Results 31 to 40 of about 588,311 (310)

Reconciling intrinsic properties of activating TNF receptors by native ligands versus synthetic agonists

Frontiers in Immunology, 2023
The extracellular domain of tumor necrosis factor receptors (TNFR) generally require assembly into a homotrimeric quaternary structure as a prerequisite for initiation of signaling via the cytoplasmic domains.
George Fromm, Suresh de Silva, Taylor H. Schreiber   +2 more
doaj   +1 more source

Holding chambers (spacers) versus nebulisers for beta-agonist treatment of acute asthma [PDF]

, 2006
In acute asthma inhaled beta 2-agonists are often administered to relieve bronchospasm by wet nebulisation, but some have argued that metered-dose inhalers with a holding chamber (spacer) can be equally effective.
Christopher J Cates, Jacqueline A Crilly, Brian H Rowe, Crilly, JA, Rowe, BH, Cates, CJ   +5 more
core   +1 more source

In Vitro and In Silico Characterization of G-Protein Coupled Receptor (GPCR) Targets of Phlorofucofuroeckol-A and Dieckol

Marine Drugs, 2021
Phlorotannins are polyphenolic compounds in marine alga, especially the brown algae. Among numerous phlorotannins, dieckol and phlorofucofuroeckol-A (PFF-A) are the major ones and despite a wider biological activity profile, knowledge of the G protein ...
Pradeep Paudel, Su Hui Seong, Se Eun Park, Jong Hoon Ryu, Hyun Ah Jung, Jae Sue Choi   +5 more
doaj   +1 more source

Holding chambers (spacers) versus nebulisers for beta-agonist treatment of acute asthma [PDF]

, 2013
Background In acute asthma inhaled beta₂-agonists are often administered by nebuliser to relieve bronchospasm, but some have argued that metered-dose inhalers with a holding chamber (spacer) can be equally effective.
Welsh, EJ, Rowe, BH, Cates, CJ
core   +1 more source

Identification of Two Novel α1-AR Agonists Using a High-Throughput Screening Model

Molecules, 2014
α1-Adrenoceptors (ARs; 1A, 1B, and 1D) have been determined to perform different prominent functions in the physiological responses of the sympathetic nervous system.
Fang Xu, Hong Chen, Xuelan He, Jingyi Xu, Bingbing Xu, Biyun Huang, Xue Liang, Mu Yuan   +7 more
doaj   +1 more source

Motor activity following the administration of selective D-1 and D-2 dopaminergic drugs to MPTP-treated common marmosets [PDF]

, 1992
The ability of selective D-1 agonist and antagonist drugs to alter motor deficits and locomotor activity was studied in MPTP-treated common marmosets.
Smith, L. A., Jähnig, P., Marsden, C. D., Jenner, P., Lange, Klaus W., Löschmann, P. A.   +5 more
core   +1 more source

An Enantiomer of an Oral Small Molecule TSH Receptor Agonist Exhibits Improved Pharmacologic Properties

Frontiers in Endocrinology, 2016
We are developing an orally available small molecule, allosteric TSH receptor (TSHR) agonist for follow up diagnostics of patients with thyroid cancer.
Susanne Neumann, Umesh Padia, Mary Jane Cullen, Elena Eliseeva, Eshel A Nir, Robert F Place, Sarah J Morgan, Marvin C Gershengorn   +7 more
doaj   +1 more source

Combination inhaled steroid and long-acting beta-agonist in addition to tiotropium versus tiotropium or combination alone for chronic obstructive pulmonary disease (Review) [PDF]

, 2011
Background The long-acting bronchodilator tiotropium and single inhaler combination therapy of inhaled corticosteroids and long-acting beta(2)-agonists are both commonly used for maintenance treatment of chronic obstructive pulmonary disease.
Christopher J Cates, Karner, C, Cates, CJ, Charlotta Karner   +3 more
core   +1 more source

6-Bromohypaphorine from Marine Nudibranch Mollusk Hermissenda crassicornis is an Agonist of Human α7 Nicotinic Acetylcholine Receptor

Marine Drugs, 2015
6-Bromohypaphorine (6-BHP) has been isolated from the marine sponges Pachymatisma johnstoni, Aplysina sp., and the tunicate Aplidium conicum, but data on its biological activity were not available.
Igor E. Kasheverov, Irina V. Shelukhina, Denis S. Kudryavtsev, Tatyana N. Makarieva, Ekaterina N. Spirova, Alla G. Guzii, Valentin A. Stonik, Victor I. Tsetlin   +7 more
doaj   +1 more source

The NMDA agonist D-cycloserine facilitates fear memory consolidation in humans [PDF]

, 2009
Animal research suggests that the consolidation of fear and extinction memories depends on N-methyl D-aspartate (NMDA)- type glutamate receptors.
Dolan, RJ, Holt, Beatrice, Holt, B., Kalisch, R, Büchel, C, Martino, Benedetto de, Büchel, Christian, Dolan, R. ; https://orcid.org/, Kalisch, R., Büchel, C., Holt, B, Klöppel, Stefan, Dolan, R.J., Petrovic, P,, Petrovic, P., Petrovic, Predrag, De Martino, B., Klöppel, S., Dolan, Raymond J., De, Martino B, Kalisch, Raffael, Klöppel, S   +21 more
core   +1 more source