Results 1 to 10 of about 985,533 (340)

Education and inclusive growth in West Africa [PDF]

Journal of Economics and Development, 2020
Purpose – Many West African countries face the challenge of growth inclusiveness. The region is also facing challenges of equipping its teeming population with high-quality skills despite many reforms and initiatives introduced in the past.
Oluwatosin Adeniyi, Patricia Iyore Ajayi, Abdulfatai Adekunle Adedeji   +2 more
doaj   +1 more source

Transplantation of A2 type astrocytes promotes neural repair and remyelination after spinal cord injury

Cell Communication and Signaling, 2023
Background Limited progress in terms of an effective treatment for spinal cord injury (SCI) emphasizes the urgent need for novel therapies. As a vital central nervous system component, the resident astrocytes play crucial roles in regulating recovery ...
Jie Chang, Zhanyang Qian, Binyu Wang, Jiang Cao, Shenmin Zhang, F. Jiang, Renyi Kong, Xiao Yu, Xiao-Jian Cao, Lei Yang, Hongtao Chen   +10 more
semanticscholar   +1 more source

Astrocytic A1/A2 paradigm participates in glycogen mobilization mediated neuroprotection on reperfusion injury after ischemic stroke

Journal of Neuroinflammation, 2021
Background Astrocytic glycogen works as an essential energy reserve for surrounding neurons and is reported to accumulate excessively during cerebral ischemia/reperfusion (I/R) injury.
Haiyun Guo, Ze Fan, Shi-Quan Wang, Lina Ma, Jin Wang, Doutong Yu, Zhen Zhang, Lin Wu, Zheng-Wu Peng, Wenming Liu, Wugang Hou, Yanhui Cai   +11 more
semanticscholar   +1 more source

HLA-A∗02-gated safety switch for cancer therapy has exquisite specificity for its allelic target antigen

Molecular Therapy: Oncolytics, 2022
Innovative cell-based therapies are important new weapons in the fight against difficult-to-treat cancers. One promising strategy involves cell therapies equipped with multiple receptors to integrate signals from more than one antigen.
Jee-Young Mock, Aaron Winters, Timothy P. Riley, Richele Bruno, Martin S. Naradikian, Shruti Sharma, Claudia A. Jette, Ryan Elshimali, Casey Gahrs, Dora Toledo-Warshaviak, Anthony P. West, Jr., Alexander Kamb, Agnes E. Hamburger   +12 more
doaj   +1 more source

Precision Engineering of an Anti-HLA-A2 Chimeric Antigen Receptor in Regulatory T Cells for Transplant Immune Tolerance

bioRxiv, 2021
Infusion of regulatory T cells (Tregs) engineered with a chimeric antigen receptor (CAR) targeting donor-derived human leukocyte antigen (HLA) is a promising strategy to promote transplant tolerance.
Yannick D. Muller, Leonardo M. R. Ferreira, Emilie Ronin, P. Ho, V. Nguyen, G. Faleo, Yu Zhou, Karim Lee, K. Leung, N. Skartsis, Anupurna M. Kaul, A. Mulder, F. Claas, J. Wells, J. Bluestone, Q. Tang   +15 more
semanticscholar   +1 more source

Landscape of e-Learning during Covid-19: Case Study of Economic Disciplines in Croatia

Business Systems Research, 2022
Background: The Covid-19 pandemic has changed the digitalisation level of education. Many institutions had some knowledge and practical background in delivering lectures online.
Mališ Sanja Sever, Sačer Ivana Mamić, Žager Katarina   +2 more
doaj   +1 more source

Identification of ferroptosis as a novel mechanism for antitumor activity of natural product derivative a2 in gastric cancer

Acta Pharmaceutica Sinica B, 2021
Ferroptosis is a type of cell death accompanied by iron-dependent lipid peroxidation, thus stimulating ferroptosis may be a potential strategy for treating gastric cancer, therapeutic agents against which are urgently required. Jiyuan oridonin A (JDA) is
Y. Liu, Zan Song, Yajie Liu, Xu Ma, Wang Wang, Yu Ke, Yichao Xu, Dequan Yu, Hong-Min Liu   +8 more
semanticscholar   +1 more source

Microglia induce the transformation of A1/A2 reactive astrocytes via the CXCR7/PI3K/Akt pathway in chronic post-surgical pain

Journal of Neuroinflammation, 2020
Background Activated astrocytes play important roles in chronic post-surgical pain (CPSP). Recent studies have shown reactive astrocytes are classified into A1 and A2 phenotypes, but their precise roles in CPSP remain unknown.
Ting Li, Tongtong Liu, Xu-Hui Chen, Li Li, Miaomiao Feng, Yue Zhang, L. Wan, Chuanhan Zhang, W. Yao   +8 more
semanticscholar   +1 more source

Annexin A2 in Fibrinolysis, Inflammation and Fibrosis

International Journal of Molecular Sciences, 2021
As a cell surface tissue plasminogen activator (tPA)-plasminogen receptor, the annexin A2 (A2) complex facilitates plasmin generation on the endothelial cell surface, and is an established regulator of hemostasis.
Hana I Lim, K. Hajjar
semanticscholar   +1 more source

Updating Phospholipase A2 Biology

Biomolecules, 2020
The phospholipase A2 (PLA2) superfamily contains more than 50 enzymes in mammals that are subdivided into several distinct families on a structural and biochemical basis.
M. Murakami, Hiroyasu Sato, Y. Taketomi
semanticscholar   +1 more source