Nile Red-Based GPCR Ligands as Ultrasensitive Probes of the Local Lipid Microenvironment of the Receptor [PDF]
, 2020 The local lipid microenvironment of transmembrane receptors is an essential factor in GPCR signaling. However, tools are currently missing for studying endogenously expressed GPCRs in primary cells and tissues.
Iuliia, Karpenko +6 more
core +2 more sources
Frontiers in Endocrinology, 2013 A G protein-coupled receptor (GPCR) functions not only as a monomer or homodimer but also as a heterodimer with another GPCR. GPCR heterodimerization results in the modulation of the molecular functions of the GPCR protomer, including ligand binding ...
Honoo Satake +2 more
exaly +3 more sources
ACE2 interaction with cytoplasmic PDZ protein enhances SARS-CoV-2 invasion
iScience, 2021 Summary: SARS-CoV-2 is responsible for the global COVID-19 pandemic. Angiotensin converting enzyme 2 (ACE2) is the membrane-delimited receptor for SARS-CoV-2.
Qiangmin Zhang +4 more
doaj +1 more source
Bioinformatics Analysis of the Melanocortin 1 Receptor Gene (MC1R) in the Southern Platyfish Xiphophorus maculatus (Günther, 1866) [PDF]
International Journal Bioautomation, 2020 The Southern platyfish Xiphophorus maculatus is one of the most popular ornamental fish used widely as a premier model system in understanding the genetic basis of color pattern polymorphism. Coloration in X.
Abdul Khader Sultan Mohideen, Anbu Arun
doaj +1 more source
Alterations in Dendritic Spine Maturation and Neurite Development Mediated by FAM19A1
Cells, 2021 Neurogenesis and functional brain activity require complex associations of inherently programmed secretory elements that are regulated precisely and temporally.
Hyo-Jeong Yong +2 more
doaj +1 more source
Advances in GPCR modeling evaluated by the GPCR Dock 2013 assessment: meeting new challenges. [PDF]
, 2014 Despite tremendous successes of GPCR crystallography, the receptors with available structures represent only a small fraction of human GPCRs. An important role of the modeling community is to maximize structural insights for the remaining receptors and ...
Kufareva I +5 more
core +3 more sources
LPA1-mediated inhibition of CXCR4 attenuates CXCL12-induced signaling and cell migration
Cell Communication and Signaling, 2023 Background G protein-coupled receptor heteromerization is believed to exert dynamic regulatory impact on signal transduction. CXC chemokine receptor 4 (CXCR4) and its ligand CXCL12, both of which are overexpressed in many cancers, play a pivotal role in ...
Jong Min Hong +4 more
doaj +1 more source
Scientific Reports, 2023 C-X-C chemokine receptor 4 (CXCR4) is widely overexpressed in various types of cancer and is involved in several cancer phenotypes including tumor growth, survival, and metastasis.
Chulo Park +5 more
doaj +1 more source
Heparin-bound chemokine CXCL8 monomer and dimer are impaired for CXCR1 and CXCR2 activation: implications for gradients and neutrophil trafficking [PDF]
Open Biology, 2017 Chemokine CXCL8 plays a pivotal role in host immune response by recruiting neutrophils to the infection site. CXCL8 exists as monomers and dimers, and mediates recruitment by interacting with glycosaminoglycans (GAGs) and activating CXCR1 and CXCR2 ...
Prem Raj B. Joseph +2 more
doaj +1 more source
Patriarchi/GPCR-based_GEFIs_Applications: GPCR-based_GEFIs_Applications
, 2023 Repository of studies using GPCR-based GEFIs from May 2018 until Sep ...
Patriarchi Lab
core +1 more source