Results 201 to 210 of about 112,572 (285)

Conformational biosensors delineate endosomal G protein regulation by GPCRs. [PDF]

Nat Commun
Wysolmerski B, Fisher NM, Dates AN, Inoue A, Blythe EE, von Zastrow M.   +5 more
europepmc   +1 more source

Spatiotemporal dynamics of β‐arrestin‐mediated Src activation in 5‐HT7 receptor signaling pathway

The FEBS Journal, EarlyView.
GPCRs induce distinct cellular responses via G protein‐ or β‐arrestin‐mediated signaling pathways. This study revealed that β‐arrestin‐biased 5‐HT7R ligand induces slow, sustained Src activation, contrasting with transient G protein‐mediated activation.
Hyunbin Kim, Yong Woo Lee, Huimin Lee, Eunseo Park, Jieon Lee, Hae Nim Lee, Kyeong‐Man Kim, Hyunah Choo, Jihye Seong   +8 more
wiley   +1 more source

<i>In Vitro</i> Evolution of the Adenosine A_2A Receptor Based on an Antagonist Binding Using a Ribosome Display. [PDF]

J Am Chem Soc
Fukasawa G, Matsuoka Y, Tran DP, Nishigaki H, Fukunaga K, Watanabe T, Doura T, Terasaka N, Kagawa A, Murata T, Kitao A, Kiyonaka S, Matsuura T.   +12 more
europepmc   +1 more source

ALOX15 mediates thrombin‐induced myristoylation, trafficking, and interaction of protease‐activated receptors, leading to platelet activation and hemostasis

The FEBS Journal, EarlyView.
The role of PARs in platelet function is fairly known; however, the underlying mechanisms are not fully understood. We report that thrombin myristoylates PAR4 in mouse platelets and PAR1 and PAR4 in human platelets, facilitating their membrane transport and interaction, leading to PAR3/4 heterodimers in mice and PAR1/4 heterodimers in humans.
Suresh Govatati, Chandra Sekhar Yadavalli, Md Monirul Hoque, Swapna Thota, Gadiparthi N. Rao   +4 more
wiley   +1 more source

Re-evaluating Gα protein-response element specificity in GPCR signaling. [PDF]

Commun Biol
Saito A, Kise R, Yamaguchi S, Yanagawa M, Inoue A.   +4 more
europepmc   +1 more source

Proteolytic degradation of regulator of G protein signaling 2 facilitates temporal regulation of Gq/11 signaling and vascular contraction [PDF]

, 2011
Kanai, Stanley M., Edwards, Alethia J., Rurik, Joel G., Osei-Owusu, Patrick, Blumer, Kendall J.   +4 more
core   +1 more source

GPCR-SAS

G protein-coupled receptors (GPCRs) are one of the largest protein families in mammals. They mediate signal transduction across cell membranes and are important targets for the pharmaceutical industry. The G Protein-Coupled Receptors-Sequence Analysis and Statistics (GPCR-SAS) web application provides a set of tools to perform comparative analysis of ...
Gómez-Tamayo, José Carlos||, Olivella, Mireia||, Ríos, Santiago, Hoogstraat, Marlous, Gonzalez, Angel||, Mayol, Eduardo||, Deupi, Xavier||, Campillo Grau, María Mercedes||, Cordomí Montoya, Arnau||   +8 more
openaire   +1 more source

Mapping malignant T‐cell states and immune circuits in Sézary syndrome by single‐cell analysis

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Peripheral blood single‐cell RNA‐seq from leukaemic CTCL defined three malignant T‐cell programmes: MTC CM, MTC Reg and MTC E/EM, each with distinct features and candidate vulnerabilities. For example, inferred immune circuits highlighted actionable IL‐10/JAK–TYK2–STAT3 signalling, KIR–MHC I inhibitory interactions and myeloid/B‐cell inflammatory and ...
Beth A. Childs, Eslam A. Elghonaimy, Praveen Ramakrishnan Geethakumari, Kiran A. Kumar, Joseph F. Merola, Heather W. Goff, Todd A. Aguilera   +6 more
wiley   +1 more source

A Multifunctional β‐Defensin‐3 Mimetic Peptide Modulates Host–Biofilm Interactions and Reduces Bone Loss in Periodontitis

Journal of Periodontal Research, EarlyView.
BDMP, a peptide that can penetrate cells and tissues, offering antimicrobial and anti‐inflammatory effects, has been identified as a potential new therapy for periodontitis. ABSTRACT Aim This study evaluated the potential of a beta‐defensin‐3 mimetic peptide (BDMP), a synthetic cell‐penetrating peptide with antimicrobial and immunomodulatory properties,
Beom Soo Jo, Dong Woo Lee, Ji‐Young Lee, Sanghui Seok, Yu‐Bin Kim, Jue‐Yeon Lee, Shin‐Young Park, Young Dan Cho, Yang Jo Seol, Yoon Shin Park, Shahram Ghanaati, Homayoun H. Zadeh, Chong Pyung Chung, Yoon Jeong Park   +13 more
wiley   +1 more source

A Transferable and Robust Computational Framework for Class A GPCR Activation Free Energies. [PDF]

J Phys Chem Lett
Aureli S, Piasentin N, Fröhlking T, Rizzi V, Gervasio FL.   +4 more
europepmc   +1 more source