Lipid Raft Membrane Interactivity Correlating with Cyclooxygenase-2 Selectivity of Non-Steroidal Anti-Inflammatory Drugs [PDF]
MembranesThe primary mechanism of non-steroidal anti-inflammatory drugs (NSAIDs) is inhibition of prostaglandin production mediated by cyclooxygenase. Given the possible association of cyclooxygenase-2, but not cyclooxygenase-1, with membrane lipid rafts, we ...
Maki Mizogami +2 more
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Endothelin-1 upregulates cyclooxygenase-2 expression and prostaglandin E2 synthesis in human periodontal ligament cells—an in vitro study [PDF]
Journal of Orthodontic ScienceAIMS: Endothelin-1 (ET-1) increased bone resorption during orthodontic tooth movement (OTM) in animal models, suggesting potential clinical applications for accelerating OTM.
Supachai Unmanatakoon +1 more
doaj +2 more sources
Prostaglandin Synthase 2/Cyclooxygenase 2 Gene Polymorphisms and Susceptibility to Urothelial Bladder Cancer in an Iranian Population [PDF]
Middle East Journal of Cancer, 2022 Background: Prostaglandin-endoperoxide synthase 2, recognized as cyclooxygenase 2 (COX-2), is an important enzyme contributing to the generation of proinflammatory prostaglandins.
Kamyar Mansori +3 more
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Upregulation of prostaglandin E by inducible microsomal prostaglandin E synthase-1 in colon cancer [PDF]
Annals of Coloproctology, 2022 Purpose Prostaglandin E2 (PGE2) is known to promote carcinogenesis and cancer progression in colon cancer. Enzymes involved in the metabolism of PGE2 include cyclooxygenase (COX)-2, microsomal prostaglandin E synthase-1 (mPGES-1), and 15-prostaglandin ...
Young Hun Kim, Kyung Jong Kim
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Targeting the Aryl Hydrocarbon Receptor Signaling Pathway in Breast Cancer Development
Frontiers in Immunology, 2021 Activation of the aryl hydrocarbon receptor (AhR) through environmental exposure to known human carcinogens including dioxins can lead to the promotion of breast cancer.
Christoph F. A. Vogel +16 more
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Correlation of COX- 2 Expression in Colorectal Carcinoma with Clinicopathological Features [PDF]
Türk Patoloji Dergisi, 2017 Objective: Colorectal carcinoma is the most common neoplasm of the gastrointestinal tract. COX-2 expression is upregulated in colorectal carcinoma. Therefore its assessment would identify patients amenable to adjuvant anticyclooxygenase therapy.
Sandhya VENKATACHALA, Manjula RAJENDRAN
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Pharmaceuticals, 2023 Electrospraying (ES) technology is considered an efficient micro/nanoparticle fabrication technique with controlled dimensions and diverse morphology.
Samar Zuhair Alshawwa +5 more
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Genetic Variants in COX2 and ALOX Genes and Breast Cancer Risk in White and Black Women
Frontiers in Oncology, 2021 COX and ALOX genes are involved in inflammatory processes and that may be related to breast cancer risk differentially between White and Black women. We evaluated distributions of genetic variants involved in COX2 and ALOX-related pathways and examined ...
Jennifer M. Mongiovi +10 more
doaj +1 more source
Endometritis in the bitch: Immunohistochemical localization of cyclooxygenase 2 [PDF]
Open Veterinary Journal, 2020 Background: In several mammals, subfertility or infertility associated with endometritis was reported. Although there have been studies about endometritis in bitches, the pathophysiological mechanisms it is not completely known. Aim: This study aimed to
María Carla García Mitacek +4 more
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BMC Endocrine Disorders, 2020 Background Pituitary adenomas as multifactorial intracranial neoplasms impose a massive burden of morbidity on patients and characterizing the molecular mechanism underlying their pathogenesis has received considerable attention.
Nasrin Akbari +9 more
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