Results 21 to 30 of about 761,815 (305)

Neutrophils Lose the Capacity to Suppress T Cell Proliferation Upon Migration Towards Inflamed Joints in Juvenile Idiopathic Arthritis

Frontiers in Immunology, 2022
Neutrophils are highly abundant in synovial fluid of rheumatic inflamed joints. In oligoarticular juvenile idiopathic arthritis (JIA), synovial fluid neutrophils have impaired effector functions and altered phenotype.
Sabine Arve-Butler, Sabine Arve-Butler, Anki Mossberg, Anki Mossberg, Tobias Schmidt, Tobias Schmidt, Charlotte Welinder, Hong Yan, Elisabet Berthold, Elisabet Berthold, Petra Król, Robin Kahn, Robin Kahn   +12 more
doaj   +1 more source

Mesenchymal stem cells shift the pro-inflammatory phenotype of neutrophils to ameliorate acute lung injury

Stem Cell Research & Therapy, 2023
Background Mesenchymal stem cell (MSC) treatment plays a major role in the management of acute lung injury (ALI), and neutrophils are the initial line of defense against ALI.
Bing Feng, Xudong Feng, Yingduo Yu, Haoying Xu, Qingqing Ye, Ruitian Hu, Xinru Fang, Feiqiong Gao, Jian Wu, Qiaoling Pan, Jiong Yu, Guanjing Lang, Lanjuan Li, Hongcui Cao   +13 more
doaj   +1 more source

Neutrophil extracellular traps released by neutrophils impair revascularization and vascular remodeling after stroke

Nature Communications, 2020
Neovascularization and vascular remodeling are functionally important for brain repair after stroke. We show that neutrophils accumulate in the peri-infarct cortex during all stages of ischemic stroke.
Lijing Kang, Huilin Yu, Xing Yang, Yuanbo Zhu, Xiaofei Bai, Ranran Wang, Yongliang Cao, Haochen Xu, Haiyu Luo, Lu Lu, Mei-Juan Shi, Yujing Tian, Wenying Fan, Bing-Qiao Zhao   +13 more
semanticscholar   +1 more source

The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments

Nature Communications, 2021
Neutrophils are implicated in multiple homeostatic and pathological processes, but whether functional diversity requires discrete neutrophil subsets is not known.
Ricardo Grieshaber-Bouyer, Felix A. Radtke, P. Cunin, Giuseppina Stifano, A. Levescot, B. Vijaykumar, Nathan P Nelson-Maney, Rachel B. Blaustein, P. Monach, P. Nigrovic, Oscar Rhys Jilian K. Frank Nora Alev Christophe Brian D. Aguilar Allan Astarita Austen Barrett Baysoy Benoi, Oscar Aguilar, R. Allan, Jilian Astarita, K. Austen, N. Barrett, Alev Baysoy, C. Benoist, Brian D. Brown, M. Buechler, Jason D. Buenrostro, M. A. Casanova, Kaitavjeet Chowdhary, M. Colonna, T. Crowl, Tianda Z. Deng, Fiona A. Desland, Maxime Dhainaut, Jiarui Ding, C. Dominguez, D. Dwyer, Michela Frascoli, S. Gal-Oz, Ananda W. Goldrath, Timothy M. Johanson, Stefan Jordan, Joonsoo Kang, V. Kapoor, E. Kenigsberg, Joel Kim, K. Kim, Evgeny Kiner, M. Kronenberg, Lewis L Lanier, C. Laplace, C. Lareau, A. Leader, Jisu Lee, Assaf Magen, B. Maier, Alexandra Maslova, D. Mathis, Adelle P. McFarland, M. Merad, E. Meunier, Sara Mostafavi, S. Muller, C. Muus, Hadas Ner-Gaon, Quyhn Nguyen, German Novakovsky, S. Nutt, Kayla Omilusik, A. Ortíz-López, Mallory L. Paynich, Vincent Peng, Marc Potempa, R. Pradhan, Sara Quon, R. Ramirez, D. Ramanan, G. Randolph, A. Regev, Samuel A. Rose, Kumba Seddu, T. Shay, A. Shemesh, J. Shyer, Christopher Smilie, Nicholas A Spidale, Ayshwarya Subramanian, Katelyn E. Sylvia, Julie Tellier, S. Turley, B. Vijaykumar, A. Wagers, Chendi Wang, Peter L. Wang, A. Wróblewska, Liang Yang, Aldrin K. Yim, H. Yoshida   +91 more
semanticscholar   +1 more source

Neutrophils: New Critical Regulators of Glioma

Frontiers in Immunology, 2022
In cancer, neutrophils are an important part of the tumour microenvironment (TME). Previous studies have shown that circulating and infiltrating neutrophils are associated with malignant progression and immunosuppression in gliomas.
Guanyu Wang, Jinpeng Wang, Chaoshi Niu, Chaoshi Niu, Chaoshi Niu, Chaoshi Niu, Yan Zhao, Pengfei Wu, Pengfei Wu, Pengfei Wu, Pengfei Wu, Pengfei Wu   +11 more
doaj   +1 more source

Understanding the Multifaceted Role of Neutrophils in Cancer and Autoimmune Diseases

Frontiers in Immunology, 2018
Neutrophils are one of the first immune cell types that are recruited to injury and infection site. As a vital component of the immune system, neutrophils are heterogeneous immune cells known to have phagocytic property and function in inflammation ...
Xu Wang, Xu Wang, Xu Wang, Xu Wang, Lin Qiu, Lin Qiu, Lin Qiu, Lin Qiu, Ziyi Li, Ziyi Li, Xiang-Yang Wang, Xiang-Yang Wang, Huanfa Yi, Huanfa Yi, Huanfa Yi   +14 more
doaj   +1 more source

Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19

Nature Medicine, 2021
Although critical for host defense, innate immune cells are also pathologic drivers of acute respiratory distress syndrome (ARDS). Innate immune dynamics during Coronavirus Disease 2019 (COVID-19) ARDS, compared to ARDS from other respiratory pathogens ...
S. Sinha, Nicole L. Rosin, R. Arora, E. Labit, A. Jaffer, L. Cao, Raquel Farias, Angela P. Nguyen, Luiz G. N. de Almeida, A. Dufour, A. Bromley, B. McDonald, M. Gillrie, M. Fritzler, B. Yipp, J. Biernaskie   +15 more
semanticscholar   +1 more source

Comparison of Neutrophil Function in Granulocyte Concentrates From Prednisone- and G-CSF-Treated Donors: Effect of Stimulant, Leukapheresis and Storage

Frontiers in Medicine, 2022
Transfusion of granulocyte concentrates (GC) is an alternative therapy for neutropenic patients with life-threatening infections. While neutrophils are the main source of antimicrobial activity, only neutrophil numbers are used to certify GCs.
Andréa Murru, Andréa Murru, Andréa Murru, Marie-Ève Allard, Guillaume Paré, Guillaume Paré, Myriam Vaillancourt, Myriam Vaillancourt, Lucie Boyer, Marie-Pierre Cayer, Julien Vitry, Julien Vitry, Patricia Landry, Marie-Michèle Labrecque, Marie-Michèle Labrecque, Nancy Robitaille, Donald R. Branch, Mélissa Girard, Maria J. Fernandes, Maria J. Fernandes   +19 more
doaj   +1 more source

Neutrophils contribute to elevated BAFF levels to modulate adaptive immunity in patients with primary immune thrombocytopenia by CD62P and PSGL1 interaction

Clinical & Translational Immunology, 2022
Objectives Immune thrombocytopenia (ITP) is an autoimmune disease characterised by impaired platelet production and increased platelet destruction. However, the involvement of neutrophils in ITP is yet to be explored.
Pengcheng Xu, Xia Shao, Yang Ou, Yanxia Zhan, Lili Ji, Xibing Zhuang, Ying Li, Yanna Ma, Duojiao Wu, Tiankui Qiao, Xiangdong Wang, Hao Chen, Yunfeng Cheng   +12 more
doaj   +1 more source

Neutrophils Kill Reactive Oxygen Species-Resistant Pseudomonas aeruginosa by Sphingosine

Cellular Physiology and Biochemistry, 2017
Background/Aims: Cystic fibrosis (CF) is dominated by chronic inflammation and infection of the lung resulting in lung destruction and early death of patients. The lungs of CF patients are characterized by a massive accumulation of neutrophils.
Katrin Anne Becker, Xiang Li, Aaron Seitz, Joerg Steinmann, Anne Koch, Edward Schuchman, Markus Kamler, Michael J. Edwards, Charles C.  Caldwell, Erich Gulbins   +9 more
doaj   +1 more source