Results 1 to 10 of about 486,846 (263)

Conquering Neutrophils. [PDF]

PLoS Pathogens, 2016
Simon Döhrmann, Jason N Cole, Victor Nizet   +2 more
doaj   +7 more sources

Generation of resolving memory neutrophils through pharmacological training with 4-PBA or genetic deletion of TRAM

Cell Death and Disease, 2022
Neutrophils are the dominant leukocytes in circulation and the first responders to infection and inflammatory cues. While the roles of neutrophils in driving inflammation have been widely recognized, the contribution of neutrophils in facilitating ...
RuiCi Lin, Ziyue Yi, Jing Wang, Shuo Geng, Liwu Li   +4 more
doaj   +1 more source

The Age-Driven Decline in Neutrophil Function Contributes to the Reduced Efficacy of the Pneumococcal Conjugate Vaccine in Old Hosts

Frontiers in Cellular and Infection Microbiology, 2022
Despite the availability of vaccines, Streptococcus pneumoniae (pneumococcus) remains a serious cause of infections in the elderly. The efficacy of anti-pneumococcal vaccines declines with age.
Shaunna R. Simmons, Essi Y. I. Tchalla, Manmeet Bhalla, Elsa N. Bou Ghanem   +3 more
doaj   +1 more source

Neutrophils isolated from systemic lupus erythematosus patients exhibit a distinct functional phenotype

Frontiers in Immunology
Neutrophil dysregulation, particularly of a low-density subset, is associated with systemic lupus erythematosus (SLE); however, the exact role of normal-density neutrophils in SLE remains unknown.
Neelakshi R. Jog, Catriona A. Wagner, Teresa Aberle, Eliza F. Chakravarty, Cristina Arriens, Joel M. Guthridge, Judith A. James, Judith A. James   +7 more
doaj   +1 more source

ATRA treatment slowed P-selectin-mediated rolling of flowing HL60 cells in a mechano-chemical-dependent manner

Frontiers in Immunology, 2023
All-trans retinoic acid (ATRA)-induced differentiation of acute promyelocytic leukemia (APL) toward granulocytes may trigger APL differentiation syndrome (DS), but there is less knowledge about the mechano-chemical regulation mechanism of APL DS under ...
Xiaoting Dong, Shiping Peng, Yingchen Ling, Bing Huang, Bing Huang, Wenjian Tu, Xiaoxi Sun, Quhuan Li, Ying Fang, Jianhua Wu   +9 more
doaj   +1 more source

Neutrophils cultured ex vivo from CD34+ stem cells are immature and genetically tractable

Journal of Translational Medicine
Background Neutrophils are granulocytes with essential antimicrobial effector functions and short lifespans. During infection or sterile inflammation, emergency granulopoiesis leads to release of immature neutrophils from the bone marrow, serving to ...
Claire A. Naveh, Kiran Roberts, Przemysław Zakrzewski, Christopher M. Rice, Fernando M. Ponce-Garcia, Kathryn Fleming, Megan Thompson, Nawamin Panyapiean, Huan Jiang, Stephanie Diezmann, Pedro L. Moura, Ashley M. Toye, Borko Amulic   +12 more
doaj   +1 more source

Pro-inflammatory role of neutrophils populations in trauma patients: monitoring neutrophil populations

Frontiers in Immunology
BackgroundTrauma is a leading global cause of mortality, and systemic inflammatory response syndrome (SIRS) remains a significant complication, contributing to adverse outcomes.
Marcela Vlková, Marcela Vlková, Julie Štíchová, Julie Štíchová, Karolína Surá, Karolína Surá, Karolína Dvořáková, Karolína Dvořáková, Vojtěch Kunčický, Vojtěch Kunčický, Ioanna Papatheodorou, Ioanna Papatheodorou, Gabriela Blažková, Zuzana Tomášiková, Zuzana Tomášiková, Kamila Bendíčková, Kamila Bendíčková, Ludmila Dohnálková, Alexandra Mýtniková, Alexandra Mýtniková, Alexandra Mýtniková, Jan Žák, Jan Kovařík, Milan Krtička, Tomáš Tomáš, Vladimír Šrámek, Martin Helán, Martin Helán, Anna Kocurková, Anna Kocurková, Anna Kocurková, Jan Frič, Jan Frič, Jan Frič, Marcela Hortová-Kohoutková, Marcela Hortová-Kohoutková   +35 more
doaj   +1 more source

Intratumoral CXCR4hi neutrophils display ferroptotic and immunosuppressive signatures in hepatoblastoma

Frontiers in Immunology
Pediatric hepatoblastoma (HB) is the most common primary liver malignancy in infants and children. With great diversity and plasticity, tumor-infiltrating neutrophils were one of the most determining factors for poor prognosis in many malignant tumors ...
Zhengjing Lu, Zhengjing Lu, Xiaolin Wang, Xiaolin Wang, Jun Feng, Wenjia Chai, Wenjia Chai, Wei Wang, Wei Wang, Qixin Wang, Qixin Wang, Shen Yang, Wei Yang, Yan Su, Wenjun Mou, Wenjun Mou, Yun Peng, Yun Peng, Huanmin Wang, Jingang Gui, Jingang Gui   +20 more
doaj   +1 more source

Proinflammatory Stimuli Enhance Phagocytosis of Apoptotic Cells by Neutrophil Granulocytes

The Scientific World Journal, 2011
Recently, we have reported that, in addition to macrophages, also neutrophil granulocytes can phagocytose apoptotic neutrophils. Based on this finding, we hypothesized that “cannibalistic” neutrophils at sites of acute infection/inflammation play a major
Lars Hellberg, Sabrina Fuchs, Christoph Gericke, Arup Sarkar, Martina Behnen, Werner Solbach, Tamás Laskay   +6 more
doaj   +1 more source

Changes in some Blood Micronutrients, Leukocytes and Neutrophil Expression of Adhesion Molecules in Periparturient Dairy Cows

Acta Veterinaria Scandinavica, 2001
Dairy cows are highly susceptible to infectious diseases, like mastitis, during the period around calving. Although factors contributing to increased susceptibility to infection have not been fully elucidated, impaired neutrophil recruitment to the site
Petersson L, Johannisson A, Meglia GE, Waller K Persson   +3 more
doaj   +1 more source