
LI Chuan-Bao, LI Chen-Hui, XUE Li
doaj   +1 more source

Sub 3Å cryoEM structure using a standard LaB6 120kV TEM upgraded with direct electron detector [PDF]

BIO Web of Conferences
Venugopal Hari, Mobbs Jesse, Taveneau Cyntia, Fox Daniel, Knott Gavin, Grinter Rhys, Thal David, Ramm Georg   +7 more
doaj   +1 more source

Editorial: GPCR and G Protein-Mediated Signalling Events in the Nervous System

Frontiers in Cellular Neuroscience, 2022
Yamina A. Berchiche, Terence E. Hébert
doaj   +1 more source

G Protein-Coupled Receptor in High-Altitude Diseases: Mechanistic Insights and Therapeutic Opportunities. [PDF]

MedComm (2020)
Zhao Q, Liu C, Dai L, Zheng K, Liang K, Pan C, Liu L, Chen L, He X, Yan H, Chen L, Zheng H, Deng C, Luo F.   +13 more
europepmc   +1 more source