Results 221 to 230 of about 83,092 (356)

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Host GPCR-cAMP signaling balances Gαs and Gαi activity to control intracellular <i>Brucella</i> infection. [PDF]

mBio
Kang Y-S, Kirby JE.
europepmc   +1 more source

Confrontational Dynamics of a GPCR Revealed by Single Molecule FRET [PDF]

, 2015
Reza Vafabakhsh, Joshua Levitz, Ehud Y. Isacoff   +2 more
openalex   +1 more source

Reshaping the Yeast Galactose Regulon via GPCR Signaling Cascade

, 2023
Cong Fan, Jifeng Yuan
openalex   +1 more source

5‐HT2A receptor agonism by tert‐leucinamide and valinamide synthetic cannabinoids: In vitro and in vivo evidence

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose New synthetic cannabinoid receptor agonists (SCRAs) are associated with severe adverse effects, including unexpected psychiatric symptoms. These compounds are mainly active through their potent agonism on the cannabinoid receptors CB1 and CB2.
Giorgia Corli, Deborah Rudin, Dino Luethi, Matthias E. Liechti, Sabrine Bilel, Matteo Marti, Henrik Green, Manuela Carla Monti, Caitlyn Norman   +8 more
wiley   +1 more source

A negative survival pressure selection system enables GPCR antagonist screening. [PDF]

Cell Discov
Xu T, Sun Q, Zhang S, Liu T, Sun X, Wang X, Lin B, Liu Z, Wang J, He G, Liu X.   +10 more
europepmc   +1 more source

Real-time visualization of ligand-specific conformational dynamics of GPCR C-terminal domain in living cells [PDF]

Zhao Lin, Xinyao Chen, Lijuan Ma, Hang Fu, Hao Wang, Kai Yang, Zijian Li, Fangfu Ye, Ying Lü, Shuxin Hu, Xiaogang Li   +10 more
openalex   +1 more source

Joint Public Review: Large-scale deorphanization of Nematostella vectensis neuropeptide GPCRs supports the independent expansion of bilaterian and cnidarian peptidergic systems

, 2023
Daniel Thiel, Luis Alfonso Yáñez-Guerra, Amanda Kieswetter, Alison G. Cole, Liesbet Temmerman, Ulrich Technau, Gáspár Jékely   +6 more
openalex   +1 more source

Drugs that act on both G protein‐coupled receptors (GPCRs) and kinases: potentiation of effects, side effects and general aspects of drug pleiotropy

British Journal of Pharmacology, EarlyView.
Abstract Background A drug designed for a specific target often interacts with multiple targets, either unintentionally or as part of its intended mechanism of action. This has been called pharmacological pleiotropy or polypharmacology. There are key endogenous ligands such as ATP, GABA and glutamate that act on various proteins in humans. Furthermore,
Hampus Ljunggren, Aleksandr Sokolov, Flavio Ballante, Robert Fredriksson, Francisco Lagunas‐Rangel, Alexander S. Hauser, Stefan Knapp, Jörgen Jonsson, Helgi B. Schiöth   +8 more
wiley   +1 more source

Novel roles of GPCRs in the renal collecting duct. [PDF]

Physiology (Bethesda)
Kui MK, Zhang JJ, Pluznick JL.
europepmc   +1 more source