Frontiers in Pharmacology, 2023 Certain 4-substituted analogs of 1-(2,5-dimethoxyphenyl)isopropylamine (2,5-DMA) are psychoactive classical hallucinogens or serotonergic psychedelic agents that function as human 5-HT2A (h5-HT2A) serotonin receptor agonists.
Prithvi Hemanth +5 more
doaj +1 more source
TLRs as a Promise Target Along With Immune Checkpoint Against Gastric Cancer
Frontiers in Cell and Developmental Biology, 2021 Gastric cancer (GC) is one of the most common cancers in the world, and the incidence of gastric cancer in Asia appears to increase in recent years. Although there is a lot of improvement in treatment approaches, the prognosis of GC is poor.
Lin Cui, Xiuqing Wang, Dekai Zhang
doaj +1 more source
Predicting GPR40 Agonists with A Deep Learning‐Based Ensemble Model
ChemistryOpen, 2023 Recent studies have identified G protein‐coupled receptor 40 (GPR40) as a promising target for treating type 2 diabetes mellitus, and GPR40 agonists have several superior effects over other hypoglycemic drugs, including cardiovascular protection and ...
Jiamin Yang +4 more
doaj +1 more source
The relationship between anti-mullerian hormone and ovarian response and fertility outcome in infertile women undergoing assisted reproductive techniques (ART) and IUI [PDF]
Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān, 2023 Introduction: Anti-Mullerian Hormone (AMH) is related to woman's age, the number of antral follicles, and the outcome of assisted reproductive techniques.
Fariba Seyedoshohadaei +3 more
doaj +1 more source
, 2020 Binding of muscarinic ligands, both antagonists and agonists, and their effects on the conformation of the M2 acetylcholine receptor were modeled in silico and compared to experimental data.
Alena Randáková +11 more
core +2 more sources
eLife, 2021 Ligand binding stabilizes different G protein-coupled receptor states via a complex allosteric process that is not completely understood. Here, we have derived free energy landscapes describing activation of the β2 adrenergic receptor bound to ligands ...
Oliver Fleetwood +2 more
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Receptor modulators associated with the hypothalamus -pituitary-thyroid axis
Frontiers in Pharmacology, 2023 The hypothalamus-pituitary-thyroid (HPT) axis maintains normal metabolic balance and homeostasis in the human body through positive and negative feedback regulation.
Xianbin Cheng +7 more
doaj +1 more source
Long-acting beta(2)-agonist in addition to tiotropium versus either tiotropium or long-acting beta(2)-agonist alone for chronic obstructive pulmonary disease [PDF]
, 2012 BackgroundLong-acting bronchodilators comprising long-acting beta(2)-agonists and the anticholinergic agent tiotropium are commonly used for managing persistent symptoms of chronic obstructive pulmonary disease.
Christopher J Cates +3 more
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Characterization of TR‐107, a novel chemical activator of the human mitochondrial protease ClpP
Pharmacology Research & Perspectives, 2022 We recently described the identification of a new class of small‐molecule activators of the mitochondrial protease ClpP. These compounds synthesized by Madera Therapeutics showed increased potency of cancer growth inhibition over the related compound ...
Emily M. J. Fennell +16 more
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Differential β-arrestin2 requirements for constitutive and agonist-induced internalization of the CB1 cannabinoid receptor [PDF]
, 2013 CB1 cannabinoid receptor (CB1R) undergoes both constitutive and agonist-induced internalization, but the underlying mechanisms of these processes and the role of beta-arrestins in the regulation of CB1R function are not completely understood.
Boros, Eszter +7 more
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