Results 21 to 30 of about 28,631 (145)

High intake of n-6 polyunsaturated fatty acid exacerbates non-alcoholic steatohepatitis by the involvement of multiple metabolic pathways

Frontiers in Nutrition
Non-alcoholic steatohepatitis (NASH) is characterized by steatosis, inflammation, and hepatocyte damage. A Western-style diet characterized by excessive n-6 polyunsaturated fatty acid (n-6 PUFA) intake, which is metabolized to pro-inflammatory ...
Jian-Tong, Meng-Ting Zhou, Xiang-Zhun Song, Liu Yang, Yu-Hui Fang, Lan Liu, Jing-Shu Cui, Xiao-Chen Lu, Hai-Yang Zhu, Ying-Bin Jin, Hong-Mei Han   +10 more
doaj   +1 more source

The role of leukotrienes in the pathogenesis of systemic sclerosis

Folia Histochemica et Cytobiologica, 2012
Systemic sclerosis (SSc, scleroderma) is an autoimmune disease characterized by widespread vascular injury and progressive fibrosis of the skin and internal organs.
Sylwia Chwieśko-Minarowska, Krzysztof Kowal, Marek Bielecki, Otylia Kowal-Bielecka   +3 more
doaj   +1 more source

Cytokine-Leukotriene Receptor Interactions

The Scientific World Journal, 2007
Biochemical and pharmacological studies have identified the structure of leukotrienes, the pathways that lead to their synthesis, and the signaling events they trigger when they interact with their cognate receptors.
Marek Rola-Pleszczynski, Jana Stankova
doaj   +1 more source

LTB4 and 5-oxo-ETE from extracellular vesicles stimulate neutrophils in granulomatosis with polyangiitis

Journal of Lipid Research, 2020
Activation of neutrophils is an important mechanism in the pathology of granulomatosis with polyangiitis (GPA). In this study, we evaluated whether extracellular vesicles (EVs) circulating in the plasma of GPA patients could contribute to this process ...
Marcin Surmiak, Anna Gielicz, Darko Stojkov, Rafał Szatanek, Katarzyna Wawrzycka-Adamczyk, Shida Yousefi, Hans-Uwe Simon, Marek Sanak   +7 more
doaj   +1 more source

Cytosolic phospholipase A2: physiological function and role in disease

Journal of Lipid Research, 2015
The group IV phospholipase A2 (PLA2) family is comprised of six intracellular enzymes (GIVA, -B, -C, -D, -E, and -F) commonly referred to as cytosolic PLA2 (cPLA2)α, -β, -γ, -δ, -ε, and -ζ. They contain a Ser-Asp catalytic dyad and all except cPLA2γ have
Christina C. Leslie
doaj   +1 more source

Adipose triglyceride lipase regulates eicosanoid production in activated human mast cells

Journal of Lipid Research, 2014
Human mast cells (MCs) contain TG-rich cytoplasmic lipid droplets (LDs) with high arachidonic acid (AA) content. Here, we investigated the functional role of adipose TG lipase (ATGL) in TG hydrolysis and the ensuing release of AA as substrate for ...
Andrea Dichlberger, Stefanie Schlager, Katariina Maaninka, Wolfgang J. Schneider, Petri T. Kovanen   +4 more
doaj   +1 more source

Leukotrienes are not essential for the efficacy of a heterologous vaccine against Mycobacterium tuberculosis infection

Brazilian Journal of Medical and Biological Research, 2010
Leukotrienes are reported to be potent proinflammatory mediators that play a role in the development of several inflammatory diseases such as asthma, rheumatoid arthritis and periodontal disease.
L.H. Franco, M. Oliveira e Paula, P.F. Wowk, D.M. da Fonseca, C.A. Sérgio, P.F. Fedatto, A.F. Gembre, S.G. Ramos, C.L. Silva, A.I. Medeiros, L.H. Faccioli, V.L.D. Bonato   +11 more
doaj  

Leukemoid like reaction in a post CABG patient

Indian Journal of Anaesthesia, 2014
The presentation of leukemoid reaction in patients post-cardiac surgery is rare with limited prior reports in the English language literature. We report a case of raised leukocyte count with no evidence of infection in a patient post coronary artery ...
G Padmakumar, J Ravikrishnan, P Jayakumar, K Prasad   +3 more
doaj   +1 more source

BRONCHIAL OBSTRUCTION IN CHILDREN: A NEW SOLUTION TO AN OLD PROBLEM

Вопросы современной педиатрии, 2015
Bronchial obstruction is a widespread pathological condition in children. The development of this syndrome in bronchial asthma is caused by an allergic inflammation of the mucous membranes of the respiratory tract with the participation of leukotrienes ...
O. I. Simonova, Yu. V. Gorinova, A. A. Alekseeva, A. A. Tomilova   +3 more
doaj   +1 more source

The Potential of Telomeric G-Quadruplexes Containing Modified Oligoguanosine Overhangs in Activation of Bacterial Phagocytosis and Leukotriene Synthesis in Human Neutrophils

Biomolecules, 2020
Human neutrophils are the first line of defense against bacterial and viral infections. They eliminate pathogens through phagocytosis, which activate the 5-lipoxygenase (5-LOX) pathway resulting in synthesis of leukotrienes.
Ekaterina A. Golenkina, Galina M. Viryasova, Nina G. Dolinnaya, Valeria A. Bannikova, Tatjana V. Gaponova, Yulia M. Romanova, Galina F. Sud’ina   +6 more
doaj   +1 more source