Results 81 to 90 of about 83,092 (356)
Nature Communications, 2022 GPCR kinases (GRKs) regulate GPCR interactions and thus functions. Here, the authors report a comprehensive panel of GRK knockout cells, used to assess the GRK-specific β-arrestin recruitment. Selective engagement of GRKs induces distinct GPCR–β-arrestin
J. Drube +15 more
doaj +1 more source
Advanced Science, EarlyView.Corneal nerve regeneration is critical to corneal wound healing processes. The current study reveals a novel role of MG53 in promoting corneal nerve regeneration after alkali induced injury. Mechanistically, MG53 enters macrophages via its receptor, MPEG1, promotes MVP K63 ubiquitination, and triggers STAT6 induced repair‐related genes expression ...
Peng Chen +14 more
wiley +1 more source
Discovery of Pathologic GPCR Aggregation [PDF]
, 2019 The family of G-protein-coupled receptors (GPCRs) is one of the most important drug targets. Mechanisms underlying GPCR activation and signaling are therefore of great pharmacologic interest. It was long thought that GPCRs exist and function as monomers.
Ursula Quitterer, Said AbdAlla
core +3 more sources
Deep hierarchical embedding for simultaneous modeling of GPCR proteins in a unified metric space
Scientific Reports, 2021 GPCR proteins belong to diverse families of proteins that are defined at multiple hierarchical levels. Inspecting relationships between GPCR proteins on the hierarchical structure is important, since characteristics of the protein can be inferred from ...
Taeheon Lee +3 more
doaj +1 more source
Advanced Science, EarlyView.This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon +21 more
wiley +1 more source
Hierarchical classification of G-protein-coupled receptors with a PSO/ACO algorithm [PDF]
, 2006 In our previous work we have proposed a hybrid Particle Swarm Optimisation / Ant Colony Optimisation (PSO/ACO) algorithm for discovering classification rules.
Holden, Nicholas, Freitas, Alex A.
core
Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing
Advanced Science, EarlyView.Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale +6 more
wiley +1 more source
Identifying GPCR-drug interaction based on wordbook learning from sequences
BMC Bioinformatics, 2020 Background G protein-coupled receptors (GPCRs) mediate a variety of important physiological functions, are closely related to many diseases, and constitute the most important target family of modern drugs.
Pu Wang +3 more
doaj +1 more source
, 2017 List of names and terms of proteins known to interact with GPCRs.
Ming-Ying Leung (76155) +4 more
core +1 more source