Results 11 to 20 of about 18,529 (226)

An enzyme that inactivates the inflammatory mediator leukotriene b4 restricts mycobacterial infection. [PDF]

PLoS ONE, 2013
While tuberculosis susceptibility has historically been ascribed to failed inflammation, it is now known that an excess of leukotriene A4 hydrolase (LTA4H), which catalyzes the final step in leukotriene B4 (LTB4) synthesis, produces a hyperinflammatory ...
David M Tobin, Francisco J Roca, John P Ray, Dennis C Ko, Lalita Ramakrishnan   +4 more
doaj   +2 more sources

Functional Properties and Molecular Architecture of Leukotriene A4 Hydrolase, a Pivotal Catalyst of Chemotactic Leukotriene Formation [PDF]

The Scientific World Journal, 2002
The leukotrienes are a family of lipid mediators involved in inflammation and allergy. Leukotriene B4 is a classical chemoattractant, which triggers adherence and aggregation of leukocytes to the endothelium at only nM concentrations.
Jesper Z. Haeggström, Pär Nordlund, Marjolein M.G.M. Thunnissen   +2 more
doaj   +2 more sources

Suppression of leukotriene B4 production is involved in the anti-pruritic action of Grifola frondosa in pollen allergy-induced ocular itching in mice

Food and Agricultural Immunology, 2021
Grifola frondosa (G. frondosa) is an edible mushroom consumed as a health food in Asia that has recently been reported to have anti-allergic effects. In this study, we investigated the effects of G.
Junya Kawai, Tsugunobu Andoh, Koichiro Mori   +2 more
doaj   +2 more sources

Circulating Leukotriene B4 Identifies Respiratory Complications after Trauma [PDF]

Mediators of Inflammation, 2012
Background. Leukotriene B4 (LTB4), a proinflammatory lipid mediator correlates well with the acute phase of Acute Respiratory Distress Syndrome (ARDS). Therefore, LTB4-levels were investigated to determine whether they might be a useful clinical marker ...
Birgit Auner, Emanuel V. Geiger, Dirk Henrich, Mark Lehnert, Ingo Marzi, Borna Relja   +5 more
doaj   +2 more sources

Effect of montelukast on leukotriene B4 metabolism in asthma [PDF]

Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023
Objective·To observe the effect of montelukast on the expressions of key genes in LTB4 (leukotriene B4) metabolic pathway in treating asthma and investigate the candidate intervene targets of asthma.Methods·The acute, subacute, and chronic asthmatic ...
HU Yu, XIE Liang, ZOU Dan, FU Hongling, LOU Lili, XIE Keqi, LIU Hanmin   +6 more
doaj   +2 more sources

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

The leukotriene B₄/BLT₁ axis is a key determinant in susceptibility and resistance to histoplasmosis. [PDF]

PLoS ONE, 2014
The bioactive lipid mediator leukotriene B4 (LTB4) greatly enhances phagocyte antimicrobial functions against a myriad of pathogens. In murine histoplasmosis, inhibition of the LT-generating enzyme 5-lypoxigenase (5-LO) increases the susceptibility of ...
Adriana Secatto, Elyara Maria Soares, Gisele Aparecida Locachevic, Patricia Aparecida Assis, Francisco Wanderlei Garcia Paula-Silva, Carlos Henrique Serezani, Alexandra Ivo de Medeiros, Lúcia Helena Faccioli   +7 more
doaj   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Effect of montelukast on platelet activating factor- and tachykinin induced mucus secretion in the rat [PDF]

, 2008
Background: Platelet activating factor and tachykinins (substance P, neurokinin A, neurokinin B) are important mediators contributing to increased airway secretion in the context of different types of respiratory diseases including acute and chronic ...
David A Groneberg, Groneberg, David A., Wagner, Ulrich, Groneberg, Jan David Alexander, Groneberg David A, Staats Petra, Schmidt Rene, Ulrich Wagner, Schmidt, Rene, Petra Staats, Staats, Petra, Rene Schmidt, Wagner Ulrich   +12 more
core   +1 more source

The leukotriene B4 receptors BLT1 and BLT2 form an antagonistic sensitizing system in peripheral sensory neurons

, 2022
S.6123-6134Sensitization of the heat-activated ion channel transient receptor potential vanilloid 1 (TRPV1) through lipids is a fundamental mechanism during inflammation-induced peripheral sensitization. Leukotriene B4 is a proinflammatory lipid mediator
Treutlein, E.M., Pierre, S., Scholich, K., Tunaru, S., Ferreiros, N., Geisslinger, G., Offermanns, S., Zinn, S., Leffler, A., DeBruin, N., Angioni, C., Kern, K., Suo, J., Jordan, H., Sisignano, M.   +14 more
core   +1 more source