Results 41 to 50 of about 761,815 (305)

Deterministic reprogramming of neutrophils within tumors

Science
Neutrophils are increasingly recognized as key players in the tumor immune response and are associated with poor clinical outcomes. Despite recent advances characterizing the diversity of neutrophil states in cancer, common trajectories and mechanisms ...
M. Ng, I. Kwok, Leonard Tan, Changming Shi, Daniela Cerezo-Wallis, Yingrou Tan, K. Leong, Gabriel F. Calvo, Katharine Yang, Yuning Zhang, Jingsi Jin, K. Liong, Dandan Wu, Rui He, Dehua Liu, Ye Chean Teh, Camille Blériot, N. Caronni, Zhaoyuan Liu, Kaibo Duan, V. Narang, Iván Ballesteros, F. Moalli, Mengwei Li, Jinmiao Chen, Yao Liu, Lianxin Liu, Jingjing Qi, Yingbin Liu, Lingxi Jiang, Baiyong Shen, Hui Cheng, T. Cheng, Veronique Angeli, Ankur Sharma, Y. Loh, H. Tey, Shu Zhen Chong, M. Iannacone, R. Ostuni, Andrés Hidalgo, F. Ginhoux, L. Ng   +42 more
semanticscholar   +1 more source

Innate immune response in bovine neutrophils stimulated with Mycoplasma bovis

Veterinary Research, 2021
Mycoplasma bovis (M. bovis) is a significant worldwide pathogen of cattle. Neutrophils have an important role in the innate immune response during infection with M. bovis. However, even though neutrophils accumulate in M. bovis infection, the interaction
Satoshi Gondaira, Koji Nishi, Jumpei Fujiki, Hidetomo Iwano, Reina Watanabe, Ayako Eguchi, Yuki Hirano, Hidetoshi Higuchi, Hajime Nagahata   +8 more
doaj   +1 more source

Neutrophils and NETs in modulating acute and chronic inflammation.

Blood, 2019
Neutrophils are an absolutely essential part of the innate immune system, playing an essential role in the control of infectious diseases but more recently are also being viewed as important players in tissue repair. Neutrophils are able to counteract an
Fernanda V S Castanheira, P. Kubes
semanticscholar   +1 more source

Mineral trioxide aggregate induces the release of matrix metalloproteinase-9 by human neutrophils

Journal of Dental Sciences, 2013
Background/purpose: As a pulp capping agent, mineral trioxide aggregate (MTA) is commonly applied on inflamed tissues that present with a variety of immunocompetent cells, including neutrophils. Neutrophils are a major source of matrix metalloproteinases
Ya-Yun Lee, Yu-Chung Li, Shan-Ling Hung, Yi-Chen Chen, Yuan-Ho Lee, Shue-Fen Yang   +5 more
doaj   +1 more source

Excessive Neutrophils and Neutrophil Extracellular Traps in COVID-19

Frontiers in Immunology, 2020
Background: Cases of excessive neutrophil counts in the blood in severe coronavirus disease (COVID-19) patients have drawn significant attention. Neutrophil infiltration was also noted on the pathological findings from autopsies.
Jun Wang, Qian Li, Yongmei Yin, Yingying Zhang, Yingying Cao, Xiaomin Lin, Lihua Huang, D. Hoffmann, Mengji Lu, Yuanwang Qiu   +9 more
semanticscholar   +1 more source

Neutrophil microRNAs

Biological Reviews, 2023
ABSTRACTNeutrophils are considered ‘first‐line defence’ cells as they can be rapidly recruited to the site of the immune response. As key components of non‐specific immune mechanisms, neutrophils use phagocytosis, degranulation, and formation of neutrophil extracellular traps (NETs) to fight pathogens.
Marzena Garley, Karolina Nowak, Ewa Jabłońska   +2 more
openaire   +3 more sources

Fatty acid transporter 2 reprograms neutrophils in cancer

Nature, 2019
Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) are pathologically activated neutrophils that are crucial for the regulation of immune responses in cancer.
F. Veglia, V. Tyurin, M. Blasi, Alessandra De Leo, A. Kossenkov, Laxminarasimha Donthireddy, To Tsun Ki Jerrick, Z. Schug, Subhasree Basu, F. Wang, E. Ricciotti, C. DiRusso, M. Murphy, R. Vonderheide, P. Lieberman, Charles Mulligan, Brian Nam, N. Hockstein, G. Masters, M. Guarino, Cindy Lin, Yulia Nefedova, P. Black, V. Kagan, D. Gabrilovich   +24 more
semanticscholar   +1 more source

An Attempt to Polarize Human Neutrophils Toward N1 and N2 Phenotypes in vitro

Frontiers in Immunology, 2020
Neutrophils act as the first line of defense against invading pathogens. Although traditionally considered in context of their antimicrobial effector functions, the importance of tumor-associated neutrophils (TANs) in the development of cancer has become
Mareike Ohms, Sonja Möller, T. Laskay
semanticscholar   +1 more source

Durable and controlled depletion of neutrophils in mice

Nature Communications, 2020
Neutrophils are an essential part of the innate immune system. To study their importance, experimental studies often aim to deplete these cells, generally by injecting anti-Ly6G or anti-Gr1 antibodies.
G. Boivin, julien Faget, P. Ancey, A. Gkasti, J. Mussard, Camilla Engblom, C. Pfirschke, Caroline Contat, J. Pascual, J. Vazquez, N. Bendriss-Vermare, C. Caux, M. Vozenin, M. Pittet, M. Gunzer, E. Meylan   +15 more
semanticscholar   +1 more source

Neutrophils and Malaria

Frontiers in Immunology, 2018
Neutrophils are abundant in the circulation and are one of the immune system's first lines of defense against infection. There has been substantial work carried out investigating the role of neutrophils in malaria and it is clear that during infection ...
Elizabeth H. Aitken, Agersew Alemu, Stephen J. Rogerson   +2 more
doaj   +1 more source