Results 181 to 190 of about 83,092 (356)

Conditional Modeling of GNAO1 Disorder Dissociates Circuit Specific Contributions to Pathology and Rationalizes Ameliorative Strategies

Movement Disorders, EarlyView.
Abstract Background Neurodevelopmental disorders feature various symptoms that frequently include seizures and motor manifestations, but their attribution to disruptions of specific circuits and molecular alterations is notoriously hard to establish, which limits therapeutic interventions.
Gloria Brunori, Stefano Zucca, Colten K. Lankford, Yi‐Zhi Wang, Marianna Franco, Nina A. Alekseeva, Sevinj Ahmedova, Han My Van, Jeffrey N. Savas, Kirill A. Martemyanov   +9 more
wiley   +1 more source

Systematic Meta-Analysis Identifies Co-Expressed Kinases and GPCRs in Ovarian Cancer Tissues Revealing a Potential for Targeted Kinase Inhibitor Delivery [PDF]

, 2019
Hugo Albrecht, Eric Kübler
openalex   +1 more source

Deciphering the soybean root rot pathogen Phytophthora sojae: Signaling pathways, transcriptional regulation, and effector biology

New Plant Protection, EarlyView.
This review highlights how Phytophthora sojae utilizes unconventional lineage‐specific signaling networks, including unique G protein‐coupled receptor fusions, expanded kinases, and rapidly evolving effectors, to infect soybeans. Understanding these divergent molecular paradigms reveals critical vulnerabilities in this destructive pathogen, offering ...
Min Qiu, Xiaoyi Zhang, Bo Yang, Wenwu Ye, Yuanchao Wang   +4 more
wiley   +1 more source

Emerging Agents for Boron Neutron Capture Therapy: Biomolecular Carriers Paving the Way for Precision Radiotherapy

Precision Radiation Oncology, EarlyView.
Boron neutron capture therapy (BNCT) requires key non‐negotiable technical criteria: megadose administration, precise tumor‐specific targeting, favorable biocompatibility, and sustained tumor retention. Overcoming these interconnected challenges fundamentally depends on biomolecular carriers, which are critical for translating the therapeutic potential
Chang Chen, Maosong Yang, Jiheng Wang, Ling Zhang, Shaobo Huang, Xiao Xu, Yang Liu   +6 more
wiley   +1 more source

Evolutionary Conservation of a GPCR-Independent Mechanism of Trimeric G Protein Activation [PDF]

, 2015
Brantley Coleman, Arthur Marivin, Kshitij Parag‐Sharma, Vincent DiGiacomo, Seongseop Kim, Judy S Pepper, Jason C. Casler, Lien T. Nguyen, Michael R. Koelle, Mikel Garcia‐Marcos   +9 more
openalex   +1 more source

The Hydrophobic Ligands Entry and Exit from the GPCR Binding Site-SMD and SuMD Simulations [PDF]

, 2020
Jakub Jakowiecki, Urszula Orzeł, Sathapana Chawananon, Przemysław Miszta, Sławomir Filipek   +4 more
openalex   +1 more source

Resolving GPCR bias [PDF]

Nature Chemical Biology, 2022
openaire   +2 more sources

The evolving role of regulatory T cells in Sjögren's disease pathogenesis and the promise of Treg‐based therapies: A comprehensive review

Rheumatology &Autoimmunity, EarlyView.
Graphical Abstract The evolving role of regulatory T cells in primary Sjögren's disease pathogenesis and the promise of Treg‐based therapies. Abstract Sjögren's disease (SjD) is a chronic systemic autoimmune disorder characterised by exocrine gland dysfunction and diverse systemic manifestations.
Gagan Urs, Bharath Raj Srinivasan, Himabindu Jayaprakash Narayan, Mirunalini Gobinath, Lekitha Manjunath, Mahabaleshwar Mamadapur   +5 more
wiley   +1 more source

G protein-coupled receptor autoantibody expression patterns in adults with decelerated biological aging mirror pediatric profiles. [PDF]

BMC Immunol
Paniskaki K, Stervbo U, Goretzki S, Hufnagel D, Anft M, Heidecke H, Westhoff TH, Rohn H, Felderhoff-Mueser U, Witzke O, Dohna-Schwake C, Babel N.   +11 more
europepmc   +1 more source

The systematic annotation of the three main GPCR families in Reactome [PDF]

, 2010
Bijay Jassal, S Jupe, Michael Caudy, Ewan Birney, Lincoln Stein, Henning Hermjakob, Peter D’Eustachio   +6 more
openalex   +1 more source