Results 31 to 40 of about 529,687 (248)

The Establishment of Independence and Creativity Value of Early Childhood at TPA Taman Belia Candi Semarang

Journal of Nonformal Education, 2017
The problems of the research are (1) how the establishment of independence value of early childhood in TPA (one Daycare) of PAUD Taman Belia Candi Semarang city, (2) how the establishment of creativity value of early childhood in TPA (one Daycare) of ...
Embun Melati Widiasih, Joko Sutarto, Tri Suminar   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

V.P. Astafiev National Centre

Проект Байкал
The article presents materials on creation of the historical and cultural centre of Victor Petrovich Astafiev within the framework of the concept of sustainable development of Ovsyanka village in the Krasnoyarsk region timed to the 100th anniversary of ...
Иван Денисов , Ольга Успенская , Борис Шаталов   +2 more
doaj   +1 more source

Morphological Modelling to Investigate the Role of External Sediment Sources and Wind and Wave-Induced Flow on Sand Bank Sustainability: An Arklow Bank Case Study

Journal of Marine Science and Engineering, 2023
Offshore anthropogenic activities such as the installation of Offshore Renewable Energy (ORE) developments and sediment extraction for marine aggregates have been shown to disrupt current flow, wave propagation, and sediment transport pathways, leading ...
Shauna Creane, Michael O’Shea, Mark Coughlan, Jimmy Murphy   +3 more
doaj   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Krasnoyarsk. Transformation of the industrial territory of the EVRZ

Проект Байкал
The article deals with the territory of the industrial architectural heritage of the Krasnoyarsk Electric Railway-Car Repair Plant (EVRZ) as a place of creation of a district of modern residential development with active city life.
Константин Исмагилов , Игорь Кушнир , Ольга Успенская, Борис Шаталов   +3 more
doaj   +1 more source

Secretory Phospholipase A2

Biological and Pharmaceutical Bulletin, 2004
Secretory phospholipase A2 (sPLA2) is a growing family of structurally related, disulfide-rich, low molecular weight, lipolytic enzymes with a His-Asp catalytic dyad. sPLA2s are distributed in a wide variety of vertebrate and invertebrate animals, plants, bacteria, and viruses, and there are 10 catalytically active sPLA2 isozymes in mammals.
Murakami, Makoto, Kudo, Ichiro
openaire   +3 more sources

A2 milk is allergenic [PDF]

Medical Journal of Australia, 2004
The document attached has been archived with permission from the editor of the Medical Journal of Australia. An external link to the publisher’s copy is included.
Smith, W., Thompson, D., Kummerow, M., Quinn, P., Gold, M.   +4 more
openaire   +3 more sources

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source