Results 21 to 30 of about 571,123 (210)

Gap-junctional coupling between neutrophils and endothelial cells [PDF]

, 2003
Communication between leukocytes and endothelial cells is crucial for inflammatory reactions. Paracrine cross-talk and outside-in signaling (via adhesion molecules) have been characterized as communication pathways to date.
Gloe, Torsten, Hoffmann, Anke, Pohl, Ulrich, Zahler, Stefan   +3 more
core   +1 more source

Molsidomine inhibits the chemoattractant-induced respiratory burst in human neutrophils via a no-independent mechanism [PDF]

, 1992
3-Morpholino-sydnonimine (SIN-1) is a NO-releasing compound which mimics the effects of cGMP through activation of soluble guanylyl cyclase. Its prodrug, molsidomine (SIN-10), does not release NO but does modulate various cell functions.
Seifert, Roland, Jürgen Ervens, Roland Seifert, Ervens, J.   +3 more
core   +1 more source

Alkalinity of Neutrophil Phagocytic Vacuoles Is Modulated by HVCN1 and Has Consequences for Myeloperoxidase Activity. [PDF]

, 2015
The NADPH oxidase of neutrophils, essential for innate immunity, passes electrons across the phagocytic membrane to form superoxide in the phagocytic vacuole.
Adam P Levine, Michael R Duchen, Peter R. Rich, Anthony W. Segal, Adam P. Levine, de Villiers, S, Anthony W Segal, Simon de Villiers (725764), Peter R. Rich (725765), Michael R. Duchen (49273), Peter R Rich, Levine, AP, Duchen, MR, Simon de Villiers, Michael R. Duchen, Rich, PR, Adam P. Levine (473969), Anthony W. Segal (251124), Segal, AW   +18 more
core   +1 more source

Neutrophils Kill Reactive Oxygen Species-Resistant Pseudomonas aeruginosa by Sphingosine

Cellular Physiology and Biochemistry, 2017
Background/Aims: Cystic fibrosis (CF) is dominated by chronic inflammation and infection of the lung resulting in lung destruction and early death of patients. The lungs of CF patients are characterized by a massive accumulation of neutrophils.
Katrin Anne Becker, Xiang Li, Aaron Seitz, Joerg Steinmann, Anne Koch, Edward Schuchman, Markus Kamler, Michael J. Edwards, Charles C.  Caldwell, Erich Gulbins   +9 more
doaj   +1 more source

A role for Syk-kinase in the control of the binding cycle of the β2 integrins (CD11/CD18) in human polymorphonuclear neutrophils [PDF]

, 2003
A fine control of β2 integrin (CD11/CD18)-mediated firm adhesion of human neutrophils to the endothelial cell monolayer is required to allow ordered emigration.
Walzog, Barbara, Prange, Peggy, Willeke, Thomas, Zahler, Stefan, Schymeinsky, Jürgen   +4 more
core   +1 more source

Trans-basement membrane migration of eosinophils induced by LPS-stimulated neutrophils from human peripheral blood in vitro

ERJ Open Research, 2015
In the airways of severe asthmatics, an increase of neutrophils and eosinophils is often observed despite high-dose corticosteroid therapy. We previously reported that interleukin-8-stimulated neutrophils induced trans-basement membrane migration (TBM ...
Fuyumi Nishihara, Kazuyuki Nakagome, Takehito Kobayashi, Toru Noguchi, Ryuichiro Araki, Yoshitaka Uchida, Tomoyuki Soma, Makoto Nagata   +7 more
doaj   +1 more source

Comparison of Neutrophil Function in Granulocyte Concentrates From Prednisone- and G-CSF-Treated Donors: Effect of Stimulant, Leukapheresis and Storage

Frontiers in Medicine, 2022
Transfusion of granulocyte concentrates (GC) is an alternative therapy for neutropenic patients with life-threatening infections. While neutrophils are the main source of antimicrobial activity, only neutrophil numbers are used to certify GCs.
Andréa Murru, Andréa Murru, Andréa Murru, Marie-Ève Allard, Guillaume Paré, Guillaume Paré, Myriam Vaillancourt, Myriam Vaillancourt, Lucie Boyer, Marie-Pierre Cayer, Julien Vitry, Julien Vitry, Patricia Landry, Marie-Michèle Labrecque, Marie-Michèle Labrecque, Nancy Robitaille, Donald R. Branch, Mélissa Girard, Maria J. Fernandes, Maria J. Fernandes   +19 more
doaj   +1 more source

The proangiogenic capacity of polymorphonuclear neutrophils delineated by microarray technique and by measurement of neovascularization in wounded skin of CD18-deficient mice [PDF]

, 2006
Growing evidence supports the concept that polymorphonuclear neutrophils (PMN) are critically involved in inflammation-mediated angiogenesis which is important for wound healing and repair.
Scharffetter-Kochanek, K., Schruefer, R., Sulyok, S., Walzog, B., Peters, T., Schymeinsky, J.   +5 more
core   +1 more source

Phagocytosis of aged human neutrophils by macrophages is mediated by a novel "charge-sensitive" recognition mechanism [PDF]

, 1989
The removal of neutrophils and their histotoxic contents from the inflamed site is a prerequisite for resolution of tissue injury, and a point at which factors critical to the pathogenesis of chronic inflammation may act.
Savill, John S, J S Savill, Henson, P M, P M Henson, C Haslett, Haslett, Christopher   +5 more
core   +1 more source

Characterization of Neutrophil Function in Human Cutaneous Leishmaniasis Caused by Leishmania braziliensis. [PDF]

PLoS Neglected Tropical Diseases, 2016
Infection with different Leishmania spp. protozoa can lead to a variety of clinical syndromes associated in many cases with inflammatory responses in the skin.
Jacilara Conceição, Richard Davis, Pedro Paulo Carneiro, Angela Giudice, Aline C Muniz, Mary E Wilson, Edgar M Carvalho, Olívia Bacellar   +7 more
doaj   +1 more source