Results 31 to 40 of about 766,676 (298)

Quinolones modulate ghrelin receptor signaling: potential for a novel small molecule scaffold in the treatment of cachexia [PDF]

, 2018
Cachexia is a metabolic wasting disorder characterized by progressive weight loss, muscle atrophy, fatigue, weakness, and appetite loss. Cachexia is associated with almost all major chronic illnesses including cancer, heart failure, obstructive ...
Cano, Rafael, Juan Rodríguez, Rocío, Kandil, Dalia, McGlacken, Gerard P., Pastor Cavada, Elena, Schellekens, Harriët, Shaban, Hamdy, Shanahan, Rachel, Torres-Fuentes, Cristina   +8 more
core   +3 more sources

6-Bromohypaphorine from Marine Nudibranch Mollusk Hermissenda crassicornis is an Agonist of Human α7 Nicotinic Acetylcholine Receptor

Marine Drugs, 2015
6-Bromohypaphorine (6-BHP) has been isolated from the marine sponges Pachymatisma johnstoni, Aplysina sp., and the tunicate Aplidium conicum, but data on its biological activity were not available.
Igor E. Kasheverov, Irina V. Shelukhina, Denis S. Kudryavtsev, Tatyana N. Makarieva, Ekaterina N. Spirova, Alla G. Guzii, Valentin A. Stonik, Victor I. Tsetlin   +7 more
doaj   +1 more source

A simple open source bioinformatic methodology for initial exploration of GPCR ligands’ agonistic/antagonistic properties

Pharmacology Research & Perspectives, 2020
Drug development is an arduous procedure, necessitating testing the interaction of a large number of potential candidates with potential interacting (macro)molecules.
Athanasios A. Panagiotopoulos, Christina Papachristofi, Konstantina Kalyvianaki, Panagiotis Malamos, Panayiotis A. Theodoropoulos, George Notas, Theodora Calogeropoulou, Elias Castanas, Marilena Kampa   +8 more
doaj   +1 more source

Enhanced self-administration of the CB1 receptor agonist WIN55,212-2 in olfactory bulbectomized rats: evaluation of possible serotonergic and dopaminergic underlying mechanisms [PDF]

, 2014
Depression has been associated with drug consumption, including heavy or problematic cannabis use. According to an animal model of depression and substance use disorder comorbidity, we combined the olfactory bulbectomy (OBX) model of depression with ...
Amchova P, Babinska Z, Dusek L, FADDA, PAOLA, Fattore L., FRATTA, WALTER, Giugliano V, Kucerova J, Micale V, SCHERMA, MARIA, Sulcova A, ZANDA, MARY TRESA   +11 more
core   +1 more source

Impact of dextroamphetamine substitution on the use of illicit amphetamines in adults with amphetamine dependence: a study protocol for the multicentre double blind randomised controlled trial ATLAS4Dependence

BMJ Open
Introduction There is limited evidence on how to effectively treat individuals from marginalised populations with dependence on amphetamine and/or methamphetamine (collectively referred to hereafter as amphetamine dependence).
, Jörg Assmus, Kjell Arne Johansson, Nicholas Lintzeris, Fatemeh Chalabianloo, Anne Halmøy, Lars T Fadnes, Nadine Ezard, Brendan Clifford, John Fredrik Askjer, Olav Spigset, Torgeir Gilje Lid, Jon Mordal, Else-Marie Løberg, Christina Dahl Andersen, Jan Tore Daltveit, Aleksander H Erga, Kristin K Solli, Minna A K Hansen, Christian Ohldieck, Christer F Aas, Trond Aamo, Tine B Edvardsdal, Siv-Elin L Carlsen, Prayash Chaudhary, Marianne Cook Pierron, Gry I Dale, Silvana De Pirro, Karl Trygve Druckrey-Fiskaan, Zhanna Gaulen, Beate H Trettenes, Minna AK Hansen, Mette H Nordbotn, Line Holtan, Arild Knutsen, Kristin K Solli, Heidi F Kristiansen, Svanhild Mellingen, Maria K Olsvold, Solveig IS Reinertsen, Kristin Sannerud, Krista Siefried, Bente Sikveland, Morten Sommerbakk, Herman Steffensen, Jørn H Vold   +45 more
doaj   +1 more source

Models of self-peptide sampling by developing T cells identify candidate mechanisms of thymic selection [PDF]

, 2013
Conventional and regulatory T cells develop in the thymus where they are exposed to samples of self-peptide MHC (pMHC) ligands. This probabilistic process selects for cells within a range of responsiveness that allows the detection of foreign antigen ...
Bains, Iren, Seddon, Benedict, van Santen, Hisse M., Yates, Andrew J.   +3 more
core   +1 more source

Namodenoson at the Crossroad of Metabolic Dysfunction-Associated Steatohepatitis and Hepatocellular Carcinoma

Biomedicines
Namodenoson (CF102) is a small, orally available, anti-inflammatory, and anti-cancer drug candidate currently in phase 2B trial for the treatment of metabolic dysfunction-associated steatohepatitis (MASH; formerly known as non-alcoholic steatohepatitis ...
Ohad Etzion, Avital Bareket-Samish, David Yardeni, Pnina Fishman   +3 more
doaj   +1 more source

Predicted Structures and Dynamics for Agonists and Antagonists Bound to Serotonin 5-HT2B and 5-HT2C Receptors [PDF]

, 2011
Subtype 2 serotonin (5-hydroxytryptamine, 5-HT) receptors are major drug targets for schizophrenia, feeding disorders, perception, depression, migraines, hypertension, anxiety, hallucinogens, and gastrointestinal dysfunctions.' We report here ...
Abrol, Ravinder, Goddard, William A., III, Heo, Jiyoung, Kim, Soo-Kyung, Li, Youyong   +4 more
core   +2 more sources

Improvement of irritable bowel syndrome with glucagon like peptide-1 receptor agonists: a systematic review and meta-analysis

Frontiers in Endocrinology
IntroductionIrritable bowel syndrome (IBS) is a severe gastrointestinal condition with symptoms like pain, bloating, diarrhea, and constipation. Glucagon-like peptide-1 (GLP-1) receptors, expressed in the central nervous system and peripheral tissues ...
Mohamed E. A. Mostafa, Tariq Alrasheed
doaj   +1 more source

Potential Adiponectin Receptor Response Modifier Therapeutics

Frontiers in Endocrinology, 2019
Many human diseases may benefit from adiponectin replacement therapy, but due to pharmacological disadvantages of the intact protein, druggable options focus on peptidic, and small molecule agonists of the adiponectin receptor.
Laszlo Otvos, Laszlo Otvos, Laszlo Otvos
doaj   +1 more source