Results 101 to 110 of about 81,481 (258)

Editorial: Insights in cellular endocrinology: 2022

Frontiers in Endocrinology, 2023
Ralf Jockers, Oreste Gualillo
doaj   +1 more source

Regulation of CXCR4 function by S1P1 through heteromerization

Cell Communication and Signaling
Background The trafficking of immune cells between lymphoid organs and circulation depends on gradients of CXCL12 and sphingosine-1-phosphate (S1P), mediated through their cognate receptors C-X-C chemokine receptor type 4 (CXCR4) and S1P receptor type 1 (
Hyun-Tae Kim, Jae-Yeon Jeong, Won-Ki Huh
doaj   +1 more source

GPCR sorting at multivesicular endosomes [PDF]

, 2015
The lysosomal degradation of G protein-coupled receptors (GPCRs) is essential for receptor signaling and down regulation. Once internalized, GPCRs are sorted within the endocytic pathway and packaged into intraluminal vesicles (ILVs) that bud inward to ...
Michael Robert Dores, JoAnn Trejo, Trejo, JoAnn, Dores, Michael Robert   +3 more
core   +1 more source

Computational Prediction of GPCR Oligomerisation [PDF]

, 2019
There has been a recent and prolific expansion in the number of GPCR crystal structures being solved: in both active and inactive forms and in complex with ligand, with G protein and with each other.
Townsend-Nicholson, A
core   +1 more source

Activation of the pituitary adenylate cyclase-activating polypeptide type I receptor promotes neuroblastoma proliferation and migration through distinct G protein pathways

Cell Communication and Signaling
The pituitary adenylate cyclase-activating polypeptide type I receptor (PAC1R) is a class B G protein-coupled receptor implicated in a variety of physiological and pathological processes, including cancer.
Sarah Jang, Jae-Yeon Jeong, Won-Ki Huh
doaj   +1 more source

The structure of dynamic GPCR signaling networks

, 2013
G protein coupled receptors (GPCRs) stimulate signaling networks that control a variety of critical physiological processes. Static information on the map of interacting signaling molecules at the basis of many cellular processes exists, but little is ...
Giri, Lopamudra, Karunarathne, Ajith, Neill, P, Janardhanan, V   +3 more
core  

GPCR photopharmacology

, 2019
International audienceNew technologies for spatial and temporal remote control of G protein-coupled receptors (GPCRs) are necessary to unravel the complexity of GPCR signalling in cells, tissues and living organisms.
Font-Ingles, Joan, Font, Joan, Llebaria, Amadeu, Ricart-Ortega, Maria   +3 more
core   +1 more source

Data-driven score tuning for ChooseLD: A structure-based drug design algorithm with empirical scoring and evaluation of ligand–protein docking predictability

Biophysics and Physicobiology
Computerized molecular docking methodologies are pivotal in in-silico screening, a crucial facet of modern drug design. ChooseLD, a docking simulation software, combines structure- and ligand-based drug design methods with empirical scoring.
Akihiro Masuda, Daichi Sadato, Mitsuo Iwadate   +2 more
doaj   +1 more source

Von In‐Silico bis In‐Cerebro – Entwicklung des Orexinrezeptor Antagonisten „Photorexant“ zur Photomodulation In Vitro und im Gehirn der Maus

Angewandte Chemie, EarlyView.
Durch einen strukturbasierten Designansatz wurden photoschaltbare Derivate des von der FDA zugelassenen Arzneistoffes Suvorexant entwickelt, gedockt, synthetisiert und pharmakologisch an den Orexin‐1‐ und 2‐Rezeptoren (OX1R und OX2R) charakterisiert.
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source

PRED-GPCR: GPCR recognition and family classification server

, 2004
The vast cell-surface receptor family of G-protein coupled receptors (GPCRs) is the focus of both academic and pharmaceutical research due to their key role in cell physiology along with their amenability to drug intervention.
Promponas, VJ, Papasaikas, PK, Hamodrakas, SJ, Bagos, PG, Litou, ZI   +4 more
core   +1 more source