Results 11 to 20 of about 35,647 (293)
Leukotrienes and Atherosclerosis
Current Drug Targets, 2010 Evidence from experimental and genetic studies suggest the existence of a potential link between the leukotrienes (LT) signalling cascade, and the pathogenesis/progression of atherosclerosis and its serious consequences such as acute myocardial infarction (AMI), stroke, aortic aneurysms, and intimal hyperplasia.
G. Riccioni, M. Bäck, V. Capra
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LEUKOTRIENES AND ANTILEUKOTRIENE DRUGS IN ALLERGIC RHINITIS
Педиатрическая фармакология, 2009 Allergic rhinitis is an allergic inflammation of the nasal mucosa due to sensitization to some inhalation allergens. There are two phases of a systemic allergic reaction depending on interaction of different cell types a biochemical mediators — the early
M.A. Zharkikh +2 more
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The role of leukotrienes in the pathogenesis of systemic sclerosis [PDF]
Folia Histochemica et Cytobiologica, 2012 Systemic sclerosis (SSc, scleroderma) is an autoimmune disease characterized by widespread vascular injury and progressive fibrosis of the skin and internal organs.
Sylwia Chwieśko-Minarowska +3 more
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Total synthesis of leukotrienes from butadiene
, 2000 The total synthesis of leukotrienes has been achieved starting from butadiene by a palladium-catalyzed telomerization at room temperature. A Sharpless catalytic asymmetric epoxidation generated the asymmetric centers with >94% ee, Simple ...
Nomen, M +4 more
core +5 more sources
Leukotrienes, leukotriene receptor antagonists, and rhinitis [PDF]
Allergy, 2000 A series of clinical studies have shown the ef®cacy of leukotriene (LT) receptor antagonists (LTRAs) in the treatment of bronchial asthma (1±6). LTRAs relieve bronchospasm, prevent exercise-induced asthma, and reduce bronchial hyperresponsiveness.
N, Mygind, R, Dahl, H, Bisgaard
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Addition to inhaled corticosteroids of long-acting beta2-agonists versus anti-leukotrienes for chronic asthma [PDF]
, 2011 Asthma patients who continue to experience symptoms despite being on regular inhaled corticosteroids (ICS) represent a management challenge. Long-acting beta2-agonists (LABA) or anti-leukotrienes (LTRA) are two treatment options that could be considered ...
Christopher J Cates +5 more
core +1 more source
Hepatology, EarlyView., 2022 Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario +12 more
wiley +1 more source
Hepatology, EarlyView., 2022 CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli +13 more
wiley +1 more source
Metabolism of Exogenous Leukotrienes by Cultured Human Keratinocytes [PDF]
, 1990 Leukotrienes are involved in diseases associated with a neutrophilic infiltrate. The role of human keratinocytes in the metabolism and inactivation of leukotrienes has not been thoroughly examined.
Lyons, M. Bradley +3 more
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Cytoplasmic lipid bodies in eosinophils: Central roles in eicosanoid generation
Allergology International, 1997 Lipid bodies are non-membrane bound, lipid-rich cytoplasmic inclusions that form in diverse cell types. Characteristically, lipid body numbers increase when eosinophils and other leukocytes are participating in inflammatory processes.
Peter F Weller +3 more
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