Results 1 to 10 of about 28,631 (145)
Role of Leukotrienes and Leukotriene Modifiers in Asthma
Pharmaceuticals, 2010 Leukotrienes (LTs), including cysteinyl LTs (CysLTs) and LTB4, are potent lipid mediators that are pivotal in the pathophysiology of asthma phenotypes. At least two receptor subtypes for CysLTs – CysLT1 and CysLT2 – have been identified.
Paolo Montuschi
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FIRST 5-DAYS FOLLOW-UP AND CORRELATION STUDY BETWEEN URINARY CYSTEINYL LEUKO TRIENES AND EDEMA VALUES IN PRIMARY SPONTANEOUS SUPRATENTORIAL INTRACEREBRAL HEMO RRHAGE [PDF]
Sanamed, 2014 Background: After intracerebral hemorrhage cysteinyl leukotrienes (C4, D4, E4) are synthetisized in the contact brain parenchyma-extravasated blood and participate in producing of edema formation.
Dolnenec-Baneva Natalia +3 more
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Leukotrienes vs. Montelukast—Activity, Metabolism, and Toxicity Hints for Repurposing
Pharmaceuticals, 2022 Increasing environmental distress is associated with a growing asthma incidence; no treatments are available but montelukast (MTK)—an antagonist of the cysteinyl leukotrienes receptor 1—is widely used in the management of symptoms among adults and ...
Cátia F. Marques +2 more
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Leukotrienes in Tumor-Associated Inflammation
Frontiers in Pharmacology, 2020 Leukotrienes are biologically active eicosanoid lipid mediators that originate from oxidative metabolism of arachidonic acid. Biosynthesis of leukotrienes involves a set of soluble and membrane-bound enzymes that constitute a machinery complex primarily ...
Wen Tian +10 more
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Montelukast induces beneficial behavioral outcomes and reduces inflammation in male and female rats
Frontiers in Immunology, 2022 BackgroundAccumulative data links inflammation and immune dysregulation to the pathophysiology of mental disorders; little is known regarding leukotrienes’ (LTs) involvement in this process.
Ira S. Rostevanov +8 more
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Plants, 2023 Arnica montana is well known for its anti-inflammatory properties. While the anti-inflammatory activity of Arnica flowers (Arnicae flos) has been extensively studied, that of the whole plant (Arnicae planta tota) is less characterized.
Johann Röhrl +8 more
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Leukotrienes, leukotriene receptor antagonists, and rhinitis [PDF]
Allergy, 2000 A series of clinical studies have shown the ef®cacy of leukotriene (LT) receptor antagonists (LTRAs) in the treatment of bronchial asthma (1±6). LTRAs relieve bronchospasm, prevent exercise-induced asthma, and reduce bronchial hyperresponsiveness.
N, Mygind, R, Dahl, H, Bisgaard
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Медицинская иммунология, 2022 Rhinitis is a socially significant and widespread disease. Often, various forms of rhinitis are combined, and thus cause severe clinical manifestations, insufficient effectiveness of drug treatment, as well as difficulties in differential diagnosis.
O. A. Kulikova +4 more
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Leukotriene mechanisms of allergic enterocolitis pathogenesis in young children
Zaporožskij Medicinskij Žurnal, 2018 Purpose of the study was to determine the parameters of lipid mediators of allergic inflammation (cysteinyl leukotrienes C4, D4, E4) by enzyme immunoassay in serum, saliva, urine of young children with allergic enterocolitis.Materials and methods.
O. H. Shadrin, H. A. Haiduchyk
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A Novel Strategy to Mitigate the Hyperinflammatory Response to COVID-19 by Targeting Leukotrienes
Frontiers in Pharmacology, 2020 SARS-CoV-2 causing coronavirus disease 2019 (COVID-19) has wreaked havoc during the global pandemic of 2020 infecting millions and leaving over a half million dead.
Colin D. Funk +2 more
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