Results 41 to 50 of about 83,092 (356)

Agonist and antagonist TRUPATH assays for G protein-coupled receptors

STAR Protocols, 2022
Summary: TRUPATH is a bioluminescence resonance energy transfer-based platform for quantifying G protein-coupled receptor activity via dissociation of heterotrimeric G protein biosensors.
Jeffrey F. DiBerto, Katie Smart, Reid H.J. Olsen, Bryan L. Roth   +3 more
doaj   +1 more source

Odorant receptors can mediate axonal identity and gene choice via cAMP-independent mechanisms [PDF]

Open Biology, 2016
Odorant receptors (ORs) control several aspects of cell fate in olfactory sensory neurons (OSNs), including singular gene choice and axonal identity.
Kiavash Movahedi, Xavier Grosmaitre, Paul Feinstein   +2 more
doaj   +1 more source

GPCRs

, 2021
This presentation is about ...
Donya Salehi, Seyed amin motohamelian, Mostafa Shir Mohammadi   +2 more
openaire   +2 more sources

Genetically encoded fluorescent biosensors for GPCR research

Frontiers in Cell and Developmental Biology, 2022
G protein-coupled receptors (GPCRs) regulate a wide range of physiological and pathophysiological cellular processes, thus it is important to understand how GPCRs are activated and function in various cellular contexts.
Hyunbin Kim, Hyunbin Kim, In-Yeop Baek, In-Yeop Baek, Jihye Seong, Jihye Seong, Jihye Seong   +6 more
doaj   +1 more source

pdCSM-GPCR: predicting potent GPCR ligands with graph-based signatures.

, 2022
MOTIVATION: G protein-coupled receptors (GPCRs) can selectively bind to many types of ligands, ranging from light-sensitive compounds, ions, hormones, pheromones and neurotransmitters, modulating cell physiology.

core   +1 more source

Burixafor, a CXCR4 inhibitor with a differentiated kinetics profile: results of a phase 2 study for rapid cell mobilization in multiple myeloma and lymphoma patients undergoing transplant

Annals of Hematology
Inhibitors of C-X-C chemokine receptor type 4 (CXCR4) are standard of care for mobilization of hematopoietic stem and progenitor cells (HPC) in transplant eligible patients with hematological malignancies or undergoing HPC-based gene therapies. Burixafor
Devki D. Sukhtankar, Pina M. Cardarelli, Bita Jalilizeinali, Gayatri Setia, GaYeon Kim, Li-wen Chang, Cheng-yuan Tsai, Niña G. Caculitan, Michael W. Schuster   +8 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Multiplexed selectivity screening of anti-GPCR antibodies

, 2023
G protein-coupled receptors (GPCRs) control critical cellular signaling pathways. Therapeutic agents including anti-GPCR antibodies (Abs) are being developed to modulate GPCR function.
Ilana B. Kotliar, Tea Dodig-Crnković, Schwenk, Jochen M., Uhlen, Mathias, Kotliar, Ilana B., Mathias Uhlén, Jochen M. Schwenk, Arne Elofsson, Fromm, Samuel,, Sakmar, Thomas P., Samuel Fromm, Dahl, Leo, Leo Dahl, Bendes, Annika, Elofsson, Arne,, Annika Bendes, Dodig-Crnkovic, Tea, Thomas P. Sakmar   +17 more
core   +1 more source

Neuropeptide GPCRs in Neuroendocrinology [PDF]

Frontiers in Endocrinology, 2014
The human genome encompasses ~ 860 G protein-coupled receptors (GPCRs) including 374 non-chemosensory GPCRs. Half of these latter GPCRs recognize (neuro)peptides as natural ligands. GPCRs thus play a pivotal role in neuroendocrine communication. In particular, GPCRs are involved in the neuroendocrine control of feeding behavior, reproduction, growth ...
Vaudry, Hubert, Seong, Jae Young
openaire   +3 more sources