Results 111 to 120 of about 81,481 (258)

A new variant of lumpy skin disease virus circulating in Vietnam based on sequencing analysis of GPCR gene

Open Veterinary Journal
Background: In 2021, Vietnam experienced an outbreak of Lumpy skin disease (LSD), which infected 207,687 cattle and buffaloes, as officially reported, and resulted in the culling of 29,182 animals.
Ha Thi Thanh Tran, Anh Duc Truong, Anh Tuan Tran, Nhu Thi Chu, Vinh The Nguyen, Hoang Vu Dang   +5 more
doaj   +1 more source

Binding kinetics of ligands acting at GPCRs [PDF]

, 2019
The influence of drug-receptor binding kinetics has often been overlooked during the development of new therapeutics that target G protein-coupled receptors (GPCRs).
Kilpatrick, Laura E., Hill, Stephen J., Stoddart, Leigh A., Sykes, David A.   +3 more
core   +1 more source

Transmembrane receptors (GPCR) [PDF]

, 2016
GPCR (receptori na koje su vezani G-proteini) čine obitelj receptora sa sedam transmembranskih zavojnica (7TM receptori) koji prenose izvanstanični signal aktivirajući unutrastanične molekule, poznate pod nazivom sekundarni glasnici, koje su posrednici u
Sladić, Kristina
core   +1 more source

An examination of how Rab GTPases and molecular chaperones influence plasma membrane expression of chemokine receptor dimers

, 2013
Signal termination processes of GPCRs are well established, unlike processes that regulate the assembly and intracellular trafficking of these signaling complexes.
Gillies, Kelsie
core  

GPCR-BERT: Interpreting Sequential Design of G Protein-Coupled Receptors Using Protein Language Models

With the rise of transformers and large language models (LLMs) in chemistry and biology, new avenues for the design and understanding of therapeutics have been opened up to the scientific community.
Seongwon Kim (2029453), Amir Barati Farimani (7822376), Parisa Mollaei (7484450), Akshay Antony (17943907), Rishikesh Magar (9636817)   +4 more
core   +1 more source

Expanding the Concept of G Protein-Coupled Receptor (GPCR) Dimer Asymmetry towards GPCR-Interacting Proteins

, 2011
G protein-coupled receptors (GPCRs), major targets of drug discovery, are organized in dimeric and/or oligomeric clusters. The minimal oligomeric unit, the dimer, is composed of two protomers, which can behave differently within the dimer.
Pascal Maurice, Ralf Jockers, Maud Kamal, Jockers, Ralf, Kamal, Maud, Maurice, Pascal   +5 more
core   +1 more source

In Silico to In Cerebro—Development of the Orexin Receptor Antagonist “Photorexant” for Photomodulation In Vitro and in Mouse Brains

Angewandte Chemie International Edition, EarlyView.
Following a structure‐based design approach, photoswitchable derivatives of the FDA‐approved drug suvorexant were designed, docked, synthesized, and characterized pharmacologically at the orexin 1 and 2 receptors (OX1R and OX2R). Optimized “photorexant” showed up to an 11‐fold difference in IC50 between photoisomers, enabled dynamic and reversible ...
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source

Gut Health in Ostriches (Struthio camelus): Insights Into Intestinal Structure, Functions, Microbiome, and Improvement Strategies

Animal Research and One Health, EarlyView.
Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang, Fang‐Fang Guo, Wen‐Juan Du, Meng Li, Aftab Shaukat, Zhu‐Qing Jia, Shu‐Cheng Huang   +6 more
wiley   +1 more source

Antagonist binding and induced conformational dynamics of GPCR A2A adenosine receptor

, 2013
Antagonist binding and induced conformational dynamics of GPCR A2A adenosine ...
韩克利, 杨明俊, 庞雪芹
core  

Enhancing Meat Quality Through Dietary Fiber: Insights Into the Gut Microbiota‐Derived Short‐Chain Fatty Acids‐Muscle Axis

Animal Research and One Health, EarlyView.
Dietary fiber (DF) modulates meat quality through the gut‐muscle axis by reshaping gut microbiota, improving intestinal integrity, reducing inflammation, and regulating muscle metabolism. These mechanisms influence muscle fiber characteristics and post‐mortem biochemistry, thereby enhancing tenderness, juiciness, color, flavor, and nutritional value of
Zeshan Zulfiqar, Muhammad Arslan Asif, Layla Al‐Mitib, Nabeela Ashiq, Haojie Wang, Yalei Cui, Boshuai Liu, Shucheng Huang, Yinghua Shi   +8 more
wiley   +1 more source