Cigarette Smoke Exposure Attenuates T2R‐Mediated Apoptosis in Head and Neck Squamous Cell Carcinoma
Head &Neck, EarlyView.ABSTRACT Background Tobacco use is associated with worse outcomes in head and neck squamous cell carcinoma (HNSCC). Bitter taste receptor (T2R) activation induces apoptosis via calcium‐dependent signaling, and higher T2R expression correlates with increased survival in HNSCC.
Kyle Polen +10 more
wiley +1 more source
, 2016 <p>KRIPO stands for Key Representation of Interaction in POckets, see <a href="http://dx.doi.org/10.1186/1758-2946-6-S1-O26">reference</a> for more information.</p> <p>Subset of Kripo fragments and distance matrix of ...
Marton Vass +4 more
core +1 more source
Neoceptors: reengineering GPCRs to recognize tailored ligands
, 2007 Kenneth A. Jacobson +2 more
openalex +2 more sources
Erratum: An allosteric role for receptor activity-modifying proteins in defining GPCR pharmacology [PDF]
, 2016 Joseph J. Gingell +7 more
openalex +1 more source
SNX9 family mediates βarrestin-independent GPCR endocytosis
Agonist-stimulated GPCR endocytosis typically occurs via the multi-faceted adaptor proteins known as βarrestins. However, endocytosis of several GPCRs occurs independently of β-arrestins, suggesting an additional mode of GPCR endocytosis, but the ...
Adriano Marchese +4 more
core +1 more source
Controlling GPCR Rhodopsin Function by Small, Physiologically Relevant Changes in Bilayer Hydrophobic Thickness [PDF]
, 2016 Olivier Soubias +4 more
openalex +1 more source
Class-Switching of B Lymphocytes by DNA and Cell Immunization for Stereospecific Monoclonal Antibodies against Native GPCR [PDF]
, 2021 Yushi Isozaki +2 more
openalex +1 more source
The role of human microbiota in breast cancer pathogenesis and treatment
iMeta, EarlyView.The human microbiota contributes to breast cancer pathogenesis and treatment response through interactions involving the oral, gut, and breast microbial niches. (Left) Multi‐site dysbiosis is characterized by altered microbial composition and abundance across different anatomical sites.
Jie Qiu +9 more
wiley +1 more source
A systems and molecular analysis of G protein-mediated signalling [PDF]
The ability of cells to respond correctly to signals from their microenvironment is an essential prerequisite of life. Many external signals are detected through G protein-coupled receptor (GPCR) signalling pathways, which control all aspects of ...
Croft, Wayne D.
core
Intracellular Receptor Modulation: Novel Approach to Target GPCRs [PDF]
, 2018 Natalia V. Ortiz Zacarı́as +4 more
openalex +1 more source