Results 181 to 190 of about 61,856 (262)

GPCR-Mediated Cell Intelligence: A Potential Mechanism for Survival and Long-Term Health. [PDF]

Curr Issues Mol Biol
Craig CJ, Boeringer T, Pardo M, Del Pozo A, Maudsley S.   +4 more
europepmc   +1 more source

Coordinated regulation of PIEZO2 by alternative splicing, post‐translational modification, membrane trafficking and protein partners

The Journal of Physiology, EarlyView.
Abstract figure legend Regulatory mechanisms such as alternative splicing, post‐translational modification, membrane trafficking, and protein interactions control channel gating, membrane abundance, and overall activity of PIEZO2. Proper regulation supports PIEZO2‐dependent proprioceptive, somatosensory, nociceptive, pruriceptive and interoceptive ...
Eunice I. Oribamise, Qinglu Li, Mary G. Garry   +2 more
wiley   +1 more source

G Protein-Coupled Receptors in Cerebrovascular Diseases: Signaling Mechanisms and Therapeutic Opportunities. [PDF]

Int J Mol Sci
Gu Q, Yao J, Sheng J, Liu D.
europepmc   +1 more source

Drafting the calmodulation playbook: Emerging structural insights into transient receptor potential channel regulation by calmodulin

The Journal of Physiology, EarlyView.
Abstract figure legend Calmodulin (CaM) is a ubiquitous calcium (Ca2+) sensor that translates intracellular Ca2+ signals into modulation of hundreds of effector proteins including ion channels. CaM is increasingly recognized as a key regulator of the transient receptor potential (TRP) channel family, yet the underlying ‘calmodulation playbook’ is only ...
Aden M. Alemayhu, Candice E. Paulsen
wiley   +1 more source

A Review of the Role and Mechanism of GNG4 Gene Expression in the Tumor Microenvironment Across Broad Spectrum of Tumor Types. [PDF]

Cancer Manag Res
Liu S, Zheng S, Yu X, Xiao M, Sun C, He L.   +5 more
europepmc   +1 more source

Intrinsic pH chemosensitivity of acutely dissociated medullary serotonergic and retrotrapezoid neurones

The Journal of Physiology, EarlyView.
Abstract figure legend Central respiratory chemoreceptors (CRCs) are critical for maintaining normal systemic levels of pH and PCO2. A CRC must respond to pH via intrinsic mechanisms. Here we quantified intrinsic chemosensitivity of medullary 5‐HT neurones and retrotrapezoid nucleus (RTN) neurones using acute dissociation.
Yuanming Wu, Eduardo Bravo, George Bradley Richerson   +2 more
wiley   +1 more source

Dopaminergic neurons are vulnerable to dysregulation of YEATS2-dependent calcium homeostasis. [PDF]

iScience
Lo Piccolo L, Yeewa R, Noisagul P, Monteil A, Shotelersuk V, Jantrapirom S.   +5 more
europepmc   +1 more source

Identification of Crucial Drug Targets and Pathways to Reprogram Drug Resistance Through Epigenetic Modulation in Advanced Lung Cancer Using Integrated Bioinformatics Approach

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Resistance to chemotherapy, which is demonstrated in almost every patient with advanced‐stage lung cancer (ALC), underscores an urgent need to unravel the underlying molecular mechanisms and identify novel strategies to overcome drug resistance. In the present study, an attempt was made to identify epigenetic targets and modulators that can be
Okibur Rahman, Mossammat Rima Akter, Nur Alam   +2 more
wiley   +1 more source

The Mechanism of G Protein-Coupled Receptor Regulation of Ferroptosis in Hepatic Ischemia-Reperfusion Injury. [PDF]

Int J Mol Sci
Hu D, Sun L, Su M, Xing X.
europepmc   +1 more source

Quantifying Heteromer Partitioning Reveals Inflammation‐Dependent Redistribution of Microglial Adenosine A2A and Cannabinoid CB2 Receptors

Glia, Volume 74, Issue 9, September 2026.
Proinflammatory activation reorganizes microglial A2A and CB2 receptors, promoting their incorporation into stable heteromers and blocking agonist‐induced redistribution. The results reveal those heteromers as potential therapeutic targets in inflammatory contexts.
Rafael Franco, Jaume Lillo, Christian Griñán‐Ferré, Mercè Pallàs, Rafael Rivas‐Santisteban   +4 more
wiley   +1 more source