Role of Phospholipases in Fungal Fitness, Pathogenicity and Drug Development- Lessons from Cryptococcus neoformans [PDF]
Frontiers in Microbiology, 2010 Many pathogenic microbes, including many fungi, produce phospholipases which facilitate survival of the pathogen in vivo, invasion and dissemination throughout the host, expression of virulence traits and evasion of host immune defense mechanisms.
Julianne eDjordjevic
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Search for and functional annotation of multi-domain PLA2 family proteins in flatworms
Вавиловский журнал генетики и селекцииThe phospholipase A2 (PLA2) is a superfamily of hydrolases that catalyze the hydrolysis of phospholipids and play a key role in many molecular processes in the cells and the organism as a whole.
M. E. Bocharnikova +2 more
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Recent Advances in the Cellular and Developmental Biology of Phospholipases in Plants
Frontiers in Plant Science, 2019 Phospholipases (PLs) are lipid-hydrolyzing enzymes known to have diverse signaling roles during plant abiotic and biotic stress responses. They catalyze lipid remodeling, which is required to generate rapid responses of plants to environmental cues ...
Tomáš Takač +2 more
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Molecular effects of clinically relevant chemotherapeutic agents on choline phospholipid metabolism in triple negative breast cancer cells [PDF]
Translational OncologyTriple-negative breast cancer (TNBC) is the most lethal breast cancer subtype, leading to poor patient outcomes despite aggressive treatment with surgery, radiation, and chemotherapy. There are currently no clinical tests available which measure early on
Caitlin M. Tressler +5 more
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F1000Research, 2021 Background: Phospholipases are enzymes with the capacity to hydrolyze membrane lipids and have been characterized in several allergenic sources, such as hymenoptera species.
Yuliana Emiliani +4 more
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Phospholipases in Gliomas: Current Knowledge and Future Perspectives from Bench to Bedside
Biomolecules, 2023 Phospholipases are essential intermediaries that work as hydrolyzing enzymes of phospholipids (PLs), which represent the most abundant species contributing to the biological membranes of nervous cells of the healthy human brain.
Maria Vittoria Marvi +15 more
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Phospholipases A and Lysophospholipases in protozoan parasites
Microbial Cell, 2023 Phospholipases (PLs) and Lysophospholipases (LysoPLs) are a diverse group of esterases responsible for phospholipid or lysophospholipid hydrolysis. They are involved in several biological processes, including lipid catabolism, modulation of the immune ...
Perrine Hervé +3 more
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Human phospholipases A2: a functional and evolutionary analysis
Вавиловский журнал генетики и селекции, 2023 Phospholipases A2 (PLA2) are capable of hydrolyzing the sn-2 position of glycerophospholipids to release fatty acids and lysophospholipids. The PLA2 superfamily enzymes are widespread and present in most mammalian cells and tissues, regulating metabolism,
I. I. Turnaev +2 more
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Interface of Phospholipase Activity, Immune Cell Function, and Atherosclerosis
Biomolecules, 2020 Phospholipases are a family of lipid-altering enzymes that can either reduce or increase bioactive lipid levels. Bioactive lipids elicit signaling responses, activate transcription factors, promote G-coupled-protein activity, and modulate membrane ...
Robert M. Schilke +3 more
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Signal-activated phospholipase regulation of leukocyte chemotaxis
Journal of Lipid Research, 2009 Signal-activated phospholipases are a recent focus of the rapidly growing field of lipid signaling. The extent of their impact on the pathways regulating diverse cell functions is beginning to be appreciated.
Martha K. Cathcart
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