Results 1 to 10 of about 69,164 (164)

Allosteric regulation of prostaglandin endoperoxide H₂ synthases. [PDF]

J Biol Chem
Prostaglandin Endoperoxide H2 Synthases (PGHS-1 and PGHS-2), also referred to as cyclooxygenases (COX-1 and COX-2), are homodimeric enzymes that oxygenate arachidonic acid (AA) to generate Prostaglandin H2 (PGH2), the precursor to prostaglandins, prostacyclin, and thromboxane.
Dong L, Malkowski MG.
europepmc   +3 more sources

Prostaglandin pathways in equine myometrium regulations: endometrosis progression [PDF]

Frontiers in Veterinary Science
IntroductionProstaglandins (PG) are important regulators of the myometrial contractility in mammals. Endometrosis, a condition characterized by morphological changes in the equine endometrium, also affects endometrial secretory function.
Katarzyna K. Piotrowska-Tomala, Anna Z. Szóstek-Mioduchowska, Ewa M. Drzewiecka, Ewa M. Drzewiecka, Agnieszka W. Jonczyk, Anna Wójtowicz, Michał H. Wrobel, Graca Ferreira-Dias, Graca Ferreira-Dias, Dariusz J. Skarzynski   +9 more
doaj   +2 more sources

The Expression Pattern of Prostaglandin-Endoperoxide Synthase-2 in Immature Oocytes and Surrounding Cumulus Cells May Explain A Disrupted Oocyte Maturation Process

Gynecology Obstetrics & Reproductive Medicine, 2021
Objective: To evaluate the correlation between the gene expression of prostaglandin-endoperoxide synthase-2 in the cumulus-oocyte complex with the level of prostaglandin-endoperoxide synthase-2 in follicular fluid and follicle diameter, oocyte ...
Goktan Kuspinar, Berrin Avcı
doaj   +1 more source

Prostaglandin Endoperoxide H Synthases (Cyclooxygenases)-1 and −2 [PDF]

Journal of Biological Chemistry, 1996
R Michael Garavito, David L Dewitt, D L Dewitt   +2 more
exaly   +3 more sources

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

Cyclooxygenase-2 expression in cervical cancer [PDF]

Vojnosanitetski Pregled, 2014
Background/Aim. Cyclooxygenase (COX) or prostaglandin H2 synthase is the first enzyme that catalyzes the first two steps in the biosynthesis of prostaglandins from arachidonic acid.
Mandić Aljoša, Ušaj-Knežević Slavica, Ivković-Kapicl Tatjana, Ninčić Dejan, Malenković Goran   +4 more
doaj   +1 more source

Nitro-fatty acids: novel anti-inflammatory lipid mediators

Brazilian Journal of Medical and Biological Research, 2013
Nitro-fatty acids are formed and detected in human plasma, cell membranes, and tissue, modulating metabolic as well as inflammatory signaling pathways.
H. Rubbo
doaj   +1 more source

Flipping the cyclooxygenase (Ptgs) genes reveals isoform-specific compensatory functions1,2[S]

Journal of Lipid Research, 2018
Two prostaglandin (PG) H synthases encoded by Ptgs genes, colloquially known as cyclooxygenase (COX)-1 and COX-2, catalyze the formation of PG endoperoxide H2, the precursor of the major prostanoids.
Xinzhi Li, Liudmila L. Mazaleuskaya, Chong Yuan, Laurel L. Ballantyne, Hu Meng, William L. Smith, Garret A. FitzGerald, Colin D. Funk   +7 more
doaj   +1 more source

Highly Selective Cyclooxygenase-1 Inhibitors P6 and Mofezolac Counteract Inflammatory State both In Vitro and In Vivo Models of Neuroinflammation

Frontiers in Neurology, 2017
Activated microglia secrete an array of pro-inflammatory factors, such as prostaglandins, whose accumulation contributes to neuronal damages. Prostaglandin endoperoxide synthases or cyclooxygenases (COX-1 and COX-2), which play a critical role in the ...
Rosa Calvello, Dario Domenico Lofrumento, Maria Grazia Perrone, Antonia Cianciulli, Rosaria Salvatore, Paola Vitale, Francesco De Nuccio, Laura Giannotti, Giuseppe Nicolardi, Maria Antonietta Panaro, Antonio Scilimati   +10 more
doaj   +1 more source

Topography of the Prostaglandin Endoperoxide H2 Synthase-2 in Membranes [PDF]

Journal of Biological Chemistry, 2006
The topology of association of the monotopic protein cyclooxygenase-2 (COX-2) with membranes has been examined using EPR spectroscopy of spin-labeled recombinant human COX-2. Twenty-four mutants, each containing a single free cysteine substituted for an amino acid in the COX-2 membrane binding domain were expressed using the baculovirus system and ...
Zahra, MirAfzali, Jeffrey R, Leipprandt, John L, McCracken, David L, DeWitt   +3 more
openaire   +2 more sources