Synthesis and biological evaluation of new bivalent GPCR ligands
, 2018 Mingcheng Qian
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GPCR Agonist Mechanisms: From Structural Dynamics to Targeted Drug Discovery
pharmacology science
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The ELABELA GPCR ligand: a smORF hidden in plain sight
, 2015 Christopher Southan
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RASD2 Drives Renal Clear Cell Carcinoma Progression via RAF1 (Ser338) Phosphorylation
Cancer Science, EarlyView.RASD2 drives clear cell renal cell carcinoma (ccRCC) progression by physically interacting with RAF1 to induce its Ser338 phosphorylation, which subsequently activates the P38/ERK–MAPK signaling pathway to promote malignant tumor phenotypes and poor prognosis.
Jingxuan Yu +10 more
wiley +1 more source
Gintonin as a Lysophosphatidic Acid-Enriched GPCR Ligand System: Molecular Architecture and Receptor Pharmacology in <i>Panax ginseng</i>. [PDF]
BiomoleculesKim KH, Yoo BC.
europepmc +1 more source
The UFSP2-C1orf27 complex positions nascent GPCRs to the ufmylation system for ER export control. [PDF]
iScienceXu X +5 more
europepmc +1 more source
Human GPCR Interactome and Investigation of the KCTD/beta2-adrenergic Receptor Interactions
, 2014 Ekaterina Sokolina
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Unexpected Promotion of Bone Regeneration by Inhibition of BMPR1A‐Mediated BMP Signalling
Cell Proliferation, EarlyView.BMPR1A downregulation reduces ID1, releases TCF3 to activate GNG4‐PI3K‐AKT signalling, thereby promoting OPC proliferation and bone regeneration. ABSTRACT Bone morphogenetic protein (BMP) signalling plays a pivotal role in bone regeneration by regulating osteoprogenitor cell (OPC) function, and BMPs have been widely used in clinical treatment. However,
Zihao Zhou +8 more
wiley +1 more source
Spent Coffee Ground Extracts: A Sustainable Source of Antioxidant and Immunomodulatory Bioactives for Managing Lifestyle-Related Chronic Diseases. [PDF]
Int J Mol SciHasna A +10 more
europepmc +1 more source