Results 21 to 30 of about 1,256,195 (268)
Scientific Reports, 2022 The endocannabinoid system has been postulated to help restrict cancer progression and maintain osteoblastic function during bone metastasis. Herein, the effects of cannabinoid receptor (CB) type 1 and 2 activation on breast cancer cell and osteoblast ...
Tueanjai Khunluck +7 more
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Calcium-induced calcium release [PDF]
Current Biology, 2003 Why is calcium so important? Intracellular calcium controls a diverse array of cellular processes from fertilisation through gene transcription, muscle contraction to cell death. Changes in calcium levels can occur in microseconds or hours, they can be microscopic or propagate throughout cells and tissues.How are calcium levels increased within cells ...
Roderick, H. Llewelyn +2 more
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Binding epitope for recognition of human TRPM4 channel by monoclonal antibody M4M
Scientific Reports, 2022 Mouse monoclonal antibody M4M was recently designed to block human TRPM4 channel. The polypeptide for generating M4M is composed of peptide A1 between the transmembrane segment 5 (S5) and the pore, and a second peptide A2 between the pore and the ...
Shunhui Wei +6 more
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Relative Bioavailability of Calcium from Calcium Formate, Calcium Citrate, and Calcium Carbonate [PDF]
The Journal of Pharmacology and Experimental Therapeutics, 2005 Calcium is an essential nutrient required in substantial amounts, but many diets are deficient in calcium making supplementation necessary or desirable. The objective of this study was to compare the oral bioavailability of calcium from calcium formate, a new experimental dietary calcium supplement, to that of calcium citrate and calcium carbonate.
Hanzlik, Robert P. +2 more
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Frontiers in Immunology, 2018 S100A8 and S100A9 are members of the S100 family of cytoplasmic EF-hand Ca2+-binding proteins and are abundantly expressed in the cytosol of neutrophils. In addition to their intracellular roles, S100A8/A9 can be secreted in the extracellular environment
Véronique Schenten +7 more
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Genes and Diseases, 2022 Proximal tubule (PT) transports most of the renal Ca2+, which was usually described as paracellular (passive). We found a regulated Ca2+ entry pathway in PT cells via the apical transient receptor potential canonical 3 (TRPC3) channel, which initiates ...
Samuel Shin +5 more
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HSPB7 oppositely regulates human mesenchymal stromal cell-derived osteogenesis and adipogenesis
Stem Cell Research & Therapy, 2023 Background Recent evidence suggests that accumulation of marrow adipose tissue induced by aberrant lineage allocation of bone marrow-derived mesenchymal stromal cells (BMSCs) contributes to the pathophysiologic processes of osteoporosis.
Shuang Zhang +4 more
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Melamine promotes calcium crystal formation in three-dimensional microfluidic device
Scientific Reports, 2019 Melamine, which induces proximal tubular (PT) cell damage has a greater nephrotoxic effect when combined with cyanuric and uric acids; however, it is unknown whether such effect can stimulate calcium phosphate (CaP)/calcium oxalate (CaOx) stone formation.
Farai Gombedza +6 more
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Calcium Signalling: Calcium Goes Global [PDF]
Current Biology, 2002 Recent evidence suggests that multiple calcium-releasing messengers might be activated simultaneously to regulate patterns of intracellular calcium signalling. In this way, agonists might use different messenger cocktails to encode specific signals and target selected processes.
Genazzani, Armando A., Thorn, Peter
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The Scientific World Journal, 2001 Cell surface protein cross-linking, coimmmunoprecipitation, and confocal microscopy identified CRLR/RAMP1-, CRLR/RAMP2-, and calcitonin receptor isotype 2 (CTR2)/RAMP1 heterodimers as CGRP-, AM-, and CGRP/amylin receptors, linked to cAMP production ...
W. Born +4 more
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