The Use of Biologics for Targeting GPCRs in Metastatic Cancers [PDF]
Cian McBrien, David O’Connell
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Evaluating Cellular Impedance Assays for Detection of GPCR Pleiotropic Signaling and Functional Selectivity [PDF]
, 2009 Matthew F. Peters, Clay W. Scott
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Non‐canonical PKG1 regulation in cardiovascular health and disease
British Journal of Pharmacology, EarlyView.It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley +1 more source
GPCR systems coordinate cellular resilience against aging-associated stress. [PDF]
Front Mol BiosciBoeringer T +6 more
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Structure of a lasso peptide bound ETB receptor provides insights into the mechanism of GPCR inverse agonism [PDF]
Wataru Shihoya +12 more
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Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?
British Journal of Pharmacology, EarlyView.Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli +7 more
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Recent Advances in GPCR Ligand Discovery Using DNA-Encoded Library Technology: From Affinity Binding to Functional Bias and Allosteric Modulation. [PDF]
ACS Med Chem LettZhou R, Wang J, Li X, An Y.
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The potential for biased signalling in the P2Y receptor family of GPCRs
British Journal of Pharmacology, EarlyView.The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk +2 more
wiley +1 more source
The GPCR Connection: Linking Alzheimer's Disease and Glioblastoma. [PDF]
J Cell Mol MedCaniceiro AB +4 more
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Function-Related Conformational Dynamics of GPCRs Revealed by Solution NMR
, 2022 Takumi Ueda +5 more
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