Results 11 to 20 of about 83,092 (356)

GPCR photopharmacology

Molecular and Cellular Endocrinology, 2019
International audienceNew technologies for spatial and temporal remote control of G protein-coupled receptors (GPCRs) are necessary to unravel the complexity of GPCR signalling in cells, tissues and living organisms.
Font-Ingles, Joan, Font, Joan, Llebaria, Amadeu, Ricart-Ortega, Maria   +3 more
core   +4 more sources

PRED-GPCR: GPCR recognition and family classification server [PDF]

Nucleic Acids Research, 2004
The vast cell-surface receptor family of G-protein coupled receptors (GPCRs) is the focus of both academic and pharmaceutical research due to their key role in cell physiology along with their amenability to drug intervention.
Promponas, VJ, Papasaikas, PK, Hamodrakas, SJ, Bagos, PG, Litou, ZI   +4 more
core   +4 more sources

GPCRs and cancer [PDF]

Acta Pharmacologica Sinica, 2012
G-protein-coupled receptors (GPCRs), which represent the largest gene family in the human genome, play a crucial role in multiple physiological functions as well as in tumor growth and metastasis. For instance, various molecules like hormones, lipids, peptides and neurotransmitters exert their biological effects by binding to these seven-transmembrane ...
Lappano R, MAGGIOLINI, Marcello
openaire   +3 more sources

GPCR-FEX: A Fluoride-Based Selection System for Rapid GPCR Screening and Engineering

, 2022
The directed evolution of proteins comprises a search of sequence space for variants that improve a target phenotype, yet identification of desirable variants is inherently limited by library size and screening ability.
Tejas A. Navaratna (11896707), Michelle A. O’Malley, Justin I. Yoo, Justin I. Yoo (5482058), Tejas A. Navaratna, Michelle A. O’Malley (1444552), Patrick Kolence (11896710), Patrick Kolence   +7 more
core   +1 more source

Nutrient sensing and cAMP signaling in yeast: G-protein coupled receptor versus transceptor activation of PKA

Microbial Cell, 2020
A major signal transduction pathway regulating cell growth and many associated physiological properties as a function of nutrient availability in the yeast Saccharomyces cerevisiae is the protein kinase A (PKA) pathway.
Griet Van Zeebroeck, Liesbeth Demuyser, Zhiqiang Zhang, Ines Cottignie, Johan M. Thevelein   +4 more
doaj   +1 more source

Nuclear localization of histamine receptor 2 in primary human lymphatic endothelial cells

Biology Open, 2022
Histamine exerts its physiological functions through its four receptor subtypes. In this work, we report the subcellular localization of histamine receptor 2 (H2R), a G protein-coupled receptor (GPCR), which is expressed in a wide variety of cell and ...
Sarit Pal, Anatoliy Gashev, Debarshi Roy
doaj   +1 more source

Ubiquitination of GPCRs [PDF]

, 2011
In this chapter, we describe a method for detecting the ubiquitination status of G protein-coupled receptors (GPCRs). This involves co-expression of a GPCR with an epitope-tagged ubiquitin construct in a -heterologous mammalian expression system. Stimulus-dependent modification of the GPCR by -ubiquitin is detected by immunoprecipitation and subsequent
Adriana, Caballero, Adriano, Marchese
openaire   +2 more sources

GPCR-OKB: the G protein coupled receptor oligomer knowledge base [PDF]

, 2010
Rapid expansion of available data about G Protein Coupled Receptor (GPCR) dimers/oligomers over the past few years requires an effective system to organize this information electronically.
Bas Vroling, Pin, J.-P., Palczewski, K., Camacho-Artacho, Marta, Pin, J.P., Lucy Skrabanek, Jean-Philippe Pin, Marta Camacho-Artacho, Devi, Lakshmi A, Graeme Milligan, Marta Filizola, Campagne, Fabien, Fabien Campagne, Martin J. Lohse, Jufang Shan, Lohse, Martin J, Vriend, Gerrit, Khelashvili, George, Milligan, Graeme, Camacho-Artacho, M., Skrabanek, L., George Khelashvili, Campagne, F., Susan R. George, Lakshmi A. Devi, Filizola, M., Pin, Jean-Philippe, Vroling, B., Bouvier, M., Devi, L.A., Richard R. Neubig, Marc Parmentier, George, Susan R, Palczewski, Krzysztof, Dorff, K., Shan, J., Vriend, G., Michel Bouvier, Lohse, M.J., Bouvier, Michel, Skrabanek, Lucy, Vroling, Bas, Filizola, Marta, Neubig, Richard R, Gerrit Vriend, Dorff, Kevin, Parmentier, Marc, Khelashvili, G., Javitch, J.A., Shan, Jufang, Parmentier, M., Javitch, Jonathan A, Krzysztof Palczewski, Kevin Dorff, Jonathan A. Javitch, George, S.R., Neubig, R.R., Milligan, G.   +57 more
core   +1 more source

GPCRTree: online hierarchical classification of GPCR function [PDF]

, 2008
Background: G protein-coupled receptors (GPCRs) play important physiological roles transducing extracellular signals into intracellular responses. Approximately 50% of all marketed drugs target a GPCR.
Davies Matthew N, Clark, Edward, Halling-Brown Mark, Flower Darren R, Moss, David S., Alex A Freitas, Halling-Brown, Mark D., Clark, E., Timmis Jon, Flower, Darren R, Andrew Secker, Freitas, Alex A., Timmis, J., Davies, M.N., David S Moss, Secker, Andrew D., Secker, A., Halling-Brown, Mark, Moss David S, Timmis, Jon, Freitas, A.A., Mark Halling-Brown, Clark Edward, Secker Andrew, Secker, Andrew, Flower, Darren R., Jon Timmis, Edward Clark, Matthew N Davies, Freitas Alex A, Davies, Matthew N., Darren R Flower, Flower, D.R.   +32 more
core   +1 more source

Molecular Cloning and Expression of Human Regulators of G-Protein Signaling 4, 5, and 16

McGill Journal of Medicine, 2020
N ...
Aravind Athiviraham
doaj   +1 more source