Results 21 to 30 of about 24,894 (189)
A genome-wide association study identifies 41 loci associated with eicosanoid levels
Communications Biology, 2023 Eicosanoids are biologically active derivatives of polyunsaturated fatty acids with broad relevance to health and disease. We report a genome-wide association study in 8406 participants of the Atherosclerosis Risk in Communities Study, identifying 41 ...
Eugene P. Rhee +9 more
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PLoS Medicine, 2020 BackgroundInflammation during pregnancy is hypothesized to influence fetal growth. Eicosanoids, an important class of lipid mediators derived from polyunsaturated fatty acids, can act as both direct influences and biomarkers of inflammation through a ...
Barrett M Welch +8 more
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Journal of Lipid Research, 2007 Human 15-lipoxygenase (LOX)-2 and mouse 8-LOX represent orthologous members of the LOX family but display different positional specificities and tissue distribution. To study the functional role of 15-LOX-2 and 8-LOX in keratinocytes, an inducible Tet-On
Dorothea Schweiger +2 more
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Eicosanoids: Atherosclerosis and cardiometabolic health
Journal of Clinical & Translational Endocrinology, 2020 Cardiovascular diseases (CVD) have been the leading causes of death in the U.S. for nearly a century. Numerous studies have linked eicosanoids to cardiometabolic disease.
Kimberly Piper, Mahdi Garelnabi
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Nature Reviews Cancer, 2010 Eicosanoids, including prostaglandins and leukotrienes, are biologically active lipids that have been implicated in various pathological processes, such as inflammation and cancer. This Review highlights our understanding of the intricate roles of eicosanoids in epithelial-derived tumours and their microenvironment.
Dingzhi, Wang, Raymond N, Dubois
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Environment International, 2023 Humans are exposed to complex mixtures of phthalates. Gestational exposure to phthalates has been linked to preeclampsia and preterm birth through potential pathways such as endocrine disruption, oxidative stress, and inflammation.
Seonyoung Park +11 more
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ENDOCANNABINOIDS AND EICOSAMOIDS: BIOSYNTHESIS AND INTERACTIONS WITH IMMUNE RESPONSE
Медицинская иммунология, 2014 The review is dedicated to modern concepts of arachidonic acid metabolites, i.e., endocannabinoids and eicosanoids, their biosynthetic pathways, cross-talk mechanisms and participation in immune response.
Yu. K. Karaman, E. G. Lobanova
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Candida albicans and Pseudomonas aeruginosa interaction, with focus on the role of eicosanoids
Frontiers in Physiology, 2016 Candida albicans is commonly found in mixed infections with Pseudomonas aeruginosa, especially in the lungs of cystic fibrosis patients. Both of these opportunistic pathogens are able to form resistant biofilms and frequently infect immunocompromised ...
Ruan eFourie +6 more
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Study of the role of cytosolic phospholipase A2 alpha in eicosanoid generation and thymocyte maturation in the thymus. [PDF]
PLoS ONE, 2015 The thymus is a primary lymphoid organ, home of maturation and selection of thymocytes for generation of functional T-cells. Multiple factors are involved throughout the different stages of the maturation process to tightly regulate T-cell production ...
Matthieu Rousseau +5 more
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Metabolites, 2022 Eicosanoids are lipid mediators generated from arachidonic acid with pro- and anti-inflammatory properties. Despite these lipid mediators being known for decades, quantitative determination in biological samples is still challenging due to low abundance,
Louis Schmidt +4 more
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