Results 11 to 20 of about 28,774 (254)

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Knock-In Mice Expressing a 15-Lipoxygenating Alox5 Mutant Respond Differently to Experimental Inflammation Than Reported Alox5^−/− Mice

Metabolites, 2021
Arachidonic acid 5-lipoxygenase (ALOX5) is the key enzyme in the biosynthesis of pro-inflammatory leukotrienes. We recently created knock-in mice (Alox5-KI) which express an arachidonic acid 15-lipoxygenating Alox5 mutant instead of the 5-lipoxygenating ...
Eugenia Marbach-Breitrück, Nadine Rohwer, Carmen Infante-Duarte, Silvina Romero-Suarez, Dominika Labuz, Halina Machelska, Laura Kutzner, Nils Helge Schebb, Michael Rothe, Pallu Reddanna, Karsten H. Weylandt, Lothar H. Wieler, Dagmar Heydeck, Hartmut Kuhn   +13 more
doaj   +1 more source

New Hydroxycinnamic Acid Esters as Novel 5-Lipoxygenase Inhibitors That Affect Leukotriene Biosynthesis

Mediators of Inflammation, 2017
Leukotrienes are inflammatory mediators that actively participate in the inflammatory response and host defense against pathogens. However, leukotrienes also participate in chronic inflammatory diseases. 5-lipoxygenase is a key enzyme in the biosynthesis
Luc H. Boudreau, Grégoire Lassalle-Claux, Marc Cormier, Sébastien Blanchard, Marco S. Doucet, Marc E. Surette, Mohamed Touaibia   +6 more
doaj   +1 more source

Cytoplasmic lipid bodies in eosinophils: Central roles in eicosanoid generation

Allergology International, 1997
Lipid bodies are non-membrane bound, lipid-rich cytoplasmic inclusions that form in diverse cell types. Characteristically, lipid body numbers increase when eosinophils and other leukocytes are participating in inflammatory processes.
Peter F Weller, Patricia T Bozza, Wengui Yu, Ann M Dvorak   +3 more
doaj   +1 more source

Contributions of mast cells and vasoactive products, leukotrienes and chymase, to dengue virus-induced vascular leakage

eLife, 2013
Dengue Virus (DENV), a flavivirus spread by mosquito vectors, can cause vascular leakage and hemorrhaging. However, the processes that underlie increased vascular permeability and pathological plasma leakage during viral hemorrhagic fevers are largely ...
Ashley L St John, Abhay PS Rathore, Bhuvanakantham Raghavan, Mah-Lee Ng, Soman N Abraham   +4 more
doaj   +1 more source

Integrated genomic, transcriptomic, and epigenetic analyses identify a leukotriene synthesis-related M2 macrophage gene signature that predicts prognosis and treatment vulnerability in gliomas

Frontiers in Immunology, 2022
The pathological implications of tumor-associated macrophages in the glioma microenvironment have been highlighted, while there lacks a gene signature to characterize the functional status and clinical implications of these cells.
Hang Ji, Hang Ji, Hang Ji, Zhihui Liu, Zhihui Liu, Nan Wang, Nan Wang, Jiaqi Jin, Jiaqi Jin, Jiheng Zhang, Jiheng Zhang, Jiawei Dong, Jiawei Dong, Fang Wang, Fang Wang, Xiuwei Yan, Xiuwei Yan, Qin Gong, Hongtao Zhao, Hongtao Zhao, Haogeng Sun, Yongzhe Li, Shaoshan Hu, Shaoshan Hu, Chao You   +24 more
doaj   +1 more source

Crosstalk between ORMDL3, serine palmitoyltransferase, and 5-lipoxygenase in the sphingolipid and eicosanoid metabolic pathways

Journal of Lipid Research, 2021
Leukotrienes (LTs) and sphingolipids are critical lipid mediators participating in numerous cellular signal transduction events and developing various disorders, such as bronchial hyperactivity leading to asthma. Enzymatic reactions initiating production
Viktor Bugajev, Tomas Paulenda, Pavol Utekal, Michal Mrkacek, Ivana Halova, Ladislav Kuchar, Ondrej Kuda, Petra Vavrova, Björn Schuster, Sergio Fuentes-Liso, Lucie Potuckova, Daniel Smrz, Sara Cernohouzova, Lubica Draberova, Monika Bambouskova, Petr Draber   +15 more
doaj   +1 more source

NSAIDs and Acute Pancreatitis: A Systematic Review

Pharmaceuticals, 2010
The resulting pain is the main symptom of acute pancreatitis and it should be alleviated as soon as possible. NSAIDs are the first line therapy for pain and they are generally administered to acute pancreatitis patients upon admission to the hospital. In
Roberto Corinaldesi, Antonio Maria Morselli-Labate, Raffaele Pezzilli   +2 more
doaj   +1 more source

Differential impact of 5-lipoxygenase-activating protein antagonists on the biosynthesis of leukotrienes and of specialized pro-resolving mediators

Frontiers in Pharmacology, 2023
Lipoxygenases (LOX) transform arachidonic acid (AA, C20:4) and docosahexaenoic acid (DHA, C22:6) into bioactive lipid mediators (LMs) that comprise not only pro-inflammatory leukotrienes (LTs) but also the specialized pro-resolving mediators (SPMs) that ...
Philipp Dahlke, Lukas K. Peltner, Paul M. Jordan, Paul M. Jordan, Oliver Werz, Oliver Werz   +5 more
doaj   +1 more source