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Nanobody-drug conjugates for targeting specific GPCR pairs. [PDF]
PLoS BiolHuang X, Roth BL.
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Functional significance of opioid receptor homomers and heteromers. [PDF]
Nat CommunFerré S, Ciruela F, Pardo L.
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Dissociation kinetics of G proteins from G protein-coupled receptors and effects of allosteric modulation. [PDF]
Proc Natl Acad Sci U S AWang J +9 more
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SAR-Guided Scaffold Innovation of Selective V<sub>2</sub>R Antagonists: Therapeutic Frontiers in ADPKD. [PDF]
ACS Med Chem LettShi H, Li Y, Liang SH.
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PIONEER: A periplasmic display platform for synthetic biology-based screening of genetically encoded protein regulators. [PDF]
J Biol ChemRowe JB, Lee K, Isom DG.
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Prompt-based multimodal representation learning for drug repurposing. [PDF]
Brief BioinformLiu J +10 more
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Life Sciences, 2003
The concept that GPCRs exist and potentially function as dimers and/or higher oligomers has progressed recently from hypothesis to being widely accepted. A range of techniques has contributed to this understanding, including co-immunoprecipitation and various forms of fluorescence and bioluminescence resonance energy transfer.
Graeme, Milligan +3 more
openaire +2 more sources
The concept that GPCRs exist and potentially function as dimers and/or higher oligomers has progressed recently from hypothesis to being widely accepted. A range of techniques has contributed to this understanding, including co-immunoprecipitation and various forms of fluorescence and bioluminescence resonance energy transfer.
Graeme, Milligan +3 more
openaire +2 more sources
2007
Many GPCR models have been built over the years for many different purposes, of which drug-design undoubtedly has been the most frequent one. The release of the structure of bovine rhodopsin in August 2000 enabled us to analyze models built before that period to learn things for the models we build today.
Paiva, A.C. +4 more
openaire +3 more sources
Many GPCR models have been built over the years for many different purposes, of which drug-design undoubtedly has been the most frequent one. The release of the structure of bovine rhodopsin in August 2000 enabled us to analyze models built before that period to learn things for the models we build today.
Paiva, A.C. +4 more
openaire +3 more sources