Alterations in Dendritic Spine Maturation and Neurite Development Mediated by FAM19A1
Cells, 2021 Neurogenesis and functional brain activity require complex associations of inherently programmed secretory elements that are regulated precisely and temporally.
Hyo-Jeong Yong +2 more
doaj +1 more source
Advances in GPCR modeling evaluated by the GPCR Dock 2013 assessment: meeting new challenges. [PDF]
, 2014 Despite tremendous successes of GPCR crystallography, the receptors with available structures represent only a small fraction of human GPCRs. An important role of the modeling community is to maximize structural insights for the remaining receptors and ...
Kufareva I +5 more
core +4 more sources
Bioinformatics Analysis of the Melanocortin 1 Receptor Gene (MC1R) in the Southern Platyfish Xiphophorus maculatus (Günther, 1866) [PDF]
International Journal Bioautomation, 2020 The Southern platyfish Xiphophorus maculatus is one of the most popular ornamental fish used widely as a premier model system in understanding the genetic basis of color pattern polymorphism. Coloration in X.
Abdul Khader Sultan Mohideen, Anbu Arun
doaj +1 more source
LPA1-mediated inhibition of CXCR4 attenuates CXCL12-induced signaling and cell migration
Cell Communication and Signaling, 2023 Background G protein-coupled receptor heteromerization is believed to exert dynamic regulatory impact on signal transduction. CXC chemokine receptor 4 (CXCR4) and its ligand CXCL12, both of which are overexpressed in many cancers, play a pivotal role in ...
Jong Min Hong +4 more
doaj +1 more source
Scientific Reports, 2023 C-X-C chemokine receptor 4 (CXCR4) is widely overexpressed in various types of cancer and is involved in several cancer phenotypes including tumor growth, survival, and metastasis.
Chulo Park +5 more
doaj +1 more source
Uncovering G Protein-Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis. [PDF]
Ann Clin Transl NeurolABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Yang J, Zhang D, Liu D, Lin D, Wang H.
europepmc +2 more sources
BiasNet: A model to predict ligand bias towards GPCR signaling [PDF]
, 2021 Signaling bias is a feature of many G–protein coupled receptor (GPCR) modulating drugs with clinical implications. Whether it is therapeutically advantageous for a drug to be G Protein biased or β-Arrestin (β-Arr) biased, depends on the context of the ...
Govinda, KC +4 more
core +1 more source
Heparin-bound chemokine CXCL8 monomer and dimer are impaired for CXCR1 and CXCR2 activation: implications for gradients and neutrophil trafficking [PDF]
Open Biology, 2017 Chemokine CXCL8 plays a pivotal role in host immune response by recruiting neutrophils to the infection site. CXCL8 exists as monomers and dimers, and mediates recruitment by interacting with glycosaminoglycans (GAGs) and activating CXCR1 and CXCR2 ...
Prem Raj B. Joseph +2 more
doaj +1 more source
A Benchmark for Accurate GPCR Ligand Binding Affinity Prediction with Free Energy Perturbation [PDF]
, 2023 G protein-coupled receptors (GPCRs) are among the most important drug targets in the pharmaceutical industry. Free energy perturbation (FEP), which can accurately predict the relative binding free energies of drug molecules, is now widely used in drug ...
Yu, Zhou +9 more
core +1 more source
Patriarchi/GPCR-based_GEFIs_Applications: GPCR-based_GEFIs_Applications
, 2023 Repository of studies using GPCR-based GEFIs from May 2018 until Sep ...
Patriarchi Lab
core +1 more source