Results 141 to 150 of about 81,481 (258)
Food Safety and Health, EarlyView.In this review, we critically summarized the application of natural polysaccharides (NPs) for the treatment of IBD. This approach combines, in a unique way (right), the basic structure–activity relationships of NPs from different origins (left) with their multipronged mode of action, which involves modulation of the gut microbiota and other ...
Felix Danso +3 more
wiley +1 more source
Structure and Function of GPCR Dimer
Shengwu huaxue yu shengwu wuli jinzhanG-protein coupled receptors (GPCRs) are an essential family of proteins on the cell membrane, widely distributed in various types of tissues and cells. Typical GPCRs are composed of characteristic 7 transmembrane α-helix domains, extracellular domain ...
LI Chuan-Bao, LI Chen-Hui, XUE Li
doaj +1 more source
Sub 3Å cryoEM structure using a standard LaB6 120kV TEM upgraded with direct electron detector [PDF]
BIO Web of ConferencesVenugopal Hari +7 more
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Serotonin neuromicrobiology: Psychobiotic modulation of the gut–brain axis for mental health
Ibrain, EarlyView.An overview of Psychobiotics and Tryptophan metabolism: A serotonin‐kynurenine crosstalk shaping the Gut‐Brain axis. IDO1, Indoleamine 2,3‐dioxygenase 1; 5‐HT3, 5‐hydroxytryptamine type 3; IFN‐γ, Interferon‐gamma; TNF‐α, Tumor necrosis factor‐alpha; IL‐1β, Interleukin‐1 beta; IL‐6, Interleukin 6; Trp, Tryptophan; 5‐HT, 5‐hydroxy‐tryptamine; 5‐HTP, 5 ...
Nidhi Mandloi +4 more
wiley +1 more source
AI-driven GPCR analysis, engineering, and targeting
This article investigates the role of recent advances in Artificial Intelligence (AI) to revolutionise the study of G protein-coupled receptors (GPCRs). AI has been applied to many areas of GPCR research, including the application of machine learning (ML)
Velloso, JPL +3 more
core +1 more source
The Endothelial CXCR Family in Vascular Health and Disease
iNew Medicine, EarlyView.ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu +4 more
wiley +1 more source
Metrnl: A Novel Therapeutic Target in Atherosclerosis
iNew Medicine, EarlyView.ABSTRACT Atherosclerosis is a chronic inflammatory vascular disease and the main pathological basis of cardiovascular and cerebrovascular events. Exploration of endogenous protective factors in the disease is beneficial for the establishment of new therapeutic strategies.
Pin Wang, Dao‐Xin Wang, Chao‐Yu Miao
wiley +1 more source
SNX9 family mediates βarrestin-independent GPCR endocytosis
Agonist-stimulated GPCR endocytosis typically occurs via the multi-faceted adaptor proteins known as βarrestins. However, endocytosis of several GPCRs occurs independently of β-arrestins, suggesting an additional mode of GPCR endocytosis, but the ...
Adriano Marchese +4 more
core +1 more source
Laser &Photonics Reviews, EarlyView.Optical neuromodulation with IR light allows stimulation of the PNS without the need for physical contact with the target nerve or without requiring any genetic modification. The clinical translation of this technique will pave the way to the development of neural interfaces for restoring sensory feedback in individuals with limb amputation.
Federica Piccirillo +20 more
wiley +1 more source
Editorial: GPCR and G Protein-Mediated Signalling Events in the Nervous System
Frontiers in Cellular Neuroscience, 2022 Yamina A. Berchiche, Terence E. Hébert
doaj +1 more source