Results 1 to 10 of about 29,365 (204)

Structural basis of leukotriene B4 receptor 1 activation [PDF]

Nature Communications, 2022
In the paper, Dr. Wang et al reported a cryo-EM structure of the human leukotriene B4 receptor 1 (BLT1) in complex with its native ligand leukotriene B4 (LTB4) in an active conformation complexed with Gi protein.
Na Wang, Xinheng He, Jing Zhao, Hualiang Jiang, Xi Cheng, Yu Xia, H. Eric Xu, Yuanzheng He   +7 more
doaj   +2 more sources

The role of leukotriene B4 in cow metritis [PDF]

Journal of Veterinary Research, 2023
Metritis is a common postpartum disease in dairy cows. As a mast cell (MC) mediator, leukotriene B4 (LTB4) is the strongest phagocyte chemokine. It is important in inflammation for the recruitment of immune cells to resist infection.
Wang Guo-Qing, Zheng Hao-Yue, Hou Jin-Long, Wang Cui, Sun Hui-Lian, Wang Lan   +5 more
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Elevated leukotriene B4 and 8-isoprostane in exhaled breath condensate from preterm-born infants [PDF]

BMC Pediatrics, 2023
Background Inflammation and oxidative stress play a key role in the development of bronchopulmonary dysplasia (BPD), possibly contributing to persistent respiratory morbidity after preterm birth.
Rhea Urs, Rubi Ni Chin, Naomi Hemy, Andrew C. Wilson, J. Jane Pillow, Graham L. Hall, Shannon J. Simpson   +6 more
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Circulating Leukotriene B4 Identifies Respiratory Complications after Trauma [PDF]

Mediators of Inflammation, 2012
Background. Leukotriene B4 (LTB4), a proinflammatory lipid mediator correlates well with the acute phase of Acute Respiratory Distress Syndrome (ARDS). Therefore, LTB4-levels were investigated to determine whether they might be a useful clinical marker ...
Birgit Auner, Emanuel V. Geiger, Dirk Henrich, Mark Lehnert, Ingo Marzi, Borna Relja   +5 more
doaj   +2 more sources

Structural insights on ligand recognition at the human leukotriene B4 receptor 1 [PDF]

Nature Communications, 2021
Human leukotriene B4 receptors (BLT1 and BLT2) are members of the GPCR superfamily that respond to a potent pro-inflammatory lipid and chemoattractant LTB4.
Nairie Michaelian, Anastasiia Sadybekov, Élie Besserer-Offroy, Gye Won Han, Harini Krishnamurthy, Beata A. Zamlynny, Xavier Fradera, Phieng Siliphaivanh, Jeremy Presland, Kerrie B. Spencer, Stephen M. Soisson, Petr Popov, Philippe Sarret, Vsevolod Katritch, Vadim Cherezov   +14 more
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Fluorescent leukotriene B4: potential applications [PDF]

Journal of Lipid Research, 2005
Leukotriene B4 (LTB4) is a potent lipid mediator of inflammation that acts primarily via a seven-transmembrane-spanning, G-protein-coupled receptor denoted BLT1. Here, we describe the synthesis and characterization of fluorescent analogs of LTB4 that are
Alan Sabirsh, Anders Wetterholm, Jesper Bristulf, Hakon Leffler, Jesper Z. Haeggström, Christer Owman   +5 more
doaj   +3 more sources

ATP and Formyl Peptides Facilitate Chemoattractant Leukotriene-B4 Synthesis and Drive Calcium Fluxes, Which May Contribute to Neutrophil Swarming at Sites of Cell Damage and Pathogens Invasion [PDF]

Biomedicines
Here, we demonstrate that human neutrophil interaction with the bacterium Salmonella typhimurium fuels leukotriene B4 synthesis induced by the chemoattractant fMLP.
Ekaterina A. Golenkina, Galina M. Viryasova, Svetlana I. Galkina, Iuliia V. Iakushkina, Tatjana V. Gaponova, Yulia M. Romanova, Galina F. Sud’ina   +6 more
doaj   +2 more sources

Sulfur compounds navigate redox processes, leukotriene synthesis, and ω-hydroxylation of leukotriene B4 in neutrophil interaction with the bacteria Salmonella typhimurium: the way to manipulate neutrophil swarming [PDF]

Frontiers in Immunology
Neutrophils are the first immune cells recruited by invading pathogens. During interaction with bacteria, neutrophils synthesize leukotriene B4, a potent chemoattractant that, in conjunction with the primary bacterial chemoattractant N-formyl-l-methionyl-
Ekaterina A. Golenkina, Sofia V. Navarnova, Galina M. Viryasova, Svetlana I. Galkina, Tatjana V. Gaponova, Yulia M. Romanova, Galina F. Sud’ina   +6 more
doaj   +2 more sources

Neutrophil recruitment depends on platelet-derived leukotriene B4 [PDF]

Blood Advances
Christian Hackenbroch, Tugce Cimen, Carina Gross, Stefanie Rubenzucker, Philipp Burkard, Niklas Groß, Robert Ahrends, Tamara Girbl, David Stegner   +8 more
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High leukotriene B4 serum levels increase risk of painful diabetic neuropathy among type 2 diabetes mellitus patients

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2021
Background Painful diabetic neuropathy is one of the most common complications of type 2 diabetes mellitus, with approximately 30–50% of people will experience diabetic neuropathy.
Kelvin Yuwanda, I Putu Eka Widyadharma, Dewa Putu Gde Purwa Samatra, I Made Oka Adnyana, Anna Marita Gelgel, I Komang Arimbawa   +5 more
doaj   +1 more source