Phytochemicals in Food and Medicine, Volume 1, Issue 2, June 2026.This outlines the progress for developing a sleep‐modulating herbal formula (SMF). It begins with the identification of effective compounds and quality control, then uses network pharmacology and molecular docking to explain the mechanisms behind the observation found on the behavioural and neurobiological results in animal study.
Jasmine U. Ting +7 more
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Constitutive activity among orphan G protein-coupled receptors: Molecular mechanisms and pharmacological perspectives. [PDF]
Mol PharmacolMurphy RE, Smith HR, Allen JA.
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Pharmacologic MRI Brain Imaging Studies of Serotonin 5‐HT1 Receptor Agonists in Awake Mice
Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.ABSTRACT Serotonin (5‐hydroxytryptamine, 5‐HT) type‐1 G protein‐coupled receptors are expressed throughout the central nervous system. 5‐HT1AR activation is the putative mechanism of approved drugs for generalized anxiety disorder and major depressive disorder and is being studied in the treatment of autism and neurological disorders.
Brittany M. Brems +5 more
wiley +1 more source
Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.ABSTRACT Rush Medical College implemented a new, integrated pre‐clerkship curriculum. Pharmacology was integrated with other basic sciences into a flipped, small‐group, case‐based structure. This report describes the main features of the pharmacology curriculum for pharmacology directors to have a template.
Brinda Desai Bradaric +3 more
wiley +1 more source
A heteromeric TRP channel that functions as a WNT-activated G protein-coupled receptor. [PDF]
Nat CommunHardy EP +10 more
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Protein design and RNA design: Perspectives
Quantitative Biology, Volume 14, Issue 2, June 2026.Abstract Advances in deep learning and generative modeling have transformed the landscape of protein and RNA design, enabling rapid and precise creation of novel biomolecules with tailored structures and functions. In protein design, generative deep learning frameworks now support backbone generation, sequence optimization, and joint sequence–structure
Xi Chen, Xu Dai, Peilong Lu
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Effect of Ropivacain and Bupivacain on Calcium-Related and G-Protein Coupled Processes in PMNs: A Human In-Vitro Study. [PDF]
Health Sci RepKraus RF, Galla T, Gruber M, Wittmann S.
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GRKs and arrestins: Nomenclature and functions in GPCR‐dependent and ‐independent signalling
British Journal of Pharmacology, Volume 183, Issue 11, Page 2619-2633, June 2026.G protein‐coupled receptor (GPCR) kinases (GRKs) and arrestins play a critical role in the regulation of GPCR signalling. Historic names of mammalian GRKs were replaced by systematic ones in the 1990s; however, both kinds of names are currently in use for mammalian arrestins.
Vsevolod V. Gurevich
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Allosteric activation of the glutamate receptor mGlu2 by the serotonin receptor 5-HT<sub>2A</sub>. [PDF]
Nat CommunGai S +13 more
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Boron Neutron Capture Therapy at a Crossroads: Translational Gap and Emerging Delivery Agents
Chemistry – A European Journal, Volume 32, Issue 17, 5 May 2026.This review surveys recent advances in boron delivery agents for BNCT, emphasizing the shift from classical small molecules to multifunctional nanocarriers and theranostic systems. By integrating targeting, imaging, and therapy, next‐generation boron compounds aim to bridge the gap between (bio)chemical innovation and clinical translation.
Christoph Selg, Evamarie Hey‐Hawkins
wiley +1 more source