Results 21 to 30 of about 18,529 (226)

Fish Oil in the Treatment of Ulcerative Colitis

Canadian Journal of Gastroenterology, 1990
Patients with active ulcerative colitis have increased levels of leukotriene B4 in their rectal mucosa. Eicosapentaenoic acid (EPA) competitively inhibits the cyclo-oxgenase pathway and reduces the formation of cyclo-oxygenase pathway products.
C Ó'Moráin, A Tobin, T McColl, Y Suzuki   +3 more
doaj   +1 more source

COMPARISON OF SELECTIVE AND NON SELECTIVE CYCLO-OXYGENASE 2 INHIBITORS IN EXPERIMENTAL COLITIS EXACERBATION: role of leukotriene B4 and superoxide dismutase

Arquivos de Gastroenterologia, 2014
Context Nonsteroidal anti-inflammatory drugs are considered one of the most important causes of reactivation of inflammatory bowel disease. With regard to selective cyclo-oxygenase 2 inhibitors, the results are controversial in experimental colitis as ...
José Wander BREGANÓ, Décio Sabbatini BARBOSA, Mirian Zebian El KADRI, Maria Aparecida RODRIGUES, Rubens CECCHINI, Isaias DICHI   +5 more
doaj   +1 more source

Design of benzimidazoles, benzoxazoles, benzothiazoles and thiazolopyridines as leukotriene A4 hydrolase inhibitors through 3D-QSAR, docking and molecular dynamics [PDF]

Journal of the Serbian Chemical Society, 2023
Human leukotriene A4 hydrolase enzyme (LTA4H) catalyses the biotransformation of the inactive precursor leukotriene A4 (LTA4) to the bioactive Leukotriene B4 (LTB4), which causes many inflammatory responses in the human body.
Lorca Marcos, Faúndez Mario, Pessoa-Mahana David C., Recabarren-Gajardo Gonzalo, Diethelm-Varela Benjamin, Millán Daniela, Celik Ismail, Mellado Marco, Araque Ileana, Mella Jaime, Romero-Parra Javier   +10 more
doaj   +1 more source

Is leukotriene B4 one of the keloid marker? a fibroblast keloid study

Dermatology Reports, 2019
Keloid pathogenesis occurs due to the duration of prolonged inflammatory phase and increased production of various growth factors such as TGF-β1 which may cause increasing fibroblast proliferation and collagen synthesis.
Yuli Kurniawati, Oki Suwarsa, A. Achadiyani, Sudigdo Adi   +3 more
doaj   +1 more source

A rare case of Sjogren-Larsson syndrome with recurrent pneumonia and asthma [PDF]

Korean Journal of Pediatrics, 2016
Sjogren-Larsson syndrome (SLS) is a rare autosomal recessive neurocutaneous disorder with worldwide incidence of 0.4 per 100,000 people. It is characterized by the triad of congenital ichthyosis, spastic diplegia or quadriplegia, and mental retardation ...
Azita Tavasoli, Shirin Sayyahfar, Babak Behnam   +2 more
doaj   +1 more source

The IRE1α Inhibitor KIRA6 Blocks Leukotriene Biosynthesis in Human Phagocytes

Frontiers in Pharmacology, 2022
The ER stress and Unfolded Protein Response (UPR) component inositol-requiring enzyme 1α (IRE1α) has been linked to inflammation and lipid mediator production.
Xiao Tang, Tarvi Teder, Bengt Samuelsson, Jesper Z. Haeggström   +3 more
doaj   +1 more source

Effects of perioperative supplementation with omega-3 fatty acids on leukotriene B4 and leukotriene B5 production by stimulated neutrophils in patients with colorectal cancer: a randomized, placebo-controlled intervention trial

, 2014
Omega-3 fatty acids (n-3 FA) may have beneficial clinical and immune-modulating effects in surgical patients. In a randomized, double-blind, prospective, placebo-controlled trial, 148 patients referred for elective colorectal cancer surgery received an n-
Schmidt, E.B., Schmidt, Lone, Thorlacius-Ussing, Ole; id_orcid, Thorlacius-Ussing, O., Erik Schmidt, Ole Thorlacius-Ussing, Rasmussen, Henrik Højgaard, Lundbye-Christensen, S., Lindhorff-Larsen, K., Lindorff Larsen, Karen, Sorensen, L.S., Calder, P.C., Henrik Rasmussen, Søren Lundbye-Christensen, Rasmussen, H.H., Lundbye-Christensen, Søren; id_orcid, Lone Sorensen, Philip. Calder, Calder, Philip C, Schmidt, Erik Berg, Karen Lindorff-Larsen   +20 more
core   +1 more source

Leukotriene B4 Formation During Human Neutrophil Keratinocyte Interactions: Evidence for Transformation of Leukotriene A4 by Putative Keratinocyte Leukotriene A4 Hydrolase

, 1993
In the present study, keratinocytes were coincubated with human neutrophils to determine whether or not an increase in leukotriene B4 formation can occur.
Iversen, Lars, Schmedes, Anne, Kragballe, Knud, Ziboh, Vincent A., Fogh, Karsten, Kristensen, Peter   +5 more
core   +1 more source

Possible Involvement of 5-Lipoxygenase Metabolite in Itch-Associated Response of Mosquito Allergy in Mice

Journal of Pharmacological Sciences, 2007
This study investigated endogenous mediators involved in mosquito allergy-associated itching in mice. An intradermal injection of an extract of mosquito salivary gland elicited marked scratching in sensitized mice.
Yasushi Kuraishi, Eiji Ohtsuka, Tasuku Nakano, Sanae Kawai, Tsugunobu Andoh, Hiroshi Nojima, Kiyoshi Kamimura   +6 more
doaj   +1 more source

Validity of serum leukotriene B4 as a marker of decompensated liver cirrhosis in chronic HCV patients: leukotriene B4 in decompensated liver cirrhosis

Egyptian Liver Journal, 2021
Background Liver cirrhosis is divided into two stages: compensated stage and another advanced stage which includes both decompensated cirrhosis and acute-on-chronic liver failure.
Ayman El-Shayeb, Sawsan El-Mallah, Akram Deghady, Samar El-Hewely, Doaa Elwazzan   +4 more
doaj   +1 more source