Results 31 to 40 of about 31,692 (187)
浙江大学学报. 农业与生命科学版, 2016 Eicosanoids, which mediate various physiological and pathophysiological processes, are mainly formed from C20 polyunsaturated fatty acids (PUFAs) such as arachidonic acid (AA,20:4n-6) and eicosapentaenoic acid (EPA,20:5n - 3) through cyclooxygenases (COX)
TAN Liangliang, SHEN Lirong
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Cancer Medicine, 2022 Background Numerous studies have investigated the possible involvement of eicosanoids, lysophospholipids, and sphingolipids in cancer. We considered that comprehensive measurement of these lipid mediators might provide a better understanding of their ...
Makoto Kurano, Eri Sakai, Yutaka Yatomi
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Advanced Science, EarlyView.The Tuta absoluta salivary effector TaCRVP subverts tomato immunity by hijacking host catalase SlCAT2. Through a sophisticated dual mechanism, TaCRVP simultaneously promotes SlCAT2 tetramerization for activation and blocks its SlAdBiL‐mediated degradation for stabilization.
Jianquan Yan +9 more
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Quantitative Time-Dependent Variability and Independent Correlation of Eicosanoids in Human Plasma
, 2020 Purpose: Eicosanoids are small molecule lipid mediators of inflammation that, until recently, could not be measured in a high-throughput fashion or with high-resolution coverage.
Ovsak, Gavin
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Advanced Science, EarlyView.USP4 stabilizes CHAF1B by limiting K48‐linked ubiquitination. Stabilized CHAF1B supports UHRF1‐associated K63‐linked SETDB1 ubiquitination and cytoplasmic redistribution, whereas CHAF1B loss favors VHL‐dependent K11‐associated degradative ubiquitination and proteasomal loss of SETDB1.
Saiyan Bian +9 more
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Activation and Regulation of Cellular Eicosanoid Biosynthesis
The Scientific World Journal, 2007 There is a growing appreciation for the wide variety of physiological responses that are regulated by lipid messengers. One particular group of lipid messengers, the eicosanoids, plays a central role in regulating immune and inflammatory responses in a ...
Thomas G. Brock, Marc Peters-Golden
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Journal of Lipid Research, 2015 Cytochrome P450 (CYP)-dependent eicosanoids comprise epoxy- and hydroxy-metabolites of long-chain PUFAs (LC-PUFAs). In mammals, CYP eicosanoids contribute to the regulation of cardiovascular and renal function. Caenorhabditis elegans produces a large set
Yiwen Zhou +4 more
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, 2015 [[abstract]]Eicosanoids comprise a large array of small-molecular-weight compounds that are synthesized in almost all mammalian cells from an unsaturated fatty acid, arachidonic acid (AA), chemically known as eicosatetraenoic acid.
Wu, KK
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Advanced Science, EarlyView.Nuciferine directly binds the C2 domain of cPLA2, impairing its Ca2+‐dependent membrane translocation and activation. By suppressing arachidonic acid release and downstream pro‐inflammatory eicosanoid production, nuciferine attenuates NF‐κB signaling and inflammatory hepatocarcinogenesis, revealing cPLA2 as a direct molecular target underlying its ...
Jing Sun +12 more
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Animal Research and One Health, EarlyView.Selenomethionine can ameliorate arachidonic acid‐induced colonic injury through synergistic mechanisms, including alleviating inflammatory responses, improving barrier integrity, enhancing antioxidant capacity by upregulating selenoprotein expression, selectively regulating AA metabolism to reduce pro‐inflammatory oxylipins and promote the production ...
Huihui Tian +8 more
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