Results 21 to 30 of about 365,285 (265)
G Protein–Coupled Receptor Heteromers [PDF]
Annual Review of Pharmacology and Toxicology, 2016 G protein-coupled receptors (GPCRs) compose one of the largest families of membrane proteins involved in intracellular signaling. They are involved in numerous physiological and pathological processes and are prime candidates for drug development. Over the past decade, an increasing number of studies have reported heteromerization between GPCRs.
Gomes, Ivone +5 more
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Regulating G protein-coupled receptors by topological inversion
eLife, 2019 G protein-coupled receptors (GPCRs) are a family of proteins containing seven transmembrane helices, with the N- and C-terminus of the protein located at the extracellular space and cytosol, respectively.
Bray Denard +4 more
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Peptide ligand recognition by G protein-coupled receptors
Frontiers in Pharmacology, 2015 The past few years have seen spectacular progress in the structure determination of G protein-coupled receptors (GPCRs). We now have structural representatives from classes A, B, C, and F.
Brian E Krumm, Reinhard eGrisshammer
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G-Protein coupled receptors: answers from simulations
Beilstein Journal of Organic Chemistry, 2017 Molecular-dynamics (MD) simulations are playing an increasingly important role in research into the modes of action of G-protein coupled receptors (GPCRs).
Timothy Clark
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G Protein–Coupled Receptor Deorphanizations [PDF]
Annual Review of Pharmacology and Toxicology, 2013 G protein–coupled receptors (GPCRs) are major regulators of intercellular interactions. They initiate these actions by being activated by a wide variety of natural ligands. Historically, ligands were discovered first, but the advent of molecular biology reversed this trend.
Olivier, Civelli +5 more
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Presynaptic G Protein-Coupled Receptors: Gatekeepers of Addiction?
Frontiers in Cellular Neuroscience, 2016 Drug abuse and addiction cause widespread social and public health problems, and the neurobiology underlying drug actions and drug use and abuse is an area of intensive research.
Kari A Johnson, David M Lovinger
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G Protein-Coupled Receptors in Taste Physiology and Pharmacology
Frontiers in Pharmacology, 2020 Heterotrimeric G protein-coupled receptors (GPCRs) comprise the largest receptor family in mammals and are responsible for the regulation of most physiological functions.
Raise Ahmad, Julie E. Dalziel
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G-protein-coupled receptors at a glance [PDF]
Journal of Cell Science, 2003 [No abstract available]
Wesley K, Kroeze +2 more
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Signal Transduction of Sphingosine-1-Phosphate G Protein—Coupled Receptors
The Scientific World Journal, 2006 Sphingosine-1-phosphate (S1P) is a bioactive lipid capable of eliciting dramatic effects in a variety of cell types. Signaling by this molecule is by a family of five G protein—coupled receptors named S1P1–5 that signal through a variety of pathways to ...
Nicholas Young, James R. Van Brocklyn
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G Protein-Coupled Receptor Kinases Take Central Stage
Cells, 2022 The relevance of the family of G protein-coupled receptor kinases (GRKs) is based on its key participation in the regulation and intracellular dynamics of the largest family of membrane receptors, namely G protein-coupled receptors (GPCRs) [...]
Federico Mayor, Cristina Murga
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