Results 1 to 10 of about 25,667 (117)
Clinics, 2018 Eicosanoids are 20-carbon bioactive lipids derived from the metabolism of polyunsaturated fatty acids, which can modulate various biological processes including cell proliferation, adhesion and migration, angiogenesis, vascular permeability and ...
Alison Colquhoun +1 more
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Eicosanoids and Oxidative Stress in Diabetic Retinopathy
Antioxidants, 2020 Oxidative stress is an important factor to cause the pathogenesis of diabetic retinopathy (DR) because the retina has high vascularization and long-time light exposition.
Mohamed Al-Shabrawey +2 more
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Transpulmonary eicosanoid metabolite gradients: insights into metabolic flux of pro- and anti-inflammatory metabolites and lung function [PDF]
ERJ Open ResearchIntroduction Eicosanoids are upstream lipid mediators of inflammatory pathways. Transpulmonary gradient (ΔEIC) analysis using multisite sampling enables physiological assessment of metabolic flux across the lungs.
Louisa A. Mounsey +8 more
doaj +2 more sources
Eicosanoids in inflammation in the blood and the vessel
Frontiers in Pharmacology, 2022 Polyunsaturated fatty acids (PUFAs) are structural components of membrane phospholipids in cells. PUFAs regulate cellular function through the formation of derived lipid mediators termed eicosanoids.
Adriana Yamaguchi +3 more
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The association between eicosanoids and incident atrial fibrillation in the Framingham Heart Study
Scientific Reports, 2022 Chronic inflammation is a continuous low-grade activation of the systemic immune response. Whereas downstream inflammatory markers are associated with atrial fibrillation (AF), upstream inflammatory effectors including eicosanoids are less studied.
Jelena Kornej +11 more
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Scientific Reports, 2021 The association between matrix metalloproteinases (MMPs), tissue inhibitor of metalloproteinases (TIMPs) and obesity as well as obesity-related disease including metabolic syndrome is not fully explored.
Soumaya Boumiza +5 more
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Eicosanoid profiling in an orthotopic model of lung cancer progression by mass spectrometry demonstrates selective production of leukotrienes by inflammatory cells of the microenvironment. [PDF]
PLoS ONE, 2013 Eicosanoids are bioactive lipid mediators derived from arachidonic acid(1) (AA), which is released by cytosolic phospholipase A2 (cPLA2). AA is metabolized through three major pathways, cyclooxygenase (COX), lipoxygenase (LO) and cytochrome P450, to ...
Joanna M Poczobutt +9 more
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A genome-wide association study identifies 41 loci associated with eicosanoid levels
Communications Biology, 2023 Eicosanoids are biologically active derivatives of polyunsaturated fatty acids with broad relevance to health and disease. We report a genome-wide association study in 8406 participants of the Atherosclerosis Risk in Communities Study, identifying 41 ...
Eugene P. Rhee +9 more
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PLoS Medicine, 2020 BackgroundInflammation during pregnancy is hypothesized to influence fetal growth. Eicosanoids, an important class of lipid mediators derived from polyunsaturated fatty acids, can act as both direct influences and biomarkers of inflammation through a ...
Barrett M Welch +8 more
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Journal of Lipid Research, 2007 Human 15-lipoxygenase (LOX)-2 and mouse 8-LOX represent orthologous members of the LOX family but display different positional specificities and tissue distribution. To study the functional role of 15-LOX-2 and 8-LOX in keratinocytes, an inducible Tet-On
Dorothea Schweiger +2 more
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