Results 61 to 70 of about 81,481 (258)

The role of the metabotropic glutamate receptor 1 signaling pathway in the development of cardiovascular pathology

Рациональная фармакотерапия в кардиологии
Metabotropic glutamate receptor 1 (mGluR1), traditionally studied in the context of neuronal signaling, has recently gained attention as a potential contributor to the pathogenesis of cardiovascular diseases.
A. R. Levshina, N. G. Gumanova, L. V. Voskanian, A. S. Shanoyan, D. K. Vasiliev, O. M. Drapkina   +5 more
doaj   +1 more source

Neuromodulators and Long-Term Synaptic Plasticity in Learning and Memory: A Steered-Glutamatergic Perspective

Brain Sciences, 2019
The molecular pathways underlying the induction and maintenance of long-term synaptic plasticity have been extensively investigated revealing various mechanisms by which neurons control their synaptic strength.
Amjad H. Bazzari, H. Rheinallt Parri
doaj   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Ontogeny of the specificity of gonadotropin receptors and gene expression in carp

Endocrine Connections, 2019
The pituitary gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), are the principle endocrine drivers of reproductive processes in the gonads of jawed vertebrates.
Lian Hollander-Cohen, Benjamin Böhm, Krist Hausken, Berta Levavi-Sivan   +3 more
doaj   +1 more source

Akt acts as a switch for GPCR transactivation of the TGF‐β receptor type 1

, 2021
Transforming growth factor (TGF)-β signalling commences with the engagement of TGF-β ligand to cell surface TGF-β receptors (TGFBR) stimulating Smad2 carboxyl-terminal phosphorylation (phospho-Smad2C) and downstream biological responses.
Walter G. Thomas, Gabr, Mai, Kamato, Danielle, Raafat Mohamed, Thomas, Walter G, Aravindra Shajimoon, Rizwana Afroz, Mohamed, Raafat, Afroz, Rizwana, Little, Peter J, Shajimoon, Aravindra, Mai Gabr, Peter J. Little, Danielle Kamato   +13 more
core   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC

Hepatology, EarlyView., 2022
Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu, Bingqing Xu, Xiaodong Wang, Wen‐Hua Wan, Jinying Lu, Deyuan Kong, Yu Jin, Wenhua You, Hua Sun, Xiaoxin Mu, Dongju Feng, Yun Chen   +11 more
wiley   +1 more source

Malignant progression of liver cancer progenitors requires lysine acetyltransferase 7–acetylated and cytoplasm‐translocated G protein GαS

Hepatology, EarlyView., 2022
KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou, Kaiwei Jia, Suyuan Wang, Zhenyang Li, Yunhui Li, Shan Lu, Yingyun Yang, Liyuan Zhang, Mu Wang, Yue Dong, Luxin Zhang, Wannian Zhang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou   +15 more
wiley   +1 more source

What Makes Antibodies Against G Protein-Coupled Receptors so Special? A Novel Concept to Understand Chronic Diseases

Frontiers in Immunology, 2020
Expressions of G protein-coupled receptors (GPCR) on immune and tissue resident cells are the consequence of the cellular environment, which is highly variable.
Gabriela Riemekasten, Gabriela Riemekasten, Gabriela Riemekasten, Gabriela Riemekasten, Frank Petersen, Frank Petersen, Frank Petersen, Harald Heidecke   +7 more
doaj   +1 more source

ATP‐Mediated Bidirectional Communication Between Natural and Artificial Cells for Controlled Bioreactions

Advanced Functional Materials, EarlyView.
Establishment of bidirectional communication behavior between natural and artificial cells. The first type of communication from natural dendritic cells to artificial polymeric cells was achieved via ATP release after cell lysis. The released ATP was taken up via gated UV‐controlled permeability increase of the polymeric membrane for performing ...
Ilona Kalte, Tsvetomir Ivanov, Leonhard Seufert, Shoupeng Cao, Lucas Caire da Silva, Volker Mailänder, Katharina Landfester   +6 more
wiley   +1 more source