Results 41 to 50 of about 534,504 (310)

Neutrophil antimicrobial defense against Staphylococcus aureus. contribution of cathelicidin and the NADPH oxidase [PDF]

, 2009
Neutrophils are among the most important components of the innate immune response, which provides the first line of host defense. The antimicrobial potential of neutrophils has been traditionally divided into either non-oxidative or oxidative ...
Jann, Naja
core   +1 more source

Functional activities of C-reactive protein on neutrophils [PDF]

C-reactive protein (CRP) is a member of the pentraxin family which opsonises S. pneumoniae through its binding to phosphorylcholine. In addition, CRP binds to Fcγ receptors: FcγRI with high affinity and, probably, FcγRIIA with lower affinity.
Rodriguez, Jairo Antonio
core   +1 more source

Human CD79b+ neutrophils in the blood are associated with early-stage melanoma

Frontiers in Immunology, 2023
PurposeDue to their abundance in the blood, low RNA content, and short lifespan, neutrophils have been classically considered to be one homogenous pool.
Melissa A. Meyer, Huy Q. Dinh, Huy Q. Dinh, Ahmad Alimadadi, Daniel J. Araujo, Nandini Chatterjee, Norma A. Gutierrez, Yanfang Peipei Zhu, Yanfang Peipei Zhu, Yanfang Peipei Zhu, Emma L. Hunter, Shu Liang, Gregory Seumois, William B. Kiosses, Sergio D. Catz, Pandurangan Vijayanand, Christian Ottensmeier, Christian Ottensmeier, Christian Ottensmeier, Catherine C. Hedrick, Catherine C. Hedrick   +20 more
doaj   +1 more source

Ccl2 and Ccl3 Mediate Neutrophil Recruitment via Induction of Protein Synthesis and Generation of Lipid Mediators [PDF]

, 2009
Objective: Although the chemokines monocyte chemoattractant protein-1 (Ccl2/JE/MCP-1) and macrophage inflammatory protein-1α (Ccl3/MIP-1α) have recently been implicated in neutrophil migration, the underlying mechanisms remain largely unclear.
Alexander Georg Khandoga, Nina Berberich, Peter Bihari, Stefan Zahler, Rehberg, Markus, Fritz Krombach, Krombach, Fritz, Max Lerchenberger, Lerchenberger, Max, Berberich, Nina, Reichel, Christoph A., Christoph Andreas Reichel, Markus Rehberg, Bihari, Peter, Zahler, Stefan, Khandoga, Alexander G.   +15 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Alkalinity of Neutrophil Phagocytic Vacuoles Is Modulated by HVCN1 and Has Consequences for Myeloperoxidase Activity.

, 2015
The NADPH oxidase of neutrophils, essential for innate immunity, passes electrons across the phagocytic membrane to form superoxide in the phagocytic vacuole.
Adam P Levine, Michael R Duchen, Peter R. Rich, Anthony W. Segal, Adam P. Levine, de Villiers, S, Anthony W Segal, Simon de Villiers (725764), Peter R. Rich (725765), Michael R. Duchen (49273), Peter R Rich, Levine, AP, Duchen, MR, Simon de Villiers, Michael R. Duchen, Rich, PR, Adam P. Levine (473969), Anthony W. Segal (251124), Segal, AW   +18 more
core   +1 more source

Cancer-associated fibroblasts promote pro-tumor functions of neutrophils in pancreatic cancer via IL-8: potential suppression by pirfenidone

Cancer Immunology, Immunotherapy
Background The mechanisms by which neutrophils acquire pro-tumor properties remain poorly understood. In pancreatic cancer, cancer-associated fibroblasts (CAFs) may interact with neutrophils, directing them to promote tumor progression.
Tomohiko Yagi, Shunsuke Kagawa, Shohei Nogi, Atsuki Taniguchi, Masashi Yoshimoto, Kanto Suemori, Yasuo Nagai, Shuto Fujita, Shinji Kuroda, Satoru Kikuchi, Yoshihiko Kakiuchi, Fuminori Teraishi, Kosei Takagi, Toshiaki Ohara, Hiroshi Tazawa, Toshiyoshi Fujiwara   +15 more
doaj   +1 more source

Tbp and Hprt1 Are Appropriate Reference Genes for Splenic Neutrophils Isolated from Healthy or Tumor-Bearing Mice

Biomedicines
Background/Objectives: Neutrophils have recently gained significant attention due to their heterogeneity in tumor settings. The gene expression profiles of neutrophils from different tumor types are of great interest.
Khetam Sounbuli, Ludmila A. Alekseeva, Aleksandra V. Sen’kova, Innokenty A. Savin, Marina A. Zenkova, Nadezhda L. Mironova   +5 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Neutrophil and neutrophil extracellular trap involvement in neutrophilic asthma: A review

Medicine
Asthma is a highly prevalent chronic inflammatory disease characterized by variable airflow obstruction and airway hyperresponsiveness. Neutrophilic asthma (NA) is classified as “type 2 low” asthma, defined as 65% or more neutrophils in the total cell count.
Yuemu Li, Tianyi Yang, Baihua Jiang
openaire   +2 more sources