Results 1 to 10 of about 4,631 (116)

G Protein-Coupled Receptors in Osteoarthritis [PDF]

Frontiers in Endocrinology, 2022
Osteoarthritis (OA) is the most common chronic joint disease characterized, for which there are no available therapies being able to modify the progression of OA and prevent long-term disability. Critical roles of G-protein coupled receptors (GPCRs) have
Fanhua Wang, Mingyao Liu, Ning Wang, Jian Luo, Jian Luo   +4 more
doaj   +5 more sources

G protein-coupled receptors and obesity

Frontiers in Endocrinology, 2023
G protein-coupled receptors (GPCRs) have emerged as important drug targets for various chronic diseases, including obesity and diabetes. Obesity is a complex chronic disease that requires long term management predisposing to type 2 diabetes, heart ...
Alessandro Pocai
doaj   +3 more sources

Hemorphins Targeting G Protein-Coupled Receptors

Pharmaceuticals, 2021
Hemorphins are short peptides produced by the proteolysis of the beta subunit of hemoglobin. These peptides have diverse physiological effects especially in the nervous and the renin-angiotensin systems.
Mohammed Akli Ayoub, Ranjit Vijayan
doaj   +1 more source

Advances on Mrgprs itch receptors and their ligands

Pifu-xingbing zhenliaoxue zazhi, 2023
Although histamine is an important physiologically active substance in pruritus,antihistamine drugs can only relieve a small proportion of symptoms in chronic pruritus.
Jing HU, Zhijian CAO
doaj   +1 more source

Functional optimization of light-activatable Opto-GPCRs: Illuminating the importance of the proximal C-terminus in G-protein specificity

Frontiers in Cell and Developmental Biology, 2023
Introduction: G-protein coupled receptors (GPCRs) are the largest family of human receptors that transmit signals from natural ligands and pharmaceutical drugs into essentially every physiological process.
Siri Leemann, Sonja Kleinlogel
doaj   +1 more source

Atropine-functionalized gold nanoparticles binding to muscarinic receptors after passage across the intestinal epithelium

Royal Society Open Science, 2022
Gold nanoparticles have a high potential to be a treatment of diseases by their specific drug delivery properties and multivalent receptor stimulation.
Rebecca Claßen, Ervice Pouokam, Matthias Wickleder, Martin Diener, Annabelle Mattern   +4 more
doaj   +1 more source

Lysophospholipid G Protein-coupled Receptors [PDF]

Journal of Biological Chemistry, 2004
The many biological responses documented for lysophospholipids that include lysophosphatidic acid and sphingosine 1-phosphate can be mechanistically attributed to signaling through specific G protein-coupled receptors. At least nine receptors have now been identified, and the total number is likely to be larger.
Brigitte, Anliker, Jerold, Chun
openaire   +2 more sources

Constitutive Activity among Orphan Class-A G Protein Coupled Receptors. [PDF]

PLoS ONE, 2015
The purpose of this study was to evaluate the extent of constitutive activity among orphan class-A G protein coupled receptors within the cAMP signaling pathway.
Adam L Martin, Michael A Steurer, Robert S Aronstam   +2 more
doaj   +1 more source

Rules and mechanisms governing G protein coupling selectivity of GPCRs

Cell Reports, 2023
Summary: G protein-coupled receptors (GPCRs) convert extracellular stimuli into intracellular signaling by coupling to heterotrimeric G proteins of four classes: Gi/o, Gq, Gs, and G12/13.
Ikuo Masuho, Ryoji Kise, Pablo Gainza, Ee Von Moo, Xiaona Li, Ryosuke Tany, Hideko Wakasugi-Masuho, Bruno E. Correia, Kirill A. Martemyanov   +8 more
doaj   +1 more source

Evolution of vertebrate GnRH receptors from the perspective of a basal vertebrate

Frontiers in Endocrinology, 2012
This minireview provides the current status on gonadotropin-releasing hormone receptors (GnRH-R) in vertebrates, from the perspective of a basal vertebrate, the sea lamprey, and provides an evolutionary scheme based on the recent advance of whole genome ...
Stacia A Sower, Wayne A Decatur, Nerine T Joseph, Mihael eFreamat   +3 more
doaj   +1 more source