Urokinase-Type Plasminogen Activator Promotes Paracellular Transmigration of Neutrophils Via Mac-1, But Independently of Urokinase-Type Plasminogen Activator Receptor [PDF]
, 2011 Background: Urokinase-type plasminogen activator (uPA) has recently been implicated in the pathogenesis of ischemia-reperfusion (I/R) injury. The underlying mechanisms remain largely unclear.
Paul J. Declerck +27 more
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Neutrophil-mediated injury to endothelial cells. Enhancement by endotoxin and essential role of neutrophil elastase [PDF]
, 1986 The neutrophil has been implicated as an important mediator of vascular injury, especially after endotoxemia. This study examines neutrophil-mediated injury to human microvascular endothelial cells in vitro. We found that neutrophils stimulated by formyl-
M G Tonnesen +15 more
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The regulatory roles of neutrophils in adaptive immunity
Cell Communication and Signaling, 2019 Neutrophils have long been considered as cells playing a crucial role in the immune defence against invading pathogens. Accumulating evidence strongly supported the direct and indirect regulatory effects of neutrophils on adaptive immunity.
Yang Li +5 more
doaj +1 more source
Journal of Immunology Research, 2021 Neutrophils are prominent components of gastric cancer (GC) tumors and exhibit distinct phenotypes in GC environment. However, the phenotype, regulation, and clinical relevance of neutrophils in human GC are presently unknown. Here, immunohistochemistry,
Zhi-guo Shan +8 more
doaj +1 more source
Simvastatin reduces endotoxin-induced acute lung injury by decreasing neutrophil recruitment and radical formation. [PDF]
, 2012 Treatment of acute lung injury (ALI) remains an unsolved problem in intensive care medicine. As simvastatin exerts protective effects in inflammatory diseases we explored its effects on development of ALI and due to the importance of neutrophils in ALI ...
Vijayan, Santosh +49 more
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AHNAK and inflammatory markers predict poor survival in laryngeal carcinoma. [PDF]
, 2012 AHNAK/Desmoyokin is a giant protein which has been recently linked to reorganization of the actin cytoskeleton, cellular migration and invasion. Here, we investigated the role of AHNAK in the pathophysiology of larynx carcinoma-one of the major subtypes ...
Reinhard Zeidler +13 more
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The Role Of Serum Amyloid A In Inflammatory Disease - Proinflammatory Mediator Or Inert Biomarker? [PDF]
, 2010 : Neutrophils are phagocytes of the innate immune system with prominent roles in host defense and are also believed to be important in autoimmune diseases such as rheumatoid arthritis (RA) by accumulating in inflamed joints and contribute to tissues ...
Björkman, Lena
core +1 more source
Olfactomedin 4 marks a subset of neutrophils in mice
Innate Immunity, 2019 Neutrophils are the most abundant immune cell of the innate immune system and participate in essential immune functions. Heterogeneity within neutrophils has been documented, but it is difficult to distinguish if these are altered activation states of a ...
Matthew N Alder +5 more
doaj +1 more source
Mineral trioxide aggregate induces the release of matrix metalloproteinase-9 by human neutrophils
Journal of Dental Sciences, 2013 Background/purpose: As a pulp capping agent, mineral trioxide aggregate (MTA) is commonly applied on inflamed tissues that present with a variety of immunocompetent cells, including neutrophils. Neutrophils are a major source of matrix metalloproteinases
Ya-Yun Lee +5 more
doaj +1 more source
Innate immune response in bovine neutrophils stimulated with Mycoplasma bovis
Veterinary Research, 2021 Mycoplasma bovis (M. bovis) is a significant worldwide pathogen of cattle. Neutrophils have an important role in the innate immune response during infection with M. bovis. However, even though neutrophils accumulate in M. bovis infection, the interaction
Satoshi Gondaira +8 more
doaj +1 more source