Results 1 to 10 of about 1,256,195 (268)

Identification of small molecules as novel anti-adipogenic compounds based on Connectivity Map

Frontiers in Endocrinology, 2022
Several physiological and pathological conditions such as aging, obesity, diabetes, anorexia nervosa are associated with increased adipogenesis in the bone marrow.
Shuang Zhang, Nicholas Lyons, Marijke Koedam, Jeroen van de Peppel, Johannes P.T.M. van Leeuwen, Bram C. J. van der Eerden   +5 more
doaj   +1 more source

Calcium channelopathies [PDF]

Kidney International, 2000
Calcium is an important intracellular signaling molecule, and altered calcium channel function can cause widespread cellular changes. Genetic mutations in calcium channels that cause what appear to be trivial alterations of calcium currents in vitro can result in serious diseases in muscles and the nervous system.
Lorenzon, Nancy M., Beam, Kurt G.
openaire   +2 more sources

Titanium Dioxide Promotes the Growth and Aggregation of Calcium Phosphate and Monosodium Urate Mixed Crystals

Crystals, 2023
The increased utilization of titanium dioxide (TiO2) nanoparticles (TNPs) in various industrial and consumer products has raised concerns regarding its harmful effect due to its accumulation within the different systems of the human body.
Onyebuchi C. Ukaeje, Bidhan C. Bandyopadhyay   +1 more
doaj   +1 more source

Heterogeneous Phosphotungstate Catalyst Mediated Efficient Alcoholysis of Furfuryl Alcohol into Long-Chain Levulinates

BioResources, 2023
The synthesis of alternative fuels from biomass has emerged to be a vital strategy to maintain sustainable development. Long-chain levulinate esters (LEs) are a class of good biofuel candidates because they have similar structures to biodiesels and ...
Yinghui Wang, Jiao Ma, Qiang Zheng, Yali Ma, Songyan Jia, Xue Li   +5 more
doaj   +2 more sources

Calcitonin Gene-Related Peptide (Cgrp), Adrenomedullin (Am), Amylin, And Calcitonin (Ct) Receptors And Overlapping Biological Actions

The Scientific World Journal, 2001
CGRP, AM, amylin, and CT have in common N-terminal 6-7 amino acid ring structures linked by disulfide bridges and amidated C-termini required for biological activity.
J.A. Fischer, W. Born, R. Muff
doaj   +1 more source

Calcium signaling [PDF]

Cell, 1995
Calcium ions (Ca(2+)) impact nearly every aspect of cellular life. This review examines the principles of Ca(2+) signaling, from changes in protein conformations driven by Ca(2+) to the mechanisms that control Ca(2+) levels in the cytoplasm and organelles.
openaire   +3 more sources

Protein kinase A modulation of CaV1.4 calcium channels

Nature Communications, 2016
Phosphorylation of L-type calcium CaV channels by protein kinase A is essential for several physiological events. Here, the authors show how this kinase regulates CaV1.4 activity, suggesting a general regulatory mechanism for all L-type calcium channels.
Lingjie Sang, Ivy E. Dick, David T. Yue
doaj   +1 more source

Study on Process Mineralogy of a High Iron Potassium Feldspar from Jilin Province

Kuangchan zonghe liyong, 2022
By means of X-ray diffraction analysis, scanning electron probe microanalysis and optical microscopy, the chemical composition and mineral intercalation and particle size composition of potassium feldspar in Jilin were studied. The results show that main
Jiao Peng, Hongjun Huang, Pan Wang, Junjie Yu, Fangfang Liu   +4 more
doaj   +1 more source

Downregulation of TrkC Receptors Increases Dendritic Arborization of Purkinje Cells in the Developing Cerebellum of the Opossum, Monodelphis domestica

Frontiers in Neuroanatomy, 2020
In therian mammals, the cerebellum is one of the late developing structures in the brain. Specifically, the proliferation of cerebellar granule cells occurs after birth, and even in humans, the generation of these cells continues during the first year of
Beata Tepper, Katarzyna Bartkowska, Malgorzata Okrasa, Sonia Ngati, Magdalena Braszak, Krzysztof Turlejski, Ruzanna Djavadian   +6 more
doaj   +1 more source

A novel synonymous variant in exon 1 of GNAS gene results in a cryptic splice site and causes pseudohypoparathyroidism type 1A and pseudo-pseudohypoparathyroidism in a French family

Bone Reports, 2021
Introduction: Pseudohypoparathyroidism type 1A (PHP1A) and pseudopseudohypoparathyroidism (PPHP) (Inactivating PTH/PTHrP Signaling Disorders type 2, IPPSD2) are two rare autosomal disorders caused by loss-of-function mutations on either maternal or ...
Andreea Apetrei, Arnaud Molin, Nicolas Gruchy, Manon Godin, Claire Bracquemart, Antoine Resbeut, Gaëlle Rey, Gwenaël Nadeau, Nicolas Richard   +8 more
doaj   +1 more source