Results 1 to 10 of about 101,239 (161)

Pentagalloyl glucose suppresses MSU crystal–induced gout inflammation and arachidonic acid production in vitro and in vivo [PDF]

Frontiers in Pharmacology
BackgroundGout is an acute inflammatory arthritis triggered by monosodium urate (MSU) crystal deposition and activation of innate immune responses.
Sadiq Umar, Yu Lu, Sugasini Dhavamani, Poorna C. R. Yalagala, Mateusz S. Wietecha, Sriram Ravindran   +5 more
doaj   +2 more sources

Arachidonic acid depletion extends survival of cold-stored platelets by interfering with the [glycoprotein Ibα – 14-3-3ζ] association

Haematologica, 2012
Background Cold storage of platelets reduces bacterial growth and preserves their hemostatic properties better than current procedures do. However, storage at 0°C induces [14-3-3ζ-glycoprotein Ibα] association, 14-3-3ζ release from phospho-Bad, Bad ...
Dianne E. van der Wal, Eelo Gitz, Vivian X. Du, Kimberly S.L. Lo, Cornelis A. Koekman, Sabine Versteeg, Jan Willem N. Akkerman   +6 more
doaj   +1 more source

Increasing dietary linoleic acid does not increase tissue arachidonic acid content in adults consuming Western-type diets: a systematic review

Nutrition & Metabolism, 2011
Background Linoleic acid, with a DRI of 12-17 g/d, is the most highly consumed polyunsaturated fatty acid in the Western diet and is found in virtually all commonly consumed foods.
Whelan Jay, Rett Brian S
doaj   +1 more source

The Contribution of Cytosolic Group IVA and Calcium-Independent Group VIA Phospholipase A₂s to Adrenic Acid Mobilization in Murine Macrophages

Biomolecules, 2020
Adrenic acid (AA), the 2-carbon elongation product of arachidonic acid, is present at significant levels in membrane phospholipids of mouse peritoneal macrophages.
Patricia Monge, Alvaro Garrido, Julio M. Rubio, Victoria Magrioti, George Kokotos, María A. Balboa, Jesús Balsinde   +6 more
doaj   +1 more source

Chronic N-methyl-d-aspartate administration increases the turnover of arachidonic acid within brain phospholipids of the unanesthetized rat

Journal of Lipid Research, 2008
Whereas antibipolar drug administration to rats reduces brain arachidonic acid turnover, excessive N-methyl-d-aspartate (NMDA) signaling is thought to contribute to bipolar disorder symptoms and may increase arachidonic acid turnover in rat brain ...
Ho-Joo Lee, Jagadeesh S. Rao, Lisa Chang, Stanley I. Rapoport, Richard P. Bazinet   +4 more
doaj   +1 more source

Arachidonic Acid and the Brain [PDF]

The Journal of Nutrition, 2008
Kinetic methods in unanesthetized rodents have shown that turnover rates of arachidonic acid (AA) and docosahexaenoic acid (DHA) in brain membrane phospholipids are rapid and energy consuming and that phospholipase A(2) (PLA(2)) and acyl-CoA synthetase enzymes that regulate turnover are specific for one or the other PUFA.
openaire   +2 more sources

Metabolism of arachidonic acid-l-14C in the rat

Journal of Lipid Research, 1965
The metabolism of arachidonic acid-1-14C has been studied in the rat. The acid was fed as a component of randomly rearranged soybean oil; its absorption was greater than 96%.
Robert H. Coots
doaj   +1 more source

Arachidonic acid-dependent inhibition of adipocyte differentiation requires PKA activity and is associated with sustained expression of cyclooxygenases

Journal of Lipid Research, 2003
Arachidonic acid inhibits adipocyte differentiation of 3T3-L1 cells via a prostaglandin synthesis-dependent pathway. Here we show that this inhibition requires the presence of a cAMP-elevating agent during the first two days of treatment.
Rasmus K. Petersen, Claus J⊘rgensen, Arild C. Rustan, Livar Fr⊘yland, Karin Muller-Decker, Gerhard Furstenberger, Rolf K. Berge, Karsten Kristiansen, Lise Madsen   +8 more
doaj   +1 more source

Arachidonic acid enhances turnover of the dermal skeleton: studies on zebrafish scales.

PLoS ONE, 2014
In fish nutrition, the ratio between omega-3 and omega-6 poly-unsaturated fatty acids influences skeletal development. Supplementation of fish oils with vegetable oils increases the content of omega-6 fatty acids, such as arachidonic acid in the diet ...
Erik de Vrieze, Mari Moren, Juriaan R Metz, Gert Flik, Kai Kristoffer Lie   +4 more
doaj   +1 more source

Metabolism of n-3 polyunsaturated fatty acids and modification of phospholipids in cultured rabbit aortic smooth muscle cells.

Journal of Lipid Research, 1985
The metabolism of the linolenic acid family (n-3) of fatty acids, e.g., linolenic, eicosapentaenoic, and docosahexaenoic acids, in cultured smooth muscle cells from rabbit aorta was compared to the metabolism of linoleic and arachidonic acids.
N Morisaki, T Kanzaki, Y Fujiyama, I Osawa, K Shirai, N Matsuoka, Y Saito, S Yoshida   +7 more
doaj   +1 more source