Results 121 to 130 of about 83,092 (356)

Rational design of dualsteric GPCR ligands: quests and promise [PDF]

, 2010
Klaus Mohr, Christian Tränkle, Evi Kostenis, Elisabetta Barocelli, Marco De Amici, Ulrike Holzgrabe   +5 more
openalex   +1 more source

GPCR-BERT: Interpreting Sequential Design of G Protein-Coupled Receptors Using Protein Language Models

With the rise of transformers and large language models (LLMs) in chemistry and biology, new avenues for the design and understanding of therapeutics have been opened up to the scientific community.
Seongwon Kim (2029453), Amir Barati Farimani (7822376), Parisa Mollaei (7484450), Akshay Antony (17943907), Rishikesh Magar (9636817)   +4 more
core   +1 more source

Expanding the Concept of G Protein-Coupled Receptor (GPCR) Dimer Asymmetry towards GPCR-Interacting Proteins

, 2011
G protein-coupled receptors (GPCRs), major targets of drug discovery, are organized in dimeric and/or oligomeric clusters. The minimal oligomeric unit, the dimer, is composed of two protomers, which can behave differently within the dimer.
Pascal Maurice, Ralf Jockers, Maud Kamal, Jockers, Ralf, Kamal, Maud, Maurice, Pascal   +5 more
core   +1 more source

Quantum Phenomena in Molecular and Biological Systems: A Decoherence‐Based Decision Framework With Falsifiable Predictions and a Failure‐Mode Taxonomy

Advanced Physics Research, EarlyView.
A physics‐grounded framework based on decoherence timescales (τ_dec vs τ_func), Markovian validity, and falsifiability criteria is applied across molecular systems to distinguish where quantum effects are necessary, marginal, or irrelevant. The analysis integrates quantum chemistry, biological quantum mechanisms, and quantum computing under a unified ...
Sarfaraz K. Niazi
wiley   +1 more source

Antagonist binding and induced conformational dynamics of GPCR A2A adenosine receptor

, 2013
Antagonist binding and induced conformational dynamics of GPCR A2A adenosine ...
韩克利, 杨明俊, 庞雪芹
core  

The G Protein-Coupled Receptor Heterodimer Network (GPCR-HetNet) and Its Hub Components [PDF]

, 2014
Dasiel Borroto-Escuela, Ismel Brito, Wilber Romero‐Fernandez, Michael Di Palma, Julia Oflijan, Kamila Skieterska, Jolien Duchou, Kathleen Van Craenenbroeck, Diana Suárez‐Boomgaard, Alicia Rivera, Diego Guidolin, Luigi F. Agnati, Kjell Fuxé   +12 more
openalex   +1 more source

Modulating Taste Perception in Newly Weaned Piglets: The Role of Palatability Additives in Enhancing Feed Intake and Performance

Animal Research and One Health, EarlyView.
Palatability enhancers modulate taste and smell, increasing feed acceptance, reducing weaning stress, and improving piglet performance. ABSTRACT The continuous growth of global agribusiness stimulates the search for alternatives that can enhance the performance and quality of life of production animals.
Luana Specht, Gabriela Altenhofen, Daiane Carvalho, Michele Fangmeier   +3 more
wiley   +1 more source

The Application of Artificial Intelligence Accelerates G Protein-Coupled Receptor Ligand Discovery

Engineering
G protein-coupled receptors (GPCRs) are crucial players in various physiological processes, making them attractive candidates for drug discovery. However, traditional approaches to GPCR ligand discovery are time-consuming and resource-intensive.
Wei Chen, Chi Song, Liang Leng, Sanyin Zhang, Shilin Chen   +4 more
doaj   +1 more source

Computational Prediction of GPCR Oligomerisation [PDF]

, 2019
There has been a recent and prolific expansion in the number of GPCR crystal structures being solved: in both active and inactive forms and in complex with ligand, with G protein and with each other.
Townsend-Nicholson, A
core  

Structure of Class B GPCRs: new horizons for drug discovery [PDF]

, 2014
Andrea Bortolato, A.S. Dore, Kaspar Hollenstein, Benjamin G. Tehan, Jonathan S. Mason, Fiona H. Marshall   +5 more
openalex   +1 more source