Results 31 to 40 of about 83,092 (356)
GPCR Inhibition in Treating Lymphoma [PDF]
, 2022 G protein-coupled receptors (GPCRs) are important classes of cell surface receptors involved in multiple physiological functions. Aberrant expression, upregulation, and mutation of GPCR signaling pathways are frequent in many types of cancers, promoting ...
Raimondi M. V. +8 more
core +1 more source
Arrestin-3 differentially regulates platelet GPCR subsets
Platelets, 2020 The principal demonstrated role of the nonvisual arrestins in vivo is to limit G protein-coupled receptor (GPCR) signaling. Nonetheless, a direct demonstration of this fundamental ability in platelets remains lacking, despite the prominent role played by
James L. Hutchinson +3 more
doaj +1 more source
Similarity between class A and class B G-protein-coupled receptors exemplified through calcitonin gene-related peptide receptor modelling and mutagenesis studies [PDF]
, 2012 Modelling class B G-protein-coupled receptors (GPCRs) using class A GPCR structural templates is difficult due to lack of homology. The plant GPCR, GCR1, has homology to both class A and class B GPCRs. We have used this to generate a class A–
Poyner, David +16 more
core +1 more source
Below the Surface: IGF-1R Therapeutic Targeting and Its Endocytic Journey
Cells, 2019 Ligand-activated plasma membrane receptors follow pathways of endocytosis through the endosomal sorting apparatus. Receptors cluster in clathrin-coated pits that bud inwards and enter the cell as clathrin-coated vesicles.
Caitrin Crudden +7 more
doaj +1 more source
GPCR-induced YAP activation sensitizes fibroblasts to profibrotic activity of TGFβ1
, 2020 Tissue fibrosis is a pathological condition characterized by uncontrolled fibroblast activation that ultimately leads to organ failure. The TGFβ1 pathway, one of the major players in establishment of the disease phenotype, is dependent on the ...
Diego Freti +23 more
core +1 more source
Vascular Biology, 2019 The discovery and extension of G-protein-coupled receptor (GPCR) transactivation-dependent signalling has enormously broadened the GPCR signalling paradigm.
Raafat Mohamed +9 more
doaj +1 more source
CHIMIA, 2021 Nervous system disorders affect millions of people around the world, through a very broad range of diseases. Here we describe our contribution to find a treatment for patients suffering from three of those diseases.
Hasane Ratni
doaj +1 more source
Development of PCR based approach to detect potential mosaicism in porcine embryos
Journal of Animal Reproduction and Biotechnology, 2020 Direct injection of genome editing tools such as CRISPR/Cas9 system into developing embryos has been widely used to generate genetically engineered pigs.
Jongki Cho +5 more
doaj +1 more source
Ligands can differentially and temporally modulate GPCR interaction with 14-3-3 isoforms
Current Research in Pharmacology and Drug Discovery, 2022 GPCR signaling and function depend on their associated proteins and subcellular locations. Besides G-proteins and β-arrestins, 14-3-3 proteins participate in GPCR trafficking and signaling, and they connect a large number of diverse proteins to form ...
Haifeng Eishingdrelo +4 more
doaj +1 more source
The Secretin GPCRs Descended from the Family of Adhesion GPCRs [PDF]
Molecular Biology and Evolution, 2008 The Adhesion G-protein-coupled receptors (GPCRs) are the most complex gene family among GPCRs with large genomic size, multiple introns, and a fascinating flora of functional domains, though the evolutionary origin of this family has been obscure. Here we studied the evolution of all class B (7tm2)-related genes, including the Adhesion, Secretin, and ...
Karl J V, Nordström +4 more
openaire +2 more sources