Results 11 to 20 of about 183,297 (300)

KIF18A induces the EMT process of hepatoma cells through the 5-LOX-dependent arachidonic acid pathway. [PDF]

PLoS ONE
The high morbidity and mortality rates of liver cancer prompt us to constantly explore new therapeutic strategies. The arachidonic acid metabolism-related pathways play a crucial regulatory role in the growth, invasion and angiogenesis of liver cancer ...
Yibo Wang, Tao Cai, Yajie Chen, Wenpeng Liu, Baowang Liu, Xin Zhao, Yang Wang, Jinglin Cao, Qiang Zeng   +8 more
doaj   +2 more sources

Frataxin deficiency increases cyclooxygenase 2 and prostaglandins in cell and animal models of Friedreich's ataxia. [PDF]

, 2014
An inherited deficiency of the mitochondrial protein frataxin causes Friedreich's ataxia (FRDA); the mechanism by which this deficiency triggers neuro- and cardio-degeneration is unclear.
Cortopassi, Gino, Hayashi, Genki, Newman, John W, Pedersen, Theresa L, Pook, Mark, Shen, Yan   +5 more
core   +4 more sources

Pharmacometabolomics reveals racial differences in response to atenolol treatment. [PDF]

, 2013
Antihypertensive drugs are among the most commonly prescribed drugs for chronic disease worldwide. The response to antihypertensive drugs varies substantially between individuals and important factors such as race that contribute to this heterogeneity ...
Beitelshees, Amber L, Boyle, Stephen, Chapman, Arlene B, Churchill, Erik, Cooper-Dehoff, Rhonda M, Fiehn, Oliver, Frye, Reginald F, Gong, Yan, Johnson, Julie A, Kaddurah-Daouk, Rima, Pharmacometabolomics Research Network, Wikoff, William R, Zhu, Hongjie   +12 more
core   +14 more sources

Arachidonic acid depletion extends survival of cold-stored platelets by interfering with the [glycoprotein Ibα – 14-3-3ζ] association

Haematologica, 2012
Background Cold storage of platelets reduces bacterial growth and preserves their hemostatic properties better than current procedures do. However, storage at 0°C induces [14-3-3ζ-glycoprotein Ibα] association, 14-3-3ζ release from phospho-Bad, Bad ...
Dianne E. van der Wal, Eelo Gitz, Vivian X. Du, Kimberly S.L. Lo, Cornelis A. Koekman, Sabine Versteeg, Jan Willem N. Akkerman   +6 more
doaj   +1 more source

Mechanism of NaCl transport-stimulated prostaglandin formation in MDCK cells [PDF]

, 1987
Recently we have found that stimulation of NaCl transport in high-resistance MDCK cells enhances their prostaglandin formation. In the present study, we investigated the mechanisms by which prostaglandin formation could be linked to the ion transport in ...
Bauer, C., Kurtz, Armin, Malmström, K., Pfeilschifter, J., Woodson, R. D.   +4 more
core   +1 more source

Increasing dietary linoleic acid does not increase tissue arachidonic acid content in adults consuming Western-type diets: a systematic review

Nutrition & Metabolism, 2011
Background Linoleic acid, with a DRI of 12-17 g/d, is the most highly consumed polyunsaturated fatty acid in the Western diet and is found in virtually all commonly consumed foods.
Whelan Jay, Rett Brian S
doaj   +1 more source

The Contribution of Cytosolic Group IVA and Calcium-Independent Group VIA Phospholipase A₂s to Adrenic Acid Mobilization in Murine Macrophages

Biomolecules, 2020
Adrenic acid (AA), the 2-carbon elongation product of arachidonic acid, is present at significant levels in membrane phospholipids of mouse peritoneal macrophages.
Patricia Monge, Alvaro Garrido, Julio M. Rubio, Victoria Magrioti, George Kokotos, María A. Balboa, Jesús Balsinde   +6 more
doaj   +1 more source

Cyclosporin A inhibits PGE2 release from vascular smooth muscle cells [PDF]

, 1987
The influence of the fungoid undecapeptide cyclosporin A (CyA) on PGE2 release from cultured rat aortic smooth muscle cells was investigated in this study.
Koch, K. M., Kurtz, Armin, Kühn, K., Pfeilschifter, J.   +3 more
core   +1 more source

Chronic N-methyl-d-aspartate administration increases the turnover of arachidonic acid within brain phospholipids of the unanesthetized rat

Journal of Lipid Research, 2008
Whereas antibipolar drug administration to rats reduces brain arachidonic acid turnover, excessive N-methyl-d-aspartate (NMDA) signaling is thought to contribute to bipolar disorder symptoms and may increase arachidonic acid turnover in rat brain ...
Ho-Joo Lee, Jagadeesh S. Rao, Lisa Chang, Stanley I. Rapoport, Richard P. Bazinet   +4 more
doaj   +1 more source

Arachidonic Acid as a Possible Negative Feedback Inhibitor of Nicotinic Acetylcholine Receptors on Neurons [PDF]

, 1995
Neuronal acetylcholine receptors, being highly permeable to calcium, are likely to regulate calcium-dependent events in neurons. Arachidonic acid is a membrane-permeant second messenger that can be released from membrane phospholipids by phospholipases ...
Berg, Darwin K., Blumenthal, Edward M, Huang, Bo, Vijayaraghavan, Sukumar   +3 more
core   +2 more sources