Differences in the signaling pathways of α1A- and α1B-adrenoceptors are related to different endosomal targeting [PDF]
, 2013 Aims: To compare the constitutive and agonist-dependent endosomal trafficking of α1A- and α1B-adrenoceptors (ARs) and to establish if the internalization pattern determines the signaling pathways of each subtype.
A Hirasawa +54 more
core +15 more sources
Frontiers in Pharmacology, 2023 Certain 4-substituted analogs of 1-(2,5-dimethoxyphenyl)isopropylamine (2,5-DMA) are psychoactive classical hallucinogens or serotonergic psychedelic agents that function as human 5-HT2A (h5-HT2A) serotonin receptor agonists.
Prithvi Hemanth +5 more
doaj +1 more source
TLRs as a Promise Target Along With Immune Checkpoint Against Gastric Cancer
Frontiers in Cell and Developmental Biology, 2021 Gastric cancer (GC) is one of the most common cancers in the world, and the incidence of gastric cancer in Asia appears to increase in recent years. Although there is a lot of improvement in treatment approaches, the prognosis of GC is poor.
Lin Cui, Xiuqing Wang, Dekai Zhang
doaj +1 more source
Predicting GPR40 Agonists with A Deep Learning‐Based Ensemble Model
ChemistryOpen, 2023 Recent studies have identified G protein‐coupled receptor 40 (GPR40) as a promising target for treating type 2 diabetes mellitus, and GPR40 agonists have several superior effects over other hypoglycemic drugs, including cardiovascular protection and ...
Jiamin Yang +4 more
doaj +1 more source
Conductance increases produced by bath application of cholinergic agonists to Electrophorus electroplaques [PDF]
, 1975 When solutions containing agonists are applied to the innervated face of an Electrophorus electroplaque, the membrane's conductance increases. The agonist-induced conductance is increased at more negative membrane potentials.
Changeux, Jean-Pierre +2 more
core +7 more sources
The relationship between anti-mullerian hormone and ovarian response and fertility outcome in infertile women undergoing assisted reproductive techniques (ART) and IUI [PDF]
Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān, 2023 Introduction: Anti-Mullerian Hormone (AMH) is related to woman's age, the number of antral follicles, and the outcome of assisted reproductive techniques.
Fariba Seyedoshohadaei +3 more
doaj +1 more source
eLife, 2021 Ligand binding stabilizes different G protein-coupled receptor states via a complex allosteric process that is not completely understood. Here, we have derived free energy landscapes describing activation of the β2 adrenergic receptor bound to ligands ...
Oliver Fleetwood +2 more
doaj +1 more source
Doubles-agonistes, tri-agonistes et multi-agonistes incrétines/glucagon
Médecine des Maladies Métaboliques, 2021 Resume L’innovation pharmacologique en diabetologie est un veritable defi. La nouvelle famille des co-agonistes des recepteurs GIP/GLP-1 represente une avancee therapeutique importante pour ameliorer la prise en charge du diabete de type 2 (DT2). L’activation des deux recepteurs incretines peut avoir des effets metaboliques additifs en comparaison a ...
Phan, Franck, Andreelli, Fabrizio
openaire +2 more sources
Receptor modulators associated with the hypothalamus -pituitary-thyroid axis
Frontiers in Pharmacology, 2023 The hypothalamus-pituitary-thyroid (HPT) axis maintains normal metabolic balance and homeostasis in the human body through positive and negative feedback regulation.
Xianbin Cheng +7 more
doaj +1 more source
Functional Stoichiometry at the Nicotinic Receptor. The Photon Cross Section for Phase 1 Corresponds to Two Bis-Q Molecules per Channel [PDF]
, 1982 These experiments examine changes in the agonist-induced conductance that occur when the agonist-receptor complex is perturbed. Voltage-clamped Electrophorus electroplaques are exposed to the photoisomerizable agonist trans-Bis-Q A 1-µs laser flash ...
Lester, Henry A., Sheridan, Robert E.
core +1 more source